Results 131 to 140 of about 8,279,566 (317)

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Tissue distribution and excretion kinetics of orally administered silica nanoparticles in rats

, 2014
Jeong-A Lee,1 Mi-Kyung Kim,1 Hee-Jeong Paek,1 Yu-Ri Kim,2 Meyoung-Kon Kim,2 Jong-Kwon Lee,3 Jayoung Jeong,3 Soo-Jin Choi1 1Department of Food Science and Technology, Seoul Women’s University, Seoul, Republic of Korea; 2Department of Biochemistry ...
Jeong J, Paek HJ, Lee JA, Lee JK, Kim MK, Choi SJ, Kim YR   +6 more
core  

Interstitial fluid pressure distribution in tumour and normal tissue.

, 2017
Interstitial fluid pressure distribution in tumour and normal tissue.
Xiao Yun Xu (3756703), Wenbo Zhan (2158123), Wladyslaw Gedroyc (1607500)   +2 more
core   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Pharmacokinetic, Tissue Distribution, Metabolite, and Toxicity Evaluation of the Matrine Derivative, (6aS, 10S, 11aR, 11bR, 11cS)-10-Methylaminododecahydro-3a, 7a-Diaza-benzo (de) Anthracene-8-thione

Molecules
MASM, a structurally modified derivative of matrine, exhibits superior efficacy in reducing inflammation and liver injury in rats when compared to matrine.
Liuyan Li, Fangfang Lu, Shuqin Ding, Xiaoying Wang, Weibiao Wang, Wannian Zhang, Weiheng Xu, Chunlin Zhuang, Zhenyuan Miao, Xueqin Ma   +9 more
doaj   +1 more source

Pharmacokinetic parameters and tissue distribution of magnetic Fe3O4 nanoparticles in mice

, 2010
Jun Wang1, Yue Chen1, Baoan Chen1, Jiahua Ding1, Guohua Xia1, Chong Gao1, Jian Cheng1, Nan Jin1, Ying Zhou1, Xiaomao Li1, Meng Tang2, Xue Mei Wang21Department of Hematology, Zhongda Hospital, Clinical Medical School, Southeast University, Nanjing, People&
Jun Wang, Baoan Chen, et al, Yue Chen
core  

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Fluorescent α-Conotoxin [Q1G, ΔR14]LvIB Identifies the Distribution of α7 Nicotinic Acetylcholine Receptor in the Rat Brain

Marine Drugs
α7 nicotinic acetylcholine receptors (nAChRs) are mainly distributed in the central nervous system (CNS), including the hippocampus, striatum, and cortex of the brain. The α7 nAChR has high Ca2+ permeability and can be quickly activated and desensitized,
Hongyu Shan, Nan Wang, Xinyu Gao, Zihan Wang, Jinpeng Yu, Dongting Zhangsun, Xiaopeng Zhu, Sulan Luo   +7 more
doaj   +1 more source

BCTB FFPE (Formalin Fixed Paraffin Embedded) Blocks

This BCTB tissue subcollection consists of FFPE (Formalin Fixed Paraffin Embedded) blocks: pieces of tissue fixed in formalin, dehydrated and embedded into wax, then thinly sliced for viewing under a microscope.

core  

Study of pharmacokinetics and tissue distribution of liposomal brucine for dermal administration

, 2011
Bai-Can Yang1, Zhi-Feng Chu1, Sha Zhu1, Li-Jun Wang1, Yu-Hong Feng1, Feng-Hua Li1, Chang-Sheng Liu2, Yuan Yuan21Pharmacy Department of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, People’s ...
Feng Y-H, Liu C-S, Chu Z-F, Li F-H, Yang B-C, Wang L-J, Zhu S, Yuan Y   +7 more
core