Results 21 to 30 of about 3,395 (135)

Canonical and non‐canonical functions of proteins regulating mitochondrial dynamics in mammalian physiology

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney, Vincent Marcangeli, Krystel Desjardins, Shima Taherkhani, Gilles Gouspillou   +4 more
wiley   +1 more source

A Circuit of Mechanically Regulated Transcription Factors Balances Regenerative and Fibrotic Memory of Mesenchymal Stromal Cells

Advanced Science, Volume 13, Issue 37, 3 July 2026.
Producing MSCs on rigid culture substrates induces a scar‐making phenotype, jeapordizing therapeutic success. ‘Tissue‐soft’ surfaces prevent MSC fibrogenesis and preserve regenerative traits. An epigenetic network, driven by HOXA11 and SALL1, maintains ‘soft memory’ by keeping chromatin open in relaxed MSCs, promoting anti‐fibrotic programs.
Fereshteh Sadat Younesi, Andrew E. Miller, Li Diao, Xinying Guo, Natalie Andonian, Elham Karimizadeh, Thomas H. Barker, Boris Hinz   +7 more
wiley   +1 more source

The Trichinella Super‐Pangenome Reveals the Evolution of Encapsulation and Predicted Host–Parasite Protein Interactions

Advanced Science, Volume 13, Issue 37, 3 July 2026.
ABSTRACT The muscle capsule of Trichinella is a critical structure that impedes immune attacks and drug penetration, yet the molecular mechanisms underlying its formation remain poorly understood. Using a high‐quality super‐pangenome comprising 12 Trichinella species, we compared extensive genomic variations between encapsulating and non‐encapsulating ...
Qingbo Lv, Yi Liu, Ning Xu, Xiao Zhang, Yaming Yang, Chengyao Li, Hanhai Mao, Mingyuan Liu, Xiaolei Liu   +8 more
wiley   +1 more source

Safety evaluation of an extension of use of the food enzyme bacillolysin from the non‐genetically modified Bacillus amyloliquefaciens strain HPN 131

EFSA Journal, Volume 24, Issue 7, July 2026.
Abstract The food enzyme bacillolysin (bacillus metalloendopeptidase, EC 3.4.24.28) is produced with the non‐genetically modified Bacillus amyloliquefaciens strain HPN 131 by Kerry Ingredients & Flavours Ltd. The safety of this food enzyme was evaluated previously and it did not give rise to safety concerns when used in seven food manufacturing ...
EFSA Panel on Food Enzymes (FEZ), Holger Zorn, José Manuel Barat Baviera, Claudia Bolognesi, Francesco Catania, Gabriele Gadermaier, Ralf Greiner, Baltasar Mayo, Alicja Mortensen, Yrjö Henrik Roos, Marize L. M. Solano, Henk Van Loveren, Laurence Vernis, Daniele Cavanna, Valentina Tokić, Yi Liu   +15 more
wiley   +1 more source

Genome‐Wide In Silico Analysis of the Type VI Secretion System (T6SS) Within the Morganella Genus

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
▪ Species‐specific T6SS patterns among Morganella genus (M. morganii and M. sibonii). ▪ Only one‐third of M. morganii isolates haboured a T6SS. ▪ All M. sibonii possess four T6SS clusters. ▪ M. sibonii exhibited a wide diversity of effectors compared to M. morganii.
Mathilde Duque, Aymeric Jacquemin, Delphine Girlich, Rémy A. Bonnin, Laurent Dortet   +4 more
wiley   +1 more source

Safety evaluation of the food enzyme bacillolysin from the non‐genetically modified Bacillus amyloliquefaciens strain BP

