Results 211 to 220 of about 445,327 (340)

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Characterizing Donor-Derived Cells in Nonhematopoietic Tissue

Biology of Blood and Marrow Transplantation, 2006
Ramakrishnan, Aravind, Shi, Daqing, Torok-Storb, Beverly   +2 more
openaire   +2 more sources

The Study of Oligodendrocyte Pathology Using Postmortem Tissue From Brain Donors Reveals Unique Targets for the Development of Novel Antidepressants

, 2017
Gregory A. Ordway, Attila Szebeni, Liza J. Hernandez, Jessica Crawford, Katalin Szebeni, Michelle Chandley, Katherine C. Burgess, Craig A. Stockmeier, Westley Ongtengco, Hui Wang‐Heaton, Jacob Coulthard, Russell W. Brown   +11 more
openalex   +1 more source

Validation of tissue quality parameters for donor corneas, designated for emergency cases: corneal graft survival [PDF]

, 2009
Wilhelmina J. Rijneveld, Rachel Wolff, H. J. M. Völker-Dieben, Elisabeth Pels   +3 more
openalex   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Retrospective study of COVID-19 seroprevalence among tissue donors at the onset of the outbreak before implementation of strict lockdown measures in France

, 2020
Germain N, Herwegh S, Hatzfeld A, Bocket L, Prévost B, Danze P, Marchetti P.   +6 more
europepmc   +1 more source

216. Development of donor specific chimerism and tolerance in composite tissue allografts under ab-t cell receptor monoclonal antibody and cyclosporine a treatment protocols

, 2003
Dariusz Iżycki, T Osawa, Kağan Özer, Maciej Zieliński, Maria Siemionow   +4 more
openalex   +1 more source

Comparative Transcriptomic Analysis of Cultivated Limbal Epithelium and Donor Corneal Tissue Reveals Altered Wound Healing Gene Expression [PDF]

, 2014
Clair Gallagher, Colin Clarke, Sinéad Aherne, Kishore Reddy Katikireddy, Padraig Doolan, Vincent J. Lynch, Sandra Shaw, Andra Bobart-Hone, Conor C. Murphy, Martin Clynes, William Power, Finbarr O’Sullivan   +11 more
openalex   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source