Results 171 to 180 of about 166,368,995 (207)

Connective tissue growth factor increases matrix metalloproteinase‐2 and suppresses tissue inhibitor of matrix metalloproteinase‐2 production by cultured renal interstitial fibroblasts

Wound Repair and Regeneration, 2007
ABSTRACTThe involvement of gelatinase (matrix metalloproteinase‐2 [MMP‐2] and MMP‐9) in the matrix remodeling and development of tubulointerstitial fibrosis has been studied recently, but relatively little is known about the regulators and the mechanisms controlling the activation and expression of gelatinase in renal fibroblasts. In these studies, the
Min, Yang, Haichang, Huang, Jingzi, Li, Wen, Huang, Haiyan, Wang   +4 more
openaire   +2 more sources

Tissue inhibitor of matrix metalloproteinase-2 in nasopharyngeal carcinoma.

MedGenMed : Medscape general medicine, 2008
By regulating matrix metalloproteinase (MMP) activity and controlling the breakdown of extracellular matrix components, tissue inhibitors of metalloproteinases (TIMPs) play an important role in the process of tumor invasion and metastasis. The present study was designed to clarify the role of TIMP-2 in nasopharyngeal carcinoma (NPC) patients and to ...
Amr Ahmed, El Badry, Amal Abou, El-Fadle, Abdel Latif, El-Balshy   +2 more
openaire   +1 more source

Serum levels of tissue inhibitor of metalloproteinases‐2 and of precursor form of matrix metalloproteinase‐2 in patients with liver disease

Liver, 1997
Abstract: Serum levels of tissue inhibitor of metalloproteinases‐2 (TIMP2) and of precursor form of matrix metalloproteinase‐2 (proMMP2) were determined in patients with chronic hepatitis and hepatocellular carcinoma by a one‐step sandwich enzyme immunoassay.
M, Ebata, Y, Fukuda, I, Nakano, Y, Katano, N, Fujimoto, T, Hayakawa   +5 more
openaire   +2 more sources

Presence of matrix metalloproteinase–2 and tissue inhibitor matrix metalloproteinase–2 gene polymorphisms and immunohistochemical expressions in intracranial meningiomas

Journal of Neurosurgery, 2014
Object Meningiomas are benign extraaxial tumors with a slow progression. Some of them, in spite of being benign in nature, may show an aggressive progression pattern. To investigate the behavioral characteristics of meningiomas, researchers have studied matrix metalloproteinases (MMPs), their tissue inhibitors (TIMPs), interstitial collagens, proteins,
İlker Coven, Ozge Ozer, Ozlem Ozen, Feride İffet Şahin, Nur Altinors   +4 more
openaire   +1 more source

Connective Tissue Growth Factor and Tissue Inhibitor of Matrix Metalloproteinase-2 in Patients with Exfoliative Glaucoma

Current Eye Research, 2011
To investigate the aqueous humor levels of connective tissue growth factor (CTGF), matrix metalloprotinease-2 (MMP-2), and tissue inhibitor of matrix metalloprotinease-2 (TIMP-2) in human eyes with exfoliative glaucoma, primary open-angle glaucoma, and senile cataract patients.This was a prospective, comparative study. Sixty patients with glaucomas and
Asaad A, Ghanem, Lamiaa F, Arafa, Ayman, El-Baz   +2 more
openaire   +2 more sources

Matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 expression and synthetic matrix metalloproteinase-2 inhibitor binding in ovarian carcinomas and tumor cell lines.

Laboratory investigation; a journal of technical methods and pathology, 1997
Enhanced matrix metalloproteinase-2 (MMP-2/72-kd type IV collagenase) action correlates with invasion in neoplasia. MMP-2 is inhibited in vivo by tissue inhibitors of metalloproteinases (TIMPs)-TIMP-1 and, especially, TIMP-2. A synthetic, biotinylated inhibitor specific for activated MMP-2 in solution phase, and immunohistochemistry were used to detect
Afzal, Saliha, Lalani, El-Nasir, Foulkes, William D, Boyce, B, Tickle, Simon, Cardillo, M R, Baker, T S, Pignatelli, M, Stamp, Gordon   +8 more
openaire   +1 more source

Significant Relation of Tissue Inhibitor of Matrix Metalloproteinase-2 and Its Combination With Matrix Metalloproteinase-2 to Survival of Patients With Cancer of Uterine Cervix

Reproductive Sciences, 2011
Tissue inhibitor of matrix metalloproteinase-2 (TIMP-2) has high affinity for matrix metalloproteinase-2 (MMP-2). Few studies simultaneously investigate their implication in prognosis of patients with cervical cancer. We used reverse transcription-polymerase chain reaction and immunohistochemical method for cervical tissues and microarrays to ...
Po-Hui, Wang, Jiunn-Liang, Ko, Shun-Fa, Yang, Hsiu-Ting, Tsai, Yi-Torng, Tee, Chih-Ping, Han, Long-Yau, Lin, Shiuan-Chih, Chen, Yang-Tse, Shih   +8 more
openaire   +2 more sources

[Association of polymorphism in matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 with genetic susceptibility of gastric cancer].

Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine], 2013
This study was to explore the correlations between genetic variants in MMP2-1306C/T, TIMP2 2379C/T, TIMP2 303G/A and the genetic susceptibility to gastric carcinoma (GC) in Fujian province, China.A case-control study was conducted. Polymorphisms of MMP2-1306C/T, TIMP2 2379C/T, TIMP2 303G/A in 479 gastric carcinoma patients and 469 cancer-free controls,
Xian-dong, Lin, Gang, Chen, Chao, Li, Li-yuan, Zhang, Yi, Shi, Dong-mei, Zhou, Xiong-wei, Zheng   +6 more
openaire   +2 more sources