Results 1 to 10 of about 2,668,478 (162)
Challenges in Matrix Metalloproteinases Inhibition
Biomolecules, 2020 Matrix metalloproteinases are enzymes that degrade the extracellular matrix. They have different substrates but similar structural organization. Matrix metalloproteinases are involved in many physiological and pathological processes and there is a need ...
Helena Laronha +7 more
doaj +4 more sources
The Roles of Matrix Metalloproteinases and Their Inhibitors in Human Diseases
International Journal of Molecular Sciences, 2020 Matrix metalloproteinases (MMPs) are a family of zinc-dependent extracellular matrix (ECM) remodeling endopeptidases that have the capacity to degrade almost every component of the ECM.
Claudia Castruita-De la Rosa +2 more
exaly +2 more sources
Structure and Function of Human Matrix Metalloproteinases
Cells, 2020 The extracellular matrix (ECM) is a macromolecules network, in which the most abundant molecule is collagen. This protein in triple helical conformation is highly resistant to proteinases degradation, the only enzymes capable of degrading the collagen ...
Jorge Caldeira, Helena Laronha
exaly +2 more sources
Journal of Orofacial Sciences, 2010 Matrix metalloproteinases (MMPs), also known as matrixins, belong to a group of zinc-dependent proteins, which are thought to play a central role in the breakdown of extracellular matrix. Collagen, elastin, gelatin and casein are major components cleaved
S Sahitya +2 more
doaj +2 more sources
Matrix Metalloproteinases and Glaucoma
Biomolecules, 2022 Matrix metalloproteinases (MMPs) are enzymes that decompose extracellular matrix (ECM) proteins. MMPs are thought to play important roles in cellular processes, such as cell proliferation, differentiation, angiogenesis, migration, apoptosis, and host ...
Moo Hyun Kim, Su-Ho Lim
doaj +1 more source
Pharmacological Reviews, 2022 The first matrix metalloproteinase (MMP) was discovered in 1962 from the tail of a tadpole by its ability to degrade collagen. As their name suggests, matrix metalloproteinases are proteases capable of remodeling the extracellular matrix.
L. D. de Almeida +7 more
semanticscholar +1 more source
Biomedicines, 2021 Collagen cleavage by matrix metalloproteinase (MMP) is considered a major cause of dental resins long term failure. Most MMP inhibitors display significant toxicity and are unsuitable for dental resins’ applications. Here we report a study of a new class
Helena Laronha +8 more
doaj +1 more source
Matrix Metalloproteinases Shape the Tumor Microenvironment in Cancer Progression
International Journal of Molecular Sciences, 2021 Cancer progression with uncontrolled tumor growth, local invasion, and metastasis depends largely on the proteolytic activity of numerous matrix metalloproteinases (MMPs), which affect tissue integrity, immune cell recruitment, and tissue turnover by ...
S. Niland +2 more
semanticscholar +1 more source
Matrix metalloproteinases-9 and tissue inhibitor of matrix metalloproteinases-1 in sarcoidosis patients [PDF]
Arhiv za farmaciju, 2017 Matrix metaloproteinases (MMPs) and their specific inhibitors - tissue inhibitors of matrix metalloproteinases (TIMPs) play an important role in pulmonary extracellular matrix destruction. Sarcoidosis is an inflammatory disease affecting multiple organs.
Ivanišević Jasmina +6 more
doaj +1 more source
Multifunctional intracellular matrix metalloproteinases: implications in disease
The FEBS Journal, 2021 Matrix metalloproteinases (MMPs) are zinc‐dependent endopeptidases that were first discovered as proteases, which target and cleave extracellular proteins. During the past 20 years, however, intracellular roles of MMPs were uncovered and research on this
Wesam Bassiouni +2 more
semanticscholar +1 more source