Results 41 to 50 of about 4,257 (183)

Associations of Neprilysin and Its Coding Gene Variation With Hypertension in Chinese Adults

The Journal of Clinical Hypertension, Volume 28, Issue 4, April 2026.
ABSTRACT Neprilysin (NEP) degrades several vasoactive peptides and may contribute to blood pressure maintenance. This study aims to examine the associations between serum NEP levels and variants at its coding gene and hypertension in a general Chinese population.
Junting Hu, Jing Duan, Jiexiang Jing, Qiu Zhang, Xianfeng Yu, Rongyan Zhang, Yuting Jia, Mingzhe Du, Penghao Wang, Xueyang Zhang, Yibing Jin, Xiangdong Yang, Mingzhi Zhang, Hao Peng, Yun Shen   +14 more
wiley   +1 more source

Safety evaluation of an extension of use of a food enzyme containing bacillolysin and subtilisin activities from the non‐genetically modified Bacillus amyloliquefaciens strain AR‐383

EFSA Journal, Volume 24, Issue 4, April 2026.
Abstract The food enzyme with two declared activities, bacillolysin (EC 3.4.24.28) and subtilisin (EC 3.4.21.62) is produced with the non‐genetically modified Bacillus amyloliquefaciens strain AR‐383 by AB Enzymes GmbH. The safety of this food enzyme was evaluated previously and it did not give rise to safety concerns when used in nine food ...
EFSA Panel on Food Enzymes (FEZ), Holger Zorn, José Manuel Barat Baviera, Claudia Bolognesi, Francesco Catania, Gabriele Gadermaier, Ralf Greiner, Baltasar Mayo, Alicja Mortensen, Yrjö Henrik Roos, Marize L. M. Solano, Henk Van Loveren, Laurence Vernis, Valentina Tokić, Daniele Cavanna, Yi Liu   +15 more
wiley   +1 more source

Genes for extracellular matrix-degrading metalloproteinases and their inhibitor, TIMP, are expressed during early mammalian development [PDF]

, 1989
Extracellular matrix (ECM) remodeling accompanies cell migration, cell-cell interactions, embryo expansion, uterine implantation, and tissue invasion during mammalian embryogenesis.
Adler, R. R., Brenner, C. A., Pedersen, R. A., Rappolee, D. A., Werb, Z   +4 more
core   +2 more sources

The Genetic Basis of Color Polymorphism in the Orb‐Web Spider Gasteracantha cancriformis

Ecology and Evolution, Volume 16, Issue 3, March 2026.
This study investigates the genetic basis of coloration in the polymorphic spider Gasteracantha cancriformis using RNA‐seq data from different female color morphs. We assembled a reference transcriptome and identified differentially expressed genes associated with known pigmentation pathways, including carotenoids, melanin, ommochromes, and pteridines.
Paula Torres‐Quintero, Carolina Pardo‐Díaz, Fabian Salgado‐Roa, Camilo Salazar   +3 more
wiley   +1 more source

Transcriptional profiles of Burkholderia pseudomallei reveal the direct and indirect roles of Sigma E under oxidative stress conditions [PDF]

, 2016
This is the final version of the article. Available from BioMed Central via the DOI in this record.BACKGROUND: Burkholderia pseudomallei, the causative agent of melioidosis, is a Gram-negative bacterium widely distributed in soil and water in endemic ...
Hemsley, CM, Jitprasutwit, S, Juntawieng, N, Korbsrisate, S, Ong, C, Ooi, WF, Tan, P, Titball, RW, Vattanaviboon, P   +8 more
core   +1 more source

Honokiol and Magnolol Exert an Anti‐Inflammatory Effect by Inhibiting JAK2/STAT3/IL17 Signalling in a Rat Model of Ulcerative Colitis: A Combination of Bioinformatics and Experimental Study

Journal of Cellular and Molecular Medicine, Volume 30, Issue 6, March 2026.
ABSTRACT Ulcerative colitis (UC) is a chronic, inflammatory bowel disease with limited clinical treatment. Traditional Chinese medicinal ingredients honokiol and magnolol have potential anti‐inflammatory and gastrointestinal protective effects. However, their anti‐inflammatory potential has not been investigated in UC.
Zhaoxu Cai, Shaojun Lu, Jingan Chen, Xiaoshan Yang, Junlin Lu, Changwen Feng   +5 more
wiley   +1 more source

Metzincin's canonical methionine is responsible for the structural integrity of the zinc-binding site [PDF]

, 2017
The metzincins constitute a subclan of metalloproteases possessing a HEXXHXXGXXH/D zinc-binding consensus sequence where the three histidines are zinc ligands and the glutamic acid is the catalytic base.
Baumann, Ulrich, Bumann, Mario, Hege, Thomas, Oberholzer, Anselm E., Russo, Santina   +4 more
core  

Microbial gene abundance and expression patterns across a river to ocean salinity gradient [PDF]

, 2015
© The Author(s), 2015. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in PLoS One 10 (2015): e0140578, doi: 10.1371/journal.pone.0140578.Microbial communities mediate the ...
Crump, Byron C., Fortunato, Caroline S.
core   +3 more sources

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, Volume 20, Issue 2, Page 331-347, February 2026.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Mep72, a metzincin protease that is preferentially secreted by biofilms of Pseudomonas aeruginosa. [PDF]

, 2014
In this work, we compared the profile of proteins secreted by planktonic and biofilm cultures of Pseudomonas aeruginosa using two-dimensional difference gel electrophoresis (2D-DiGE).
Bowden, Steven D, Chung, Jade CS, Lilley, Kathryn S, Nishikawa, Kahoko, Passmore, Ian J, Welch, Martin   +5 more
core   +7 more sources