Results 121 to 130 of about 4,783,918 (377)

Methionine formation by transmethylation in vitro [PDF]

, 1947
We reported in a previous communication (1) that guanidoacetic acid is methylated to creatine by rat liver slices in the presence of choline and either homocysteine or homocystine.
Borsook, Henry, Dubnoff, Jacob W.
core  

KRAS and GNAS mutations in cell‐free DNA and in circulating epithelial cells in patients with intraductal papillary mucinous neoplasms—an observational pilot study

Molecular Oncology, EarlyView.
This study demonstrates that KRAS and GNAS mutations are more prevalent in patients with resected intraductal papillary mucinous neoplasms (IPMN) compared to those under clinical surveillance. GNAS mutations significantly differ between the two patient cohorts, indicating that their absence may serve as a potential biomarker to support conservative ...
Christine Nitschke, Marie Tölle, Philipp Walter, Kira Meißner, Mara Goetz, Jolanthe Kropidlowski, Andreas W. Berger, Jakob R. Izbicki, Felix Nickel, Thilo Hackert, Klaus Pantel, Harriet Wikman, Faik G. Uzunoglu   +12 more
wiley   +1 more source

Donor-derived cell-free DNA predicted allograft rejection and severe microvascular inflammation in kidney transplant recipients

Frontiers in Immunology
IntroductionThe aim of this study is to investigate the clinical validity of donor-derived cell-free DNA (dd-cfDNA) in comparison with that of donor specific anti-HLA antibody (DSA) for predicting biopsy-proven rejection (BPR)and severe microvascular ...
Hyung Duk Kim, Hyunjoo Bae, Hyunhye Kang, Hyunhye Kang, Hanbi Lee, Sang Hun Eum, Chul Woo Yang, Yeong Jin Choi, Byung Ha Chung, Eun-Jee Oh, Eun-Jee Oh   +10 more
doaj   +1 more source

Partially blind domain adaptation for age prediction from DNA methylation data [PDF]

arXiv, 2016
Over the last years, huge resources of biological and medical data have become available for research. This data offers great chances for machine learning applications in health care, e.g. for precision medicine, but is also challenging to analyze. Typical challenges include a large number of possibly correlated features and heterogeneity in the data ...
arxiv  

Regulating Sperm Donation: Why Requiring Exposed Donation Is Not the Answer [PDF]

, 2009
[...] the risk of incest and consanguinity11 are prevalent with anonymous donation12 since there is no monitoring of the number of live births per donor.
Pi, Vanessa L.
core   +1 more source

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

Molecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić, Florian Lüke, Steffi Treitschke, Andrea Coluccio, Martin Hoffmann, Giancarlo Feliciello, Adithi Ravikumar Varadarajan, Xin Lu, Kathrin Weidele, Catherine Botteron, Silvia Materna–Reichelt, Felix Keil, Katja Evert, Florian Weber, Thomas Schamberger, Michael Althammer, Jirka Grosse, Dirk Hellwig, Christian Schulz, Stephan Seitz, Peter Ugocsai, Anke Schlenska‐Lange, Roman Mayr, Ulrich Kaiser, Wolfgang Dietmaier, Bernhard Polzer, Jens Warfsmann, Kamran Honarnejad, Tobias Pukrop, Daniel Heudobler, Christoph A. Klein, Christian Werno   +31 more
wiley   +1 more source

Cytomegalovirus Antigenic Mimicry of Human Alloreactive Peptides: A Potential Trigger for Graft versus Host Disease [PDF]

arXiv, 2016
The association between human cytomegalovirus (hCMV) reactivation and the development of graft-versus-host-disease (GVHD) has been observed in stem cell transplantation (SCT). Seventy seven SCT donor-recipient pairs (DRP) (HLA matched unrelated donor (MUD), n=50; matched related donor (MRD), n=27) underwent whole exome sequencing to identify single ...
arxiv  

Physical Examination of Potential Deceased Organ and Tissue Donors: An Overview of the European Landscape. [PDF]

Transpl Int, 2023
Chandrasekar A, Lomas R, Sánchez-Ibáñez J, Lomero M, Bokhorst A, Ivo Da Silva M, Trias E, Pérez Blanco A, Domínguez-Gil B, López-Fraga M.   +9 more
europepmc   +1 more source

Assisted reproductive technology in the USA: is more regulation needed? [PDF]

, 2014
The regulation of assisted reproductive technologies is a contested area. Some jurisdictions, such as the UK and a number of Australian states, have comprehensive regulation of most aspects of assisted reproductive technologies; others, such as the USA ...
Adamson, Allen, ASRM, ASRM, ASRM, ASRM and SART Practice Committee, ASRM Ethics Committee, ASRM Office of Public Affairs, Basu, Cahn, Cahn, Centers for Disease Control and Prevention, Centers for Disease Control and Prevention, Centers for Disease Control and Prevention, Centers for Disease Control and Prevention, Centers for Disease Control and Prevention, Centers for Disease Control and Prevention, Chambers, Cohen, Conrad, D'Orazio, De Neubourg, England and Wales High Court, Eric Blyth, Food and Drug Administration, Gleicher, Gleicher, Gürtin, Hamilton, Heled, HFEA, HFEA, HFEA, HFEA, HFEA, HFEA, Isley, Johnson, Jones, Jungheim, Kalfoglou, Keel, Kushnir, Lewis, Lim, Lucy Frith, Macaldowie, Martin, Ory, Rebar, Sawyer, Sims, Spar, Sunderam, Sylvester, The National Conference of State Legislatures, The National Conference of State Legislatures, The National Conference of State Legislatures, The National Conference of State Legislatures, Tobin, Washington   +60 more
core   +1 more source

Integrative systems‐level analysis reveals a contextual crosstalk between hypoxia and global metabolism in human breast tumors

Molecular Oncology, EarlyView.
Breast tumor samples scored for metabolic deregulation (M1 to M3) were given a hypoxia score (HS). The highest HS occurred in patients with strongest metabolic deregulation (M3), supporting tumor aggressiveness. HS correlated with the highest number of metabolic pathways in M1. This suggests hypoxia to be an early event in metabolic deregulation.
Raefa Abou Khouzam, Salem Chouaib, Mohammad Askandar Iqbal   +2 more
wiley   +1 more source