Results 211 to 220 of about 8,279,566 (317)

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Novel Poly(amidoamine)-Based Hydrogels as Scaffolds for Tissue Engineering

, 2005
F. Chiellini, P. Ferruti, S. Bianchi, E. Ranucci, V. Caruso   +4 more
core   +1 more source

The Effect of Serum Carnosinase on the Tissue Distribution of Imidazole Dipeptides After Their Oral Administration in Golden Hamsters. [PDF]

Nutrients
Shiotani S, Kawashima T, Takahashi C, Sakano T, Kuramoto A, Yanai N.   +5 more
europepmc   +1 more source

Fluorination: A strategy to tune the interactions of molecules and nanoscale systems with biological matter

FEBS Open Bio, EarlyView.
This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli, Beatrice Lucia Bona, Francesca Baldelli Bombelli   +2 more
wiley   +1 more source

Tissue distribution of Histoplasma capsulatum in deceased people living with HIV assessed by minimally invasive tissue sampling: An autopsy-based case series in the Brazilian Amazon. [PDF]

PLoS Negl Trop Dis
Solórzano-Chavarría KJ, Graciliano TS, Lacerda IPS, Silva-Neto AV, Ferreira L, Santana MF, Cruz KS, Silva Santos CS, Almeida JDR, Oliveira LA, Ordi J, Rakislova N, Martinez M, Hurtado JC, Souza JVB, Bassat Q, Guimarães Lacerda MV, Baía-da-Silva DC.   +17 more
europepmc   +1 more source

A nationwide student survey on biochemistry learning resources in Italy

FEBS Open Bio, EarlyView.
We conducted a survey among Italian university students to investigate their preferred study materials for biochemistry. We then analyzed the collected data to identify these materials. This information may be valuable to the Biochemistry educational community. The graphical abstract was created with Claude (Opus 5.5; Anthropic, 2026).
Anna Marabotti, Ivano Eberini, Maria Luisa Genova, Francesca Mensitieri, Francesco Malatesta   +4 more
wiley   +1 more source

Leveraging [¹⁸F]F-Piflufolastat PET for PBPK Prediction of Tissue Distribution and Therapy Optimization in Prostate Cancer. [PDF]

Clin Transl Sci
van der Gaag S, Veerman MJC, Yilmaz H, Amsu J, Pruijn SJV, Oprea-Lager DE, Cysouw MCF, Jansen BHE, Yaqub MM, Vis AN, Hendrikse H, Bartelink IH.   +11 more
europepmc   +1 more source

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

Tissue distribution and net maintenance and growth requirements of key trace minerals in fattening yaks (<i>Bos grunniens</i>) on the Qinghai-Tibetan plateau. [PDF]

Front Vet Sci
Xu S, Bao S, Zhang J, Wang Z, Liu S, Wang S, Chai S, Wang X, Yang Y, Lv J.   +9 more
europepmc   +1 more source

Hydrogel platforms for 3D cardiac tissue engineering and fibrotic disease modelling

FEBS Open Bio, EarlyView.
Hydrogel‐based cardiac tissue models are advancing our understanding of heart health and disease. By incorporating electrical conductivity, aligned structures, and tunable mechanical properties, these platforms better replicate the complex environment of native heart tissue.
Harrison Porritt, Annika Winbo, Jenny Malmström   +2 more
wiley   +1 more source