Results 141 to 150 of about 8,279,566 (317)
Molecular Oncology, EarlyView.High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source
Frontiers in PharmacologyIntroduction:Ginsenoside Rh3 (GRh3), a rare ginsenoside, demonstrates diverse pharmacological activities in vitro; however, the lack of pharmacokinetic and tissue distribution data has limited its translation to in vivo applications.
Cong Hu +8 more
doaj +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Investigation of the relationship between iron and high field MRI in healthy and Alzheimer's disease tissue [PDF]
It has been proposed that increased tissue iron concentration, which has been observed in certain regions of the brain in individuals with Alzheimer’s Disease (AD), could provide a marker for diagnosis through detection with MRI.
Finnegan, Mary E.
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Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
A novel tetrandrine-loaded chitosan microsphere: characterization and in vivo evaluation
Drug Design, Development and Therapy, 2016 Kefang Guo, Jing Cang Department of Anesthesia, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of China Abstract: In this study, novel tetrandrine-loaded chitosan microspheres were prepared by the emulsion cross-linking method.
Guo KF, Cang J
doaj
BCTB Non-Invasive Breast Cancer Samples and Images
This BCTB subcollection contains breast tissue and blood samples, and associated images, where a diagnosis of non-invasive cancer has been determined by a ...
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An Essay on the Philosophy and Psychodynamics of Income Distribution
, 1992 This essay considers certain fundamental aspects of the philosophy and psychodynamics of distribution and how they have entered economic theory. It treats, first, considerations of distribution as a driving force in the economy; second, the forces and ...
Samuels, W. J.
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Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source