Results 231 to 240 of about 1,768,264 (269)

Tissue distribution of exaprolol in rat

European Journal of Drug Metabolism and Pharmacokinetics, 1985
The disposition of the beta adrenoceptor blocking drug 1-(2-cyclohexylphenoxy)-3-isopropylamino-2-propanol, exaprolol, in organs of the rat has been studied. After i.v. administration of 3H-exaprolol a transient extremely high accumulation of the drug in lungs was observed with a peak of 7.7% of dose/g 30 min post-administration.
V, Faberová, T, Trnovec, M, Zemánek, S, Bezek, M, Durisová, O, Tomcíková   +5 more
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DISTRIBUTION AND TURNOVER OF OCTOPAMINE IN TISSUES

Journal of Neurochemistry, 1972
Abstract— Octopamine is a normally occurring amine in several species of animals. Particularly high concentrations are found in the crustacean central nerve cord. In the rat it is specifically localized to sympathetic nerve endings, has a subcellular distribution similar to that of norepinephrine, and is asymmetrically distributed in the CNS.
P B, Molinoff, J, Axelrod
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Tissue distribution of terbinafine in rats

Journal of Pharmaceutical Sciences, 2001
Terbinafine is an allylamine antifungal agent that is highly lipophilic and keratophilic. The aim of this study was to investigate terbinafine distribution in peripheral and visceral tissues after intravenous administration to rats. Terbinafine, 6 mg/kg, was administered to 33 male Sprague-Dawley rats via a jugular vein cannula over 30 s.
M, Hosseini-Yeganeh, A J, McLachlan
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Tissue distribution of transdermal toremifene

Cancer Chemotherapy and Pharmacology, 1997
Toremifene is an orally administered triphenylethylene derivative with antiestrogenic activity that is primarily used in the treatment of patients with metastatic breast cancer. The purpose of this study was to evaluate the therapeutic advantage of local (transdermal) administration of toremifene in several animal models.
L, Soe, G T, Wurz, J U, Mäenpää, G B, Hubbard, T B, Cadman, V J, Wiebe, A P, Theon, M W, DeGregorio   +7 more
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Distribution of Collagenase in Rat Tissues

Nature, 1965
THE demonstration, recently reported from this laboratory1–3, of a collagenolytic system in rat bone-cell homogenates raised several questions regarding its importance in the physiology and pathology of connective tissues4. Since the activity was largely confined to a subcellular particulate fraction exhibiting a number of the features of lysosomes2,3,
J F, Woods, G, Nichols
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Phencyclidine: Tissue Distribution in the Rat

Clinical Toxicology, 1976
This study was performed to provide knowledge of the tissue distribution of phencyclidine and has demonstrated the lipophilic nature of the drug. The distribution of phencyclidine in blood, brain, and adipose tissue of rats has been determined at various time intervals during a 48-hr period.
S H, James, S H, Schnoll
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Distribution of ceftazidime in rat tissues

Biopharmaceutics & Drug Disposition, 1998
The pharmacokinetics and tissue distribution of ceftazidime (CFT), a third generation cephalosporin antibiotic commonly used in clinical practice, were investigated in rats after intravenous administration of the antibiotic. Studies using intravenous bolus administration were carried out at two dose levels (5 and 20 mg) of the antibiotic.
L, Granero, J, Chesa-Jiménez, F, Torres-Molina, J E, Peris   +3 more
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Tissue distribution of the P2X7 receptor

Neuropharmacology, 1997
The P2X7 receptor is a bifunctional molecule. The binding of ATP induces within milliseconds the opening of a channel selective for small cations, and within seconds a larger pore opens which allows permeation by molecules as large as propidium dyes (629 Da).
COLLO, Luigia Rinalda, NEIDHART S, KAWASHIMA E, KOSCO VILBOIS M, NORTH RA, BUELL G.   +5 more
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Distribution of Cimetidine in Postmortem Tissues

Journal of Forensic Sciences, 1984
Abstract The postabsorptive distribution of cimetidine is described. Assays by high pressure liquid chromatography (HPLC) of postmortem samples of cerebrospinal fluid, serum, and solid tissues were used to determine pharmacokinetic parameters as well as mean tissue: serum concentration (T:S) ratios in seven patients with renal and liver ...
M J, Berg, R K, Lantz, J J, Schentag, B A, Vern   +3 more
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Tissue distribution of dextromoramide in the rat

Fundamental & Clinical Pharmacology, 1990
Summary— The tissue distribution of dextromoramide was studied in rats after the intraperitoneal injection of 0.2 mg/kg of the drug. The pattern of distribution was similar at 15, 30, 60 and 90 min, with the highest concentrations being found in the liver and the myocardium, while other organs were not able to concentrate dextromoramide.
P, Kintz, A, Tracqui, P, Mangin, A A, Lugnier, A J, Chaumont   +4 more
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