Results 171 to 180 of about 1,261,489 (334)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Evaluating and improving biocompatibility of conductive polymers for cardiac tissue engineering. [PDF]
J Mater Chem BAboagye J +4 more
europepmc +1 more source
Geometrically Controlled Liquefied Capsules for Modular Tissue Engineering Strategies
, 2020 Sara Nadine +5 more
openalex +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Is tissue engineering finally ready? The second wave of tissue engineering and its implications for oral and maxillofacial reconstruction surgery. [PDF]
J Korean Assoc Oral Maxillofac SurgPark JY.
europepmc +1 more source
Development of an oxygen-sensitive hydrogel for monitoring oxygen diffusion in tissue engineering
Ehlers, Lisa +2 more
openalex +1 more source