It Takes Two to Tango: Current Understanding of the Role of M16 Family of Proteases and Their Structural Properties [PDF]
BiomoleculesThe M16 protease family comprises metalloendopeptidases, characterized by a unique molecular architecture. The active enzyme molecule is composed of two halves, which together form a structure resembling a clam shell.
Miroslaw Jarzab, Joanna Skorko-Glonek
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Production and application of peptidyl-lys metalloendopeptidase: advances, challenges, and future perspectives [PDF]
Applied Microbiology and BiotechnologyPeptidyl-lys metalloendopeptidases (PKMs) are enzymes that selectively cleave peptide bonds at the N-terminus of lysine residues present in the P1′ position, making them valuable tools in proteomics.
Uzair Ahmed +2 more
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The astacin family of metalloendopeptidases [PDF]
Protein Science, 1995 AbstractThe astacin family of metalloendopeptidases was recognized as a novel family of proteases in the 1990s. The crayfish enzyme astacin was the first characterized and is one of the smallest members of the family. More than 20 members of the family have now been identified.
Robert J. Beynon
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Families of metalloendopeptidases and their relationships [PDF]
FEBS Letters, 1992 Crystal structures available for four metalloendopeptidases have revealed zinc ligands for these enzymes. New sequence information has made it possible to compare the primary structures of the zinc‐binding site in metalloendopeptidases. A scheme based on the zinc‐binding site is proposed to classify metalloendopeptidases into five distinct families ...
Jiang, Weiping, Bond, Judith S.
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The ADAMTS family: from extracellular matrix proteases to orchestrators of fibrosis [PDF]
Cell Communication and SignalingFibrosis, a pathological process defined by excessive extracellular matrix (ECM) accumulation, contributes significantly to chronic organ failure worldwide.
Yang Yuan +4 more
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Soluble Metalloendopeptidases and Neuroendocrine Signaling [PDF]
Endocrine Reviews, 2002 Peptidases play a vital and often highly specific role in the physiological and pathological generation and termination of peptide hormone signals. The thermolysin-like family of metalloendopeptidases involved in the extracellular processing of neuroendocrine and cardiovascular peptides are of particular significance, reflecting both their specificity ...
Corie N, Shrimpton +2 more
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Homologues of insulinase, a new superfamily of metalloendopeptidases [PDF]
Biochemical Journal, 1991 On the basis of a statistical analysis of an alignment of the amino acid sequences, a new superfamily of metalloendopeptidases is proposed, consisting of human insulinase, Escherichia coli protease III and mitochondrial processing endopeptidases from Saccharomyces and Neurospora.
Neil David Rawlings, Alan J. Barrett
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Journal of Oral Biology and Craniofacial Research, 2023 Salivary gland (SG) extracellular matrix (ECM) has a major influence on tissue development, homeostasis, and tissue regeneration after injury. During aging, disease, and physical insult, normal remodeling of the SG microenvironment (i.e.
Milos Marinkovic +6 more
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gone early, a novel germline factor, ensures the proper size of the stem cell precursor pool in the Drosophila ovary. [PDF]
PLoS ONE, 2014 In order to sustain lifelong production of gametes, many animals have evolved a stem cell-based gametogenic program. In the Drosophila ovary, germline stem cells (GSCs) arise from a pool of primordial germ cells (PGCs) that remain undifferentiated even ...
Shinya Matsuoka +4 more
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Specific fluorogenic substrates for neprilysin (neutral endopeptidase, EC 3.4.24.11) which are highly resistant to serine- and metalloproteases [PDF]
, 1997 Two intramolecularly quenched fluorogenic peptides containing o-aminobenzoyl (Abz) and ethylenediamine 2,4-dinitrophenyl (EDDnp) groups at amino- and carboxyl-terminal amino acid residues, Abz-DArg-Arg-Leu-EDDnp (Abz-DRRL-EDDnp) and Abz-DArg-Arg-Phe ...
Boileau, G. +4 more
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