Results 171 to 180 of about 614,474 (290)

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Biomimetic materials: a promising strategy for periodontal tissue engineering and regeneration. [PDF]

Front Bioeng Biotechnol
Zhang Q, Gou C, Zhang Z.
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Nanofiber scaffold for bone tissue engineering: Mechanism, challenge and future prospect. [PDF]

World J Orthop
Wen RM, Wang HX, Liu ZJ, Duan ZQ.
europepmc   +1 more source

Historical background of regenerative medicine and tissue engineering

, 2021
Rita Varga
openalex   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Click Chemistry-Based Hydrogels for Tissue Engineering. [PDF]

Gels
Sojdeh S, Panjipour A, Yaghmour A, Arabpour Z, Djalilian AR.   +4 more
europepmc   +1 more source

Rapid tissue engineering of biomimetic human corneal limbal crypts with 3D niche architecture

, 2013
Hannah J. Levis, Isobel Massie, Marc Dziasko, Andreas Kaasi, Julie T. Daniels   +4 more
openalex   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Editorial: Effect of mechanical loading on the tendon for tissue engineering approaches. [PDF]

Front Bioeng Biotechnol
Gögele C, Tempfer H, Tohidnezhad M, Jenner F, Docheva D.   +4 more
europepmc   +1 more source