Results 21 to 30 of about 4,257 (183)

Nonparametric Pathway-Based Regression Models for Analysis of Genomic Data [PDF]

, 2006
High-throughout genomic data provide an opportunity for identifying pathways and genes that are related to various clinical phenotypes. Besides these genomic data, another valuable source of data is the biological knowledge about genes and pathways that ...
Li, Hongzhe, Wei, Zhi
core   +2 more sources

Stepwise metamorphosis of the tubeworm Hydroides elegans is mediated by a bacterial inducer and MAPK signaling [PDF]

, 2016
Diverse animal taxa metamorphose between larval and juvenile phases in response to bacteria. Although bacteria-induced metamorphosis is widespread among metazoans, little is known about the molecular changes that occur in the animal upon stimulation by ...
Antoshechkin, Igor, Medeiros, João M., Newman, Dianne K., Pilhofer, Martin, Shikuma, Nicholas J.   +4 more
core   +2 more sources

Gene expression and matrix turnover in overused and damaged tendons [PDF]

, 2005
Chronic, painful conditions affecting tendons, frequently known as tendinopathy, are very common types of sporting injury. The tendon extracellular matrix is substantially altered in tendinopathy, and these changes are thought to precede and underlie the
Abbaszade I, Akeson WH, Alfredson H, Amiel D, Archambault J, Astrom M, Bank RA, Banyard J, Benjamin M., Berenson MC, Boot-Handford RP, Brown PD., Cal S, Caterson B, Cawston TE, Cawston TE., Clark IM, Colige A, Colige A, Collins-Racie LA, Corps AN, Corps AN, Curwin SL, Dalton S, Dickinson SC, Eriksen HA, Everts V, Fernandes RJ, Fitzgerald J, Flannery CR, G. P. Riley, Gao G, Gelberman RH, Gillard GC, Gotoh M, Hannafin JA., Hardingham TE, Hashimoto T, Heinemeier K, Ireland D, Jarvinen M, Jozsa L, Jozsa L, Kannus P, Kannus P., Kannus P., Kashiwagi M, Kashiwagi M, Kaushal GP, Kjaer M, Koch M, Koch M, Koshy PJ, Koskinen SO, Kuno K, Langberg H, Langberg H, Langberg H, Leadbetter WB., Lehto M, McCawley LJ, McNeilly CM, Murphy G, Myllyharju J, Nagase H., Pace JM, Patterson-Kane JC, Pierfitte C, Rees SG, Riley G., Riley GP, Riley GP, Riley GP, Riley GP, Riley GP, Riley GP., Samiric T, Samiric T, Sandy JD, Sandy JD, Sandy JD, Sato K, Smith RK, Smith RK, Somerville RP, Tipton CM, Tortorella MD, Tortorella MD, Tsuzaki M, Vankemmelbeke MN, Vogel KG, Waggett AD, Wang P, Woo SLY, Woo SLY, Woo SLY, Yasuda K, Yoshihara Y   +97 more
core   +1 more source

Characterization of a New M13 Metallopeptidase from Deep-Sea Shewanella sp. E525-6 and Mechanistic Insight into Its Catalysis [PDF]

, 2016
Bacterial extracellular peptidases are important for bacterial nutrition and organic nitrogen degradation in the ocean. While many peptidases of the M13 family from terrestrial animals and bacteria are studied, there has been no report on M13 peptidases ...
Bai-Cheng Zhou, Bin-Bin Xie, Chun-Yang Li, Jin-Yu Yang, Peng Wang, Sheng Dong, Xi-Ying Zhang, Xiao-Yan Song, Xiu-Lan Chen, Yu-Zhong Zhang   +9 more
core   +2 more sources

A Novel Hyaluronidase from Brown Spider (Loxosceles intermedia) Venom (Dietrich's Hyaluronidase): From Cloning to Functional Characterization [PDF]

, 2013
Loxoscelism is the designation given to clinical symptoms evoked by Loxosceles spider's bites. Clinical manifestations include skin necrosis with gravitational spreading and systemic disturbs. the venom contains several enzymatic toxins.
Chaim, Olga Meiri, Ferrer, Valeria Pereira, Gremski, Luiza Helena, Gremski, Waldemiro, Mari, Thiago Lopes de, Nader, Helena Bonciani, Senff-Ribeiro, Andrea, Silva, Dilza Trevisan, Silveira, Rafael Bertoni da, Veiga, Silvio Sanches   +9 more
core   +9 more sources

Enzyme contribution of non-Saccharomyces yeasts to wine production [PDF]

, 2015
The fermentation of grape must to produce wine is a biologically complex process, carried on by yeasts and malolactic bacteria. The yeasts present in spontaneous fermentation may be divided into two groups, the Saccharomyces yeasts, particularly S ...
Maicas i Prieto, Sergi, Mateo Tolosa, José Juan   +1 more
core   +2 more sources

Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins. [PDF]

, 2016
AIMS: Extracellular matrix remodelling has been implicated in a number of vascular conditions, including venous hypertension and varicose veins. However, to date, no systematic analysis of matrix remodelling in human veins has been performed. METHODS AND
David N. Potier, Ferheen Baig, Hassan Albadawi, Javier Barallobre-Barreiro, Julianne Stoughton, Karen E. Porter, Kucukguven, Manuel Mayr, Marc Lynch, Marika Fava, Marjan Jahangiri, Metzler, Michael T. Watkins, Rahmi Oklu, Sanjay Misra, Temo Barwari, Xiaoke Yin, Xu   +17 more
core   +3 more sources

The astacin family of metalloendopeptidases.

Journal of Biological Chemistry, 1991
Molecular cloning of a human intestinal brush border metalloendopeptidase (N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase, PPH) and a mouse kidney brush border metalloendopeptidase (meprin A) has revealed 82% identity in the NH2-terminal amino acid sequences (198 residues) of the mature enzymes.
E, Dumermuth, E E, Sterchi, W P, Jiang, R L, Wolz, J S, Bond, A V, Flannery, R J, Beynon   +6 more
openaire   +2 more sources

Long-term neprilysin gene transfer is associated with reduced levels of intracellular Abeta and behavioral improvement in APP transgenic mice [PDF]

, 2008
Background Proteolytic degradation has emerged as a key pathway involved in controlling levels of the Alzheimer's disease (AD)-associated amyloid-β (Aβ) peptide in the brain.
Patrick Christina, Potkar Rewati, Adame Anthony, Crews Leslie, Rockenstein Edward, Marr Robert A, Spencer Brian, Gage Fred H, Verma Inder M, Masliah Eliezer   +9 more
core   +1 more source

Secretion of Metalloendopeptidase 24.15 (EC 3.4.24.15) [PDF]

DNA and Cell Biology, 1999
The metalloendopeptidase EP24.15 (EC3.4.24.15) is a neuropeptide-metabolizing enzyme present in neural and endocrine tissues, presumably functioning extracellularly. Because the majority of the EP24.15 activity is identified in the soluble fraction of cellular homogenates, suggesting that the enzyme is primarily an intracellular protein, we addressed ...
Ferro, E. S., Tullai, J. W., Glucksman, M. J., Roberts, J. L.   +3 more
openaire   +3 more sources