Results 231 to 240 of about 281,711 (305)

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source

Telomere Dysfunction and Proteostasis Decline Define Distinct Pathways of Cellular Senescence in the Human Respiratory Tract. [PDF]

Aging Cell
Coquette C, Bouchoucha K, Mahieu M, Verleden SE, Loriot A, Norris K, Baird DM, Derumier A, Hoton D, De Sadeleer L, Vanstapel A, Vanaudenaerde BM, Goyet MV, Brichard B, Froidure A, Wuyts W, Van Slambrouck J, Ceulemans LJ, Trigaux W, Huart C, Decottignies A.   +20 more
europepmc   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

What is the optimum incision for superficial temporal artery biopsy? An anatomical study using body donors. [PDF]

Surg Radiol Anat
Vij O, Soon CY, Smith C, Neil M, Fawcett S, Brassett C.   +5 more
europepmc   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Tissue resident memory T cells populate the human uveal tract. [PDF]

Sci Rep
Foers AD, Reekie IR, Wickramasinghe LC, Ward A, Buckley TM, Attar M, Aguilar-Munoa S, Pilapil Q, Elsayed MEA, Pledger S, Bhalla A, Hedley R, Hill S, Windell D, Barton K, Masood I, Lim KS, Coles MC, Sherlock JP, Dick AD, Coupland SE, Sansom SN, Copland DA, Buckley CD, Sharma SM, ORBIT Consortium.   +25 more
europepmc   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Prevotella bivia Influences Antiretroviral Pharmacokinetics and Viral Replication in an Ex Vivo Vaginal Tissue Model. [PDF]

Clin Transl Sci
Lantz AM, Collins LB, Hirsch EB, Staley C, Nicol MR.   +4 more
europepmc   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Harnessing skin-resident γδ T cells for immunotherapy in cutaneous squamous cell carcinoma. [PDF]

Sci Adv
Nasi G, Schöftner LC, Ronacher L, Sophianidis A, Feiser J, Aleksandrova T, Nussbaumer O, Hutton A, Zauner R, Moser-Waxenecker J, Varkhande SR, Sharma A, Ettinger M, Burner T, Laimer M, Guttmann-Gruber C, Gratz IK.   +16 more
europepmc   +1 more source