Results 311 to 320 of about 3,009,910 (332)

Tissue Distribution of the RAS

1996
The components of the plasma RAS originate primarily from renal renin, hepatic angiotensinogen, and pulmonary converting enzyme (Fig. 1.2). However, recent progress in biotechnological and immunocytochemical techniques enables us to detect trace amounts of biologically active peptides and their mRNA, which facilitates discovery of each component of the
Hideshi Kobayashi, Yoshio Takei
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The importance of tissue distribution in pharmacokinetics

Journal of Pharmacokinetics and Biopharmaceutics, 1972
In evoking pharmacological and toxicological responses, drugs generally combine either reversibly or irreversibly with action sites on intrastitial macromolecules or organelles, and thereby cause alterations of physico-chemical or biochemical processes in the living animal. These alterations can be evoked by a number of mechanisms.
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Tissue Distribution of Connexins

2014
There are more than 20 known connexin proteins identified in the human and mice genome. However, not all the 20 connexins are expressed in all the cells. The expression of connexins has been shown to vary between tissues. Some of the connexins, for example, Cx43, show wide tissue distribution and while others are restricted to a particular cell type or
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Distribution of methotrexate in rat tissues

British Journal of Dermatology, 1974
SUMMARY The distribution of methotrexate between tissues is a very complex process, dependent in part upon the species studied, the size of the dose and the channel of administration. The nature of the tissue and its content of dihydrofolate reductase also play a part. Elimination of methotrexate in the urine and bile indicate that renal and hepatic
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Distribution of Selenium in the Tissues of the Eye

Nature, 1966
FOR the past few years we have been investigating the presence and distribution of selenium in the normal and dystrophic state1,2. The biological role of selenium is as yet unknown; however, the physical and chemical properties of the element are well established.
E. Zubillaga, A. Washington, A. T. Milhorat, H. H. Taussky   +3 more
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Tissue distribution of dextromoramide in the rat

Fundamental & Clinical Pharmacology, 1990
Summary— The tissue distribution of dextromoramide was studied in rats after the intraperitoneal injection of 0.2 mg/kg of the drug. The pattern of distribution was similar at 15, 30, 60 and 90 min, with the highest concentrations being found in the liver and the myocardium, while other organs were not able to concentrate dextromoramide.
Antoine Tracqui, AA Lugnier, P. Mangin, AJ Chaumont, Kintz P   +4 more
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Distribution of Dextran in the Tissues of Rabbits [PDF]

Nature, 1952
THE increasing use of dextran solutions as plasma substitutes has made the problem of the fate in the organism of the injected polysaccharide a very important question. Several studies on this problem have been carried out by means of chemical and serological methods of determination of dextran in extracts of tissues1, and a few histological ...
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DISTRIBUTION AND TURNOVER OF OCTOPAMINE IN TISSUES

Journal of Neurochemistry, 1972
Abstract— Octopamine is a normally occurring amine in several species of animals. Particularly high concentrations are found in the crustacean central nerve cord. In the rat it is specifically localized to sympathetic nerve endings, has a subcellular distribution similar to that of norepinephrine, and is asymmetrically distributed in the CNS.
P. B. Molinoff, Julius Axelrod
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Pressure Distribution in Tissue

2019
This chapter introduces estimates and measurements of the pressure distribution in tissue. Several physical and computer models are included to show the results of estimating tissue pressure distribution. Experimental results suggest causes of pressure sore formation.
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Phenol: Tissue Distribution in a Fatality

Journal of Forensic Sciences, 1989
Abstract A case is reported where phenol, a disinfectant, was ingested and resulted in the death of a 40-year-old white female. Concentrations of phenol were determined in blood (130 mg/L), urine (47 mg/L), bile (187 mg/L), brain (486 mg/kg), kidney (331 mg/kg), muscle (204 mg/kg), liver (228 mg/kg), and stomach content (668 mg) and ...
Barry Levine, John E. Smialek, Dennis F. Smyth, Yale H. Caplan, Charles Lo Dico   +4 more
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