EFSA Journal, Volume 24, Issue 6, June 2026.
Abstract The food enzyme bacillolysin (EC 3.4.24.28) is produced with the non‐genetically modified Bacillus amyloliquefaciens strain BP by HBI Enzymes Inc. The food enzyme is intended to be used in eight food manufacturing processes. Since residual amounts of total organic solids (TOS) are removed in one process, dietary exposure was calculated for the
EFSA Panel on Food Enzymes (FEZ), Holger Zorn, José Manuel Barat Baviera, Claudia Bolognesi, Francesco Catania, Gabriele Gadermaier, Ralf Greiner, Baltasar Mayo, Alicja Mortensen, Yrjö Henrik Roos, Marize L. M. Solano, Henk Van Loveren, Laurence Vernis, Simone Lunardi, Magdalena Andryszkiewicz, Daniele Cavanna, Ana Criado, Yi Liu   +17 more
wiley   +1 more source

The Cellular Response Capacity as Diagnostic Head Start in Neutrophil Endotoxemia Sensing

The FASEB Journal, Volume 40, Issue 10, 31 May 2026.
This study introduces the neutrophil cellular response capacity (CRC), a flow‐cytometry‐based approach for detecting prior endotoxin exposure across the inflammatory continuum in human whole blood. By comparing baseline and ex vivo restimulated neutrophil marker expression, the CRC identified low‐dose LPS exposure with greater analytical sensitivity ...
David Alexander Christian Messerer, Adam Omar Khalaf Mohamed, Lisa Wohlgemuth, Laura Vidoni, Christiane Leonie Knapp, Paul Müller, Bertram Dietrich Thomaß, Karl Föhr, Eberhard Barth, Manfred Weiss, Bettina Jungwirth, Kristina Nilsson Ekdahl, Bo Nilsson, Markus Huber‐Lang   +13 more
wiley   +1 more source

Serum Proteomic Analysis Using Gel‐Based Liquid Chromatography Tandem Mass Spectrometry Reveals Differences Between Canine Oral Malignancies and Non‐Malignant Conditions

Veterinary Medicine and Science, Volume 12, Issue 3, May 2026.
This study establishes a GeLC‐MS/MS‐based serum proteomics workflow for canine oral oncology to differentiate malignancies from non‐malignant conditions. Comprehensive protein profiling, pathway analysis and protein–drug interaction mapping reveal candidate biomarkers and insights into the pathogenesis of canine oral cancers.
Sekkarin Ploypetch, Sittiruk Roytrakul, Janthima Jaresitthikunchai, Narumon Phaonakrop, Gunnaporn Suriyaphol   +4 more
wiley   +1 more source

Associations of Neprilysin and Its Coding Gene Variation With Hypertension in Chinese Adults

The Journal of Clinical Hypertension, Volume 28, Issue 4, April 2026.
ABSTRACT Neprilysin (NEP) degrades several vasoactive peptides and may contribute to blood pressure maintenance. This study aims to examine the associations between serum NEP levels and variants at its coding gene and hypertension in a general Chinese population.
Junting Hu, Jing Duan, Jiexiang Jing, Qiu Zhang, Xianfeng Yu, Rongyan Zhang, Yuting Jia, Mingzhe Du, Penghao Wang, Xueyang Zhang, Yibing Jin, Xiangdong Yang, Mingzhi Zhang, Hao Peng, Yun Shen   +14 more
wiley   +1 more source

Safety evaluation of an extension of use of a food enzyme containing bacillolysin and subtilisin activities from the non‐genetically modified Bacillus amyloliquefaciens strain AR‐383

EFSA Journal, Volume 24, Issue 4, April 2026.
Abstract The food enzyme with two declared activities, bacillolysin (EC 3.4.24.28) and subtilisin (EC 3.4.21.62) is produced with the non‐genetically modified Bacillus amyloliquefaciens strain AR‐383 by AB Enzymes GmbH. The safety of this food enzyme was evaluated previously and it did not give rise to safety concerns when used in nine food ...
EFSA Panel on Food Enzymes (FEZ), Holger Zorn, José Manuel Barat Baviera, Claudia Bolognesi, Francesco Catania, Gabriele Gadermaier, Ralf Greiner, Baltasar Mayo, Alicja Mortensen, Yrjö Henrik Roos, Marize L. M. Solano, Henk Van Loveren, Laurence Vernis, Valentina Tokić, Daniele Cavanna, Yi Liu   +15 more
wiley   +1 more source