Results 1 to 10 of about 700,907 (294)

Amelioration of Pulmonary Fibrosis by Matrix Metalloproteinase-2 Overexpression. [PDF]

Int J Mol Sci, 2023
Idiopathic pulmonary fibrosis is a progressive and fatal disease with a poor prognosis. Matrix metalloproteinase-2 is involved in the pathogenesis of organ fibrosis. The role of matrix metalloproteinase-2 in lung fibrosis is unclear. This study evaluated
Inoue R, Yasuma T, Fridman D'Alessandro V, Toda M, Ito T, Tomaru A, D'Alessandro-Gabazza CN, Tsuruga T, Okano T, Takeshita A, Nishihama K, Fujimoto H, Kobayashi T, Gabazza EC.   +13 more
europepmc   +2 more sources

Protective Role of Matrix Metalloproteinase-2 in Allergic Bronchial Asthma

Frontiers in Immunology, 2019
Inflammation, reversible obstruction, and hyperresponsiveness of the airways are characteristic findings of bronchial asthma. Several evidence has demonstrated the involvement of matrix metalloproteinase-2 in allergic airway inflammation.
Yoshinori Takahashi, Tetsu Kobayashi, Corina N. D'Alessandro-Gabazza, Masaaki Toda, Kentaro Fujiwara, Tomohito Okano, Hajime Fujimoto, Kentaro Asayama, Atsuro Takeshita, Atsuro Takeshita, Taro Yasuma, Taro Yasuma, Kota Nishihama, Ryo Inoue, Liqiang Qin, Yoshiyuki Takei, Osamu Taguchi, Esteban C. Gabazza   +17 more
doaj   +2 more sources

Matrix Metalloproteinase 2 as a Pharmacological Target in Heart Failure

Pharmaceuticals, 2022
Heart failure (HF) is an acute or chronic clinical syndrome that results in a decrease in cardiac output and an increase in intracardiac pressure at rest or upon exertion.
Pricila Rodrigues Gonçalves, Lisandra Duarte Nascimento, Raquel Fernanda Gerlach, Keuri Eleutério Rodrigues, Alejandro Ferraz Prado   +4 more
doaj   +2 more sources

Role of Matrix Metalloproteinase-2 in Eosinophil-Mediated Airway Remodeling

Frontiers in Immunology, 2018
Airway remodeling is responsible for the progressive decline of lung function in bronchial asthma. Matrix metalloproteinase-2 and fibroblast-to-myofibroblast transition are involved in tissue remodeling.
Yu Kuwabara, Tetsu Kobayashi, Corina N. D'Alessandro-Gabazza, Masaaki Toda, Taro Yasuma, Kota Nishihama, Atsuro Takeshita, Hajime Fujimoto, Mizuho Nagao, Takao Fujisawa, Esteban C. Gabazza   +10 more
doaj   +2 more sources

Matrix Metalloproteinase 2 Measurement [PDF]

Definitions, 2020
The determination of the amount of matrix metalloproteinase 2 present in a sample.

semanticscholar   +2 more sources

The Complex Role of Matrix Metalloproteinase-2 (MMP-2) in Health and Disease. [PDF]

Int J Mol Sci
Matrix metalloproteinase-2 (MMP-2), a zinc-dependent enzyme, plays a critical role in the degradation and remodeling of the extracellular matrix (ECM). As a member of the gelatinase subgroup of matrix metalloproteinases, MMP-2 is involved in a variety of
Wolosowicz M, Prokopiuk S, Kaminski TW.
europepmc   +2 more sources

Development of Matrix Metalloproteinase-2 Inhibitors for Cardioprotection [PDF]

Frontiers in Pharmacology, 2018
The objective of our present study is to develop novel inhibitors for MMP-2 for acute cardioprotection. In a series of pilot studies, novel substituted carboxylic acid derivatives were synthesized based on imidazole and thiazole scaffolds and then tested
Péter Bencsik, Péter Bencsik, Krisztina Kupai, Anikó Görbe, Anikó Görbe, Éva Kenyeres, Éva Kenyeres, Zoltán V. Varga, János Pálóczi, Renáta Gáspár, László Kovács, Lutz Weber, Ferenc Takács, István Hajdú, István Hajdú, Gabriella Fabó, Sándor Cseh, László Barna, László Barna, Tamás Csont, Csaba Csonka, György Dormán, Péter Ferdinandy, Péter Ferdinandy   +23 more
doaj   +5 more sources

Matrix metalloproteinase-2: Not (just) a "hero" of the past.

Biochimie, 2019
The 72-kDa type IV collagenase or gelatinase A is the second member of the matrix metalloproteinase family, MMP-2. Since the discovery of its first two substrates within components of the extracellular matrix, denatured interstitial type I collagen and ...
P. Henriet, H. Emonard
semanticscholar   +4 more sources

Anacardic Acid Inhibits the Catalytic Activity of Matrix Metalloproteinase-2 and Matrix Metalloproteinase-9 [PDF]

Molecular Pharmacology, 2012
Cashew nut shell liquid (CNSL) has been used in traditional medicine for the treatment of a wide variety of pathophysiological conditions. To further define the mechanism of CNSL action, we investigated the effect of cashew nut shell extract (CNSE) on two matrix metalloproteinases, MMP-2/gelatinase A and MMP-9/gelatinase B, which are known to have ...
Athira Omanakuttan, Jyotsna Nambiar, Rodney Harris, Chinchu Bose, N. Pandurangan, Rebu K. Varghese, G. Kumar, J. Tainer, A. Banerji, J. Perry, B. G. Nair   +10 more
semanticscholar   +3 more sources

Investigating salivary matrix metalloproteinase-2 and matrix metalloproteinase-9 activity in fixed orthodontic-induced gingival enlargement [PDF]

Dental Research Journal
Background: Gingival enlargement (GE) is a common clinical observation among orthodontic patients, yet its underlying causes remain unclear. This study aims to investigate the potential involvement of salivary matrix metalloproteinase (MMP)-2 and MMP-9 ...
Narges Ziaei, Amir Kiani, Ehsan Mohammadi-Noori, Shahram Arishi, Shima Golmohammadi   +4 more
doaj   +2 more sources