Results 141 to 150 of about 12,729,869 (376)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Non‐Rayleigh Statistics of Ultrasonic Backscattered Echo from Tissues [PDF]

, 1994
The envelope of the backscattered signal from tissues can exhibit non‐Rayleigh statistics if the number density of scatterers is small or if the variations in the scattering cross sections are random. The K distribution which has been used extensively in
Molthen, Robert C., Narayanan, V. Manjo, Reid, J. M., Shankar, P. M.   +3 more
core   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

A general mathematical framework for understanding the behavior of heterogeneous stem cell regeneration

, 2019
Stem cell heterogeneity is essential for the homeostasis in tissue development. This paper established a general formulation for understanding the dynamics of stem cell regeneration with cell heterogeneity and random transitions of epigenetic states. The
Lei, Jinzhi
core   +1 more source

Immunohistochemical Localization of Hepatocyte Growth Factor Activator (HGFA) in Developing Mouse Liver Tissues: Heterogeneous Distribution of HGFA Protein [PDF]

, 2003
Ichiei Iida, Kohei Johkura, Ruifeng Teng, Suguru Kubota, Li Cui, Xu Zhao, Naoko Ogiwara, Yasumitsu Okouchi, Kazuhiko Asanuma, Jun Nakayama, Katsunori Sasaki   +10 more
openalex   +1 more source

Zinc distribution within breast cancer tissue of different intrinsic subtypes [PDF]

, 2020
P Rüsch, Alfred V. Hirner, Oliver J. Schmitz, Rainer Kimmig, Oliver Hoffmann, Maxim Diel   +5 more
openalex   +1 more source

Tissue Distribution of 5-Hydroxymethylcytosine and Search for Active Demethylation Intermediates

PLoS ONE, 2010
5–Hydroxymethylcytosine (hmC) was recently detected as the sixth base in mammalian tissue at so far controversial levels. The function of the modified base is currently unknown, but it is certain that the base is generated from 5-methylcytosine (mC ...
D. Globisch, M. Münzel, Markus Müller, S. Michalakis, Mirko Wagner, Susanne F. Koch, Tobias Brückl, M. Biel, T. Carell   +8 more
semanticscholar   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Research and development program for radiation measurements of radiobiological hazards of man in space Summary technical report, 1 Aug. 1965 - 31 Jul. 1966 [PDF]

Macroscopic and microscopic distribution of dose deposited in tissue by high energy protons - spherical proportional counters and silicon Au-i-Al ...

core   +1 more source