Results 191 to 200 of about 8,279,566 (317)

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Effects of borneol on pharmacokinetics and tissue distribution of tetramethylpyrazine in transdermal patch. [PDF]

Drug Deliv Transl Res
Cui L, Zha L, Mei J, Xue R, Wang J, Zhang Z, Ma Y.   +6 more
europepmc   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Favipiravir tissue distribution and inhibitory quotients in preclinical models: towards a pipeline for evidence-based antiviral repurposing. [PDF]

J Antimicrob Chemother
Petit PR, Touret F, Driouich JS, Paré A, de Lamballerie X, Marlin R, Contreras V, Relouzat F, Gallouët AS, Pascal Q, Guedj J, Le Grand R, Nougairède A, Solas C.   +13 more
europepmc   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Methylglyoxal as a Convergent Mediator of Diabetic Complications: Generation, Protein Targets, Tissue Distribution, and Therapeutic Reduction-A Clinically Oriented Mechanistic Synthesis. [PDF]

Biomolecules
Fernandez EC.
europepmc   +1 more source

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source

Clinical Course, Laboratory Findings, and Tissue Distribution of Highly Pathogenic Avian Influenza A(H5N1) Virus in a Naturally Infected Domestic Cat. [PDF]

Viruses
Augustyniak A, Czyżewska-Dors E, Łagowski D, Domańska-Blicharz K, Lisowska A, Opolska J, Gogulski M, Pomorska-Mól M.   +7 more
europepmc   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Influences of formulations and administration routes on docetaxel tissue distribution in mice. [PDF]

Sci Rep
Dong X, Zhang T, Shah B, Bae SH, Mans JC.   +4 more
europepmc   +1 more source