Results 181 to 190 of about 3,873,709 (285)

Skin Seed Amplification Assay Differentiates Multiple System Atrophy from Parkinson's Disease

open access: yesMovement Disorders, EarlyView.
Abstract Background Misdiagnoses of multiple system atrophy (MSA) and Parkinson's disease (PD) remain common. Objective The objective of the study was to develop a skin α‐synuclein seed amplification assay (αSyn‐SAA) for detecting pathological α‐synuclein and distinguishing MSA from PD.
Anastasia Kuzkina   +23 more
wiley   +1 more source

AI‐Driven Rational Design of Nanotherapeutics for Pancreatic Ductal Adenocarcinoma

open access: yesMedicinal Research Reviews, EarlyView.
ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) remains a formidable malignancy characterized by late diagnosis, high recurrence rates, and pronounced chemoresistance. While nanoparticle‐based drug delivery systems (NDDS) offer theoretical advantages over conventional therapies, their clinical translation in PDAC has been severely limited.
Seohyun Choo   +4 more
wiley   +1 more source

QQ‐Based Oxygen Extraction Fraction (OEF) Mapping in Mouse Brain: Initial Experience

open access: yesMagnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose Oxygen extraction fraction (OEF) is a vital biomarker of cerebral oxygen metabolism and tissue viability. A novel OEF mapping method, QQ, which combines quantitative susceptibility mapping (QSM) and quantitative blood oxygen level‐dependent (qBOLD) (QSM + qBOLD = QQ), has demonstrated promise in detecting disease‐related OEF ...
Quinn Boyer   +4 more
wiley   +1 more source

Whole‐Brain Cerebral Microvascular Pulsatility Imaging Using Dynamic pCASL MRI With Segmented Stack‐of‐Stars Golden‐Angle Radial Acquisition

open access: yesMagnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To develop an efficient dynamic pseudo‐continuous arterial spin labeling (pCASL) MRI technique for whole‐brain microvascular flow pulsatility imaging. Methods The proposed technique combines pCASL with a segmented stack‐of‐stars golden‐angle radial acquisition.
Tianrui Zhao   +5 more
wiley   +1 more source

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