Results 261 to 270 of about 445,327 (340)

Properties of an α-D-galactosyltransferase in human tissues obtained in blood-group B donors

, 1969
Caroline Race, Winifred M. Watkins
openalex   +2 more sources

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Histological analysis of age-related degeneration in human female and male knee cartilage and meniscus. [PDF]

Osteoarthr Cartil Open
Sjögren A, Bodahl S, Hughes V, Turkiewicz A, Aspberg A, Hellberg I, Karjalainen VP, Ali N, Önnerfjord P, Englund M.   +9 more
europepmc   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

Small things matter: Lack of extraislet β cells in type 1 diabetes. [PDF]

Sci Adv
Murrall K, Luckett T, Lekka C, Flaxman CS, Wyatt R, Akhbari P, Kusmartseva I, Hunter SL, Leete P, Burn I, Osokina E, EXE-T1D Consortium, Shaw JAM, Morgan NG, Richardson SJ.   +14 more
europepmc   +1 more source

The Importance of Reconstituting the Bodies of Organ and Tissue Donors: a Look at Human Dignity

Carlos Alexandre Curylofo Corsi, Alan Vinícius Assunção-Luiz, Leonardo Monteiro-Silva, Katia Carmen Gabriel Scarpelini, Mayara Segundo Ribeiro, Flávio Luís Garcia, Luís Gustavo Gazoni Martins, Rodolfo Leandro Bento   +7 more
openalex   +2 more sources

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source

Maximizing Lung Transplant Donor Utilization: Developing a Lobar Donor Repository Guided by Chest Computed Tomography Visual Scoring. [PDF]

Interdiscip Cardiovasc Thorac Surg
Liu M, Xi L, Luo C, Li X, Yang C, Peng G, Xu X.   +6 more
europepmc   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Microbiological risk assessment during the procurement and processing of cells, tissues and breast milk using the MiRCA tool. [PDF]

Sci Rep
Jandová M, Rudolfová Š, Švorcová M, Měřička P.   +3 more
europepmc   +1 more source