Results 301 to 310 of about 3,009,910 (332)

Tissue distribution of the P2X7 receptor

Neuropharmacology, 1997
The P2X7 receptor is a bifunctional molecule. The binding of ATP induces within milliseconds the opening of a channel selective for small cations, and within seconds a larger pore opens which allows permeation by molecules as large as propidium dyes (629 Da).
COLLO, Luigia Rinalda, NEIDHART S, KAWASHIMA E, KOSCO VILBOIS M, NORTH RA, BUELL G.   +5 more
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Tissue distribution of terbinafine in rats

Journal of Pharmaceutical Sciences, 2001
Terbinafine is an allylamine antifungal agent that is highly lipophilic and keratophilic. The aim of this study was to investigate terbinafine distribution in peripheral and visceral tissues after intravenous administration to rats. Terbinafine, 6 mg/kg, was administered to 33 male Sprague-Dawley rats via a jugular vein cannula over 30 s.
Mahboubeh Hosseini-Yeganeh, Andrew J. McLachlan   +1 more
openaire   +3 more sources

Distribution of ceftazidime in rat tissues

Biopharmaceutics & Drug Disposition, 1998
The pharmacokinetics and tissue distribution of ceftazidime (CFT), a third generation cephalosporin antibiotic commonly used in clinical practice, were investigated in rats after intravenous administration of the antibiotic. Studies using intravenous bolus administration were carried out at two dose levels (5 and 20 mg) of the antibiotic.
F Torres-Molina, José Esteban Peris, Luis Granero, Jesús Chesa-Jiménez   +3 more
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Collagen distribution in tissues [PDF]

, 1984
Collagens are a closely related family of fibrous proteins with similar structure. This family of proteins provides an extracellular framework for all meta-zoan organisms. Besides, collagen also possesses non-structural functions.
Gregório Santiago Montes, Maria S. F. Bezerra, Luiz Carlos Uchôa Junqueira   +2 more
openaire   +1 more source

Tissue distribution of roxithromycin

Journal of Antimicrobial Chemotherapy, 1987
As tissue distribution studies have become increasingly important aspects of the assessment of new antimicrobials, roxithromycin distribution has been evaluated in experimental models and in human tissues and body fluids. High levels were achieved in respiratory tract tissues and fluids and in the male and female genital tract.
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Tissue Distribution of Primaquine in the Rat

Pharmacology, 1981
The distribution of primaquine was measured in seven rat tissues at 15-180 min after the intraperitoneal injection of the antimalarial 8-aminoquinoline. The half-life of unmetabolized primaquine was 4.0 h in lung, 1.7-1.9 h in blood, spleen, kidney and heart, and 1.2 h in liver.
James B. Griffin, David J. Holbrook, Betsy R. Gibson, Linda Fowler   +3 more
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Distribution of hydrocarbons in bovine tissues

Lipids, 1979
AbstractLiver, heart, kidneys, muscle and adipose (perirenal and subcutaneous) tissues were collected from six animals for analysis of their hydrocarbon composition. Qualitative and quantitative determinations were carried out by gas chromatography and combined gas chromatography‐mass spectrometry.
A. Di Muccio, M. P. Bernardini, C. Lintas, A. M. Balduzzi   +3 more
openaire   +3 more sources

Phencyclidine: Tissue Distribution in the Rat

Clinical Toxicology, 1976
This study was performed to provide knowledge of the tissue distribution of phencyclidine and has demonstrated the lipophilic nature of the drug. The distribution of phencyclidine in blood, brain, and adipose tissue of rats has been determined at various time intervals during a 48-hr period.
Stuart H. James, Sidney H. Schnoll
openaire   +3 more sources

Hexachlorobenzene distribution in tissues of swine

Toxicology and Applied Pharmacology, 1979
Abstract Purified hexachlorobenzene (HCB) was administered to third-litter sows at dietary concentrations of 0, 1, or 20 ppm throughout gestation and nursing. Swine receiving 1 ppm were not adversely affected and residue concentrations in tissues other than fat and bone marrow remained at or below the dietary concentration.
Larry G. Hansen, Larry G. Hansen, Richard H. Teske, Richard H. Teske, Joseph Simon, Joseph Simon, Steven B. Dorn, Steven B. Dorn   +7 more
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Tissue distribution of clenbuterol in the horse

Journal of Veterinary Pharmacology and Therapeutics, 2004
Plasma and tissue concentrations of clenbuterol (CLB) were determined following oral (p.o.) administration of 1.6 μg/kg twice daily (b.i.d.) for 2 weeks. Horses were administered the last dose on morning of day 15, killed at 0.25, 24, 48, and 72 h post‐administration. At 0.25 h, the highest tissue concentrations of CLB were found in the liver (16.21 ng/
Yi Luo, Eric K. Birks, P. Habecker, Fuyu Guan, D. Teleis, Deborah Tsang, Lawrence R. Soma, Cornelius E. Uboh, Cornelius E. Uboh, L. Runbo   +9 more
openaire   +3 more sources