Results 241 to 250 of about 1,427,308 (312)

A Prospective Study of Individuals at Risk of Multiple Sclerosis Informs the Design of Primary Prevention Studies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective In multiple sclerosis, the optimal time for deploying a therapeutic intervention is before the central nervous system is damaged; given the success of trials treating the earliest stage of MS, the radiologically isolated syndrome, developing primary prevention strategies is an important next challenge.
Amy W. Laitinen, Ceren Tozlu, Tina Roostaei, Fatoumata Diallo, Kaho Onomichi, Jiyeon Son, Zongqi Xia, Philip L. De Jager   +7 more
wiley   +1 more source

A Retrospective Analysis of Soft Tissue Point-of-Care Ultrasound (POCUS) in Primary Care. [PDF]

J Am Board Fam Med
Killeen D, Shofer F, Panebianco N, Baraniecki-Zwil G, Kramer J.   +4 more
europepmc   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Evidence of Iron Accumulation in Cerebral Adrenoleukodystrophy: A Potential Novel Disease Mechanism

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT In this first application of Quantitative Susceptibility Mapping Source Separation to cerebral adrenoleukodystrophy, we uncovered alterations in iron and myelin within lesions and normal appearing white matter. As validation, we demonstrate abnormal iron accumulation in those same compartments within primary brain tissue.
Christina L. Nemeth, Mert Sisman, Jinwei Zhang, Hyeong‐geol Shin, Xu Li, Bela Turk, Ali Fatemi, Thanh Nguyen, Eric Mallack   +8 more
wiley   +1 more source

Clinical application of the REVEAL™ fluorescence loupe in oral lesion assessment: a five-case clinical note. [PDF]

Lasers Med Sci
Albino Souza M, Copatti Dogenski L, Chitolina G, Lunelli Ferrari E, Rovani G, Steier L, Poli de Figueiredo JA, De Carli JP.   +7 more
europepmc   +1 more source

Overcoming Diagnostic and Therapeutic Challenges in Primary Cardiac Angiosarcoma. [PDF]

JACC Case Rep
Pons-Riverola A, Napolitano A, Rosendahl U, Lyon AR, Nazir MS.   +4 more
europepmc   +1 more source

A rapid pathological diagnosis based on unfixed frozen tissue section leads to the misdiagnosis of eosinophilic myocarditis as lymphocytic myocarditis

Saya Hirata, Kenichiro Suwa, Atsushi Sakamoto, Hayato Ohtani, Takashi Tsuchida, Yuichiro Maekawa   +5 more
openalex   +2 more sources

Double Torsion of a Continuous Type of a Splenogonadal Fusion Presenting as an Inguinoscrotal Emergency: A Rare Case Report. [PDF]

Int Med Case Rep J
Ahmad O, Shbani A, Ranjous Y, Alkhabbaz O, Khabbaz AAM.   +4 more
europepmc   +1 more source

Targeted and immunotherapy based on tissue of origin in carcinoma of unknown primary: a two-case report and literature review. [PDF]

Front Oncol
Wang M, Yan D, Sun W, Liang J.
europepmc   +1 more source