Results 271 to 280 of about 8,279,566 (317)

Distribution of Collagenase in Rat Tissues

Nature, 1965
THE demonstration, recently reported from this laboratory1–3, of a collagenolytic system in rat bone-cell homogenates raised several questions regarding its importance in the physiology and pathology of connective tissues4. Since the activity was largely confined to a subcellular particulate fraction exhibiting a number of the features of lysosomes2,3,
J F, Woods, G, Nichols
openaire   +2 more sources

Tissue distribution of roxithromycin

Journal of Antimicrobial Chemotherapy, 1987
As tissue distribution studies have become increasingly important aspects of the assessment of new antimicrobials, roxithromycin distribution has been evaluated in experimental models and in human tissues and body fluids. High levels were achieved in respiratory tract tissues and fluids and in the male and female genital tract.
openaire   +2 more sources

Phencyclidine: Tissue Distribution in the Rat

Clinical Toxicology, 1976
This study was performed to provide knowledge of the tissue distribution of phencyclidine and has demonstrated the lipophilic nature of the drug. The distribution of phencyclidine in blood, brain, and adipose tissue of rats has been determined at various time intervals during a 48-hr period.
S H, James, S H, Schnoll
openaire   +2 more sources

The importance of tissue distribution in pharmacokinetics

Journal of Pharmacokinetics and Biopharmaceutics, 1972
In evoking pharmacological and toxicological responses, drugs generally combine either reversibly or irreversibly with action sites on intrastitial macromolecules or organelles, and thereby cause alterations of physico-chemical or biochemical processes in the living animal. These alterations can be evoked by a number of mechanisms.
openaire   +1 more source

Distribution of Dextran in the Tissues of Rabbits

Nature, 1952
THE increasing use of dextran solutions as plasma substitutes has made the problem of the fate in the organism of the injected polysaccharide a very important question. Several studies on this problem have been carried out by means of chemical and serological methods of determination of dextran in extracts of tissues1, and a few histological ...
openaire   +2 more sources

Tissue distribution of clenbuterol in the horse

Journal of Veterinary Pharmacology and Therapeutics, 2004
Plasma and tissue concentrations of clenbuterol (CLB) were determined following oral (p.o.) administration of 1.6 μg/kg twice daily (b.i.d.) for 2 weeks. Horses were administered the last dose on morning of day 15, killed at 0.25, 24, 48, and 72 h post‐administration. At 0.25 h, the highest tissue concentrations of CLB were found in the liver (16.21 ng/
L R, Soma, C E, Uboh, F, Guan, Y, Luo, D, Teleis, L, Runbo, E K, Birks, D S, Tsang, P, Habecker   +8 more
openaire   +2 more sources

Hexachlorobenzene distribution in tissues of swine

Toxicology and Applied Pharmacology, 1979
Abstract Purified hexachlorobenzene (HCB) was administered to third-litter sows at dietary concentrations of 0, 1, or 20 ppm throughout gestation and nursing. Swine receiving 1 ppm were not adversely affected and residue concentrations in tissues other than fat and bone marrow remained at or below the dietary concentration.
L G, Hansen, J, Simon, S B, Dorn, R H, Teske   +3 more
openaire   +2 more sources

Pharmacokinetics and tissue distribution of crotonoside

Xenobiotica, 2017
1. Crotonoside is a bioactive ingredient from Croton Herba with a strong antitumour activity. This study aimed to develop a highly sensitive and selective high-performance liquid chromatography (HPLC) method to quantify crotonoside in biological samples for pharmacokinetics and distribution studies. 2.
Peiao, Yan, Lan, Zhang, Cheng, Peng, Ruoqi, Zhang   +3 more
openaire   +2 more sources

Distribution of sirolimus in rat tissue

Clinical Biochemistry, 1997
To examine the distribution of sirolimus (SRL, rapamycin), an immunosuppressive macrolide antibiotic, in the tissues of adult male Wistar-Furth rats following continuous intravenous infusion (CIVI) and repeated daily peroral gavage (PO).Animals received 14-day courses of SRL by either CIVI (0.04-0.4 mg/kg/day) or PO (0.4-1.6 mg/kg/day) administration ...
K L, Napoli, M E, Wang, S M, Stepkowski, B D, Kahan   +3 more
openaire   +2 more sources

Distribution of Selenium in the Tissues of the Eye

Nature, 1966
FOR the past few years we have been investigating the presence and distribution of selenium in the normal and dystrophic state1,2. The biological role of selenium is as yet unknown; however, the physical and chemical properties of the element are well established.
H H, Taussky, A, Washington, E, Zubillaga, A T, Milhorat   +3 more
openaire   +2 more sources