Results 221 to 230 of about 1,768,264 (269)

Tissue distribution of clenbuterol in the horse

Journal of Veterinary Pharmacology and Therapeutics, 2004
Plasma and tissue concentrations of clenbuterol (CLB) were determined following oral (p.o.) administration of 1.6 μg/kg twice daily (b.i.d.) for 2 weeks. Horses were administered the last dose on morning of day 15, killed at 0.25, 24, 48, and 72 h post‐administration. At 0.25 h, the highest tissue concentrations of CLB were found in the liver (16.21 ng/
L R, Soma, C E, Uboh, F, Guan, Y, Luo, D, Teleis, L, Runbo, E K, Birks, D S, Tsang, P, Habecker   +8 more
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Hexachlorobenzene distribution in tissues of swine

Toxicology and Applied Pharmacology, 1979
Abstract Purified hexachlorobenzene (HCB) was administered to third-litter sows at dietary concentrations of 0, 1, or 20 ppm throughout gestation and nursing. Swine receiving 1 ppm were not adversely affected and residue concentrations in tissues other than fat and bone marrow remained at or below the dietary concentration.
L G, Hansen, J, Simon, S B, Dorn, R H, Teske   +3 more
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Tissue Distribution of Primaquine in the Rat

Pharmacology, 2008
The distribution of primaquine was measured in seven rat tissues at 15–180 min after the intraperitoneal injection of the antimalarial 8-aminoquinoline. The half-life of unmetabolized primaquine was 4.0 h in lung, 1.7–1.9 h in blood, spleen, kidney and heart, and 1.2 h in liver.
D J, Holbrook, J B, Griffin, L, Fowler, B R, Gibson   +3 more
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Pharmacokinetics and tissue distribution of crotonoside

Xenobiotica, 2017
1. Crotonoside is a bioactive ingredient from Croton Herba with a strong antitumour activity. This study aimed to develop a highly sensitive and selective high-performance liquid chromatography (HPLC) method to quantify crotonoside in biological samples for pharmacokinetics and distribution studies. 2.
Peiao, Yan, Lan, Zhang, Cheng, Peng, Ruoqi, Zhang   +3 more
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Tissue distribution of roxithromycin

Journal of Antimicrobial Chemotherapy, 1987
As tissue distribution studies have become increasingly important aspects of the assessment of new antimicrobials, roxithromycin distribution has been evaluated in experimental models and in human tissues and body fluids. High levels were achieved in respiratory tract tissues and fluids and in the male and female genital tract.
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Distribution of sirolimus in rat tissue

Clinical Biochemistry, 1997
To examine the distribution of sirolimus (SRL, rapamycin), an immunosuppressive macrolide antibiotic, in the tissues of adult male Wistar-Furth rats following continuous intravenous infusion (CIVI) and repeated daily peroral gavage (PO).Animals received 14-day courses of SRL by either CIVI (0.04-0.4 mg/kg/day) or PO (0.4-1.6 mg/kg/day) administration ...
K L, Napoli, M E, Wang, S M, Stepkowski, B D, Kahan   +3 more
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The importance of tissue distribution in pharmacokinetics

Journal of Pharmacokinetics and Biopharmaceutics, 1972
In evoking pharmacological and toxicological responses, drugs generally combine either reversibly or irreversibly with action sites on intrastitial macromolecules or organelles, and thereby cause alterations of physico-chemical or biochemical processes in the living animal. These alterations can be evoked by a number of mechanisms.
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Distribution of methotrexate in rat tissues

British Journal of Dermatology, 1974
SUMMARY The distribution of methotrexate between tissues is a very complex process, dependent in part upon the species studied, the size of the dose and the channel of administration. The nature of the tissue and its content of dihydrofolate reductase also play a part. Elimination of methotrexate in the urine and bile indicate that renal and hepatic
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Distribution of Selenium in the Tissues of the Eye

Nature, 1966
FOR the past few years we have been investigating the presence and distribution of selenium in the normal and dystrophic state1,2. The biological role of selenium is as yet unknown; however, the physical and chemical properties of the element are well established.
H H, Taussky, A, Washington, E, Zubillaga, A T, Milhorat   +3 more
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Phenol: Tissue Distribution in a Fatality

Journal of Forensic Sciences, 1989
Abstract A case is reported where phenol, a disinfectant, was ingested and resulted in the death of a 40-year-old white female. Concentrations of phenol were determined in blood (130 mg/L), urine (47 mg/L), bile (187 mg/L), brain (486 mg/kg), kidney (331 mg/kg), muscle (204 mg/kg), liver (228 mg/kg), and stomach content (668 mg) and ...
C, Lo Dico, Y H, Caplan, B, Levine, D F, Smyth, J E, Smialek   +4 more
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