Results 31 to 40 of about 116,965 (260)

Immunomodulatory role of metalloproteases in cancers: Current progress and future trends

Frontiers in Immunology, 2022
Metalloproteinases (MPs) is a large family of proteinases with metal ions in their active centers. According to the different domains metalloproteinases can be divided into a variety of subtypes mainly including Matrix Metalloproteinases (MMPs), A ...
Qi Wang, Kai Wang, Xiaojing Tan, Zhenxiang Li, Haiyong Wang   +4 more
doaj   +1 more source

Disparate Remodeling of the Extracellular Matrix and Proteoglycans in Failing Pediatric Versus Adult Hearts

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
Background Dilated cardiomyopathy (DCM) is a common cause of heart failure in adult and pediatric patients, but the underlying mechanism may vary in adults and children, with few studies conducted to date.
Sayantan Jana, Hao Zhang, Gary D. Lopaschuk, Darren H. Freed, Consolato Sergi, Paul F. Kantor, Gavin Y. Oudit, Zamaneh Kassiri   +7 more
doaj   +1 more source

The possibilities of using the inhibitors of matrix metalloproteinases for keratoplasty

Трансплантология (Москва), 2023
Introduction. The review is devoted to the actual problem of treating patients with keratolysis. The role of matrix metalloproteinases in the pathogenesis of cornea and corneal graft melting is discussed as well as the practical experience of using ...
K. V. Sirotkina, E. V. Chentsova
doaj   +1 more source

Matrix metalloproteinases and angiogenesis [PDF]

Journal of Cellular and Molecular Medicine, 2005
Matrix metalloproteinases (MMPs) are a family of enzymes that proteolytically degrade various components of the extracellular matrix (ECM). Angiogenesis is the process of forming new blood vessels from existing ones and requires degradation of the vascular basement membrane and remodeling of the ECM in order to allow endothelial cells to migrate and ...
openaire   +2 more sources

Matrix Metalloproteinases and the Pathogenesis of Recurrent Corneal Erosions and Epithelial Basement Membrane Dystrophy

Biology, 2023
Matrix metalloproteinases (MMPs) are a group of proteolytic enzymes which are members of the zinc endopeptidase family. They have the ability to degrade extracellular matrix elements, allowing for the release of binding molecules and cell migration ...
Katarzyna Jadczyk-Sorek, Wojciech Garczorz, Beata Bubała-Stachowicz, Tomasz Francuz, Ewa Mrukwa-Kominek   +4 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Multifaceted role of Matrix Metalloproteinases (MMPs)

Frontiers in Molecular Biosciences, 2015
Matrix metalloproteinases (MMPs), a large family of calcium-dependent zinc-containing endopeptidases, are involved the tissue remodeling and degradation of the extracellular matrix.
Divya eSingh, Sanjeev Kumar Srivastava, Tapas K Chaudhuri, Ghanshyam eUpadhyay   +3 more
doaj   +1 more source

Anti-MMP-2 and MMP-9 activity of Salsola komarovii Iljin extract and its solvent fractions

Asian Pacific Journal of Tropical Biomedicine, 2020
Objective: To investigate matrix metalloproteinases (MMP)-2 and MMP-9 inhibitory effect of Salsola komarovii Iljin, an edible halophyte with health beneficial effects. Methods: Salsola komarovii crude extracts (SKI), and solvent (n-hexane, 85% aq.
Jung-Ha Kil, Fatih Karadeniz, Ga Hyun Yu, Hojun Kim, Junse Kim, Jung Hwan Oh, Jung Im Lee, Chang-Suk Kong, Youngwan Seo   +8 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Are matrix metalloproteinases the missing link? [PDF]

Invertebrate Survival Journal, 2005
It is more and more evident that the matrix metalloproteinase (MMP) system is not a characteristicfeature of vertebrate animals only, as it can also be found in many invertebrate organisms. Thisendopeptidase family has been widely studied since its first
F Mannello, G Tonti, S Papa
doaj   +2 more sources