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Matrix metalloproteinases in emphysema [PDF]
Matrix Biology, 2018 Several studies have implicated a causative role for specific matrix metalloproteinases (MMPs) in the development and progression of cigarette smoke-induced chronic obstructive pulmonary disease (COPD) and its severe sequela, emphysema. However, the precise function of any given MMP in emphysema remains an unanswered question.
Sina A, Gharib +2 more
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Matrix metalloproteinases in lung biology
Respiratory Research, 2000 Despite much information on their catalytic properties and gene regulation, we actually know very little of what matrix metalloproteinases (MMPs) do in tissues.
Parks William C, Shapiro Steven D
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Zaporožskij Medicinskij Žurnal, 2014 Aim. Matrix metalloproteinases play a key role in adaptive postinfarction remodeling of the heart. In order to study the influence of anticoagulation therapy on the state of matrix metalloproteinases and their inhibitors, the incidence of post-infarction
S. M. Kyselov
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Matrix metalloproteinases in cancer
Essays in Biochemistry, 2002 The extracellular matrix (ECM) holds cells together and maintains the three-dimensional structure of the body. It also plays critical roles in cell growth, differentiation, survival and motility. For a tumour cell to metastasize from the primary tumour to other organs, it must locally degrade ECM components that are the physical barriers for cell ...
Itoh, Y, Nagase, H
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Role of matrix metalloproteinase in the aneurismatic aortic disease
Monaldi Archives for Chest Disease, 2004 The aorta is involved in a large variety of diseases and the atherosclerotic aneurysms represent the most common type of these. Recent reports have attempted to clarify the mechanisms, that cause the formation and the progression of the atherosclerotic ...
Nicola Troisi +3 more
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Thermal stability of human matrix metalloproteinases
Heliyon, 2020 Matrix metalloproteinases (MMP) are key players in the remodelling of the extracellular matrix under physiological and pathological conditions. Thermodynamic parameters of human recombinant metalloproteinases of the active (rMMP2, 3, 7, 8 and 9) and ...
Noemi Meraz-Cruz +3 more
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MMP2 and MMP9 contribute to lung ischemia–reperfusion injury via promoting pyroptosis in mice
BMC Pulmonary Medicine, 2022 Background Lung ischemia–reperfusion injury (LIRI) is a cause of poor prognosis in several lung diseases and after lung transplantation. In LIRI, matrix metalloproteinases and pyroptosis indicators change in parallel, both of them involvement of ...
Peng Zhou +4 more
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Targeting matrix metalloproteinase MMP3 greatly enhances oncolytic virus mediated tumor therapy
Translational Oncology, 2021 In cancer, the extracellular matrix is extensively remodeled during chronic inflammation, thus affecting cell transcription, differentiation, migration and cell-cell interactions.
Minglong Liang +8 more
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Matrix metalloproteinases in neuroinflammation [PDF]
Glia, 2002 AbstractMatrix metalloproteinases (MMPs) are a gene family of neutral proteases that are important in normal development, wound healing, and a wide variety of pathological processes, including the spread of metastatic cancer cells, arthritic destruction of joints, atherosclerosis, and neuroinflammation.
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Matrix Metalloproteinases in Health and Disease
Biomolecules, 2020 Matrix metalloproteinases (MMPs) are members of an enzyme family and, under normal physiological conditions, are critical for maintaining tissue allostasis [...]
Raffaele Serra
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