Results 241 to 250 of about 2,247,754 (308)

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Operational, molecular, and cultural perspectives at the Neurological Foundation Human Brain Bank, New Zealand. [PDF]

Front Neurol
Highet B, Singh-Bains M, Eszes M, Parker R, McShane E, Webb-Robinson C, Hubbard K, Biggins F, Sharma S, Bell P, Burnett O, Lehnert K, Jacobsen JC, Ryan B, Hu M, Turner C, Faull RLM, Curtis MA.   +17 more
europepmc   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Distinct cellular phenotypes of language and executive decline in amyotrophic lateral sclerosis. [PDF]

Cell
Petrescu J, Gouveia Roque C, Jackson CA, Daly AC, Butti Z, Kang K, Casel O, Leung M, Reilly L, Eschbach J, Gebremedhin B, McDade K, Gregory JM, Bonneau R, Smith C, Phatnani H.   +15 more
europepmc   +1 more source

Human lungs maintain tissue-resident memory T cells against a broad spectrum of pathogens. [PDF]

Nat Immunol
Fajardo-Rosas V, Ehtram A, Marchand-Casas I, Chee SJ, Mondal M, Ferrández Alaminos C, Castañeda-Castro FE, Roy Z, Chudley L, Shackcloth M, Cave J, Alzetani A, Woo E, Phillips E, Mallal S, Grifoni A, Schmiedel BJ, Sette A, Peters B, Ottensmeier CH, Vijayanand P.   +20 more
europepmc   +1 more source

Lamin B1 loss in human cardiomyocytes is associated with nuclear shape deformation in dilated cardiomyopathy. [PDF]

J Mol Cell Cardiol Plus
Ventimiglia LN, Zelezniak A, Dos Remedios CG, Lal S, Ehler E, De Nicola GF.   +5 more
europepmc   +1 more source

From diagnosis to refusal-causes and barriers to organ donation after brain death: a cross-sectional study. [PDF]

Sao Paulo Med J
Victorino JP, Campos Junior VP, Monteiro VNV, Mendes KDS, Brito ES, Ventura CA.   +5 more
europepmc   +1 more source

Genetic subtypes of multiple sclerosis severity are uncoupled from inflammatory lesion burden. [PDF]

Acta Neuropathol
Abbadessa G, Kreft KL, Howell O, de Oliveira JVC, Cooze B, Papadaki A, Jacinto JM, Farkas I, Leung YY, Bonavita S, Tallantyre EC, Robertson NP, Nagano A, Rizig M, Magliozzi R, Owen D, Reynolds R, Nicholas R.   +17 more
europepmc   +1 more source