Natural Inhibitors of Snake Venom Metalloendopeptidases: History and Current Challenges
Toxins, 2016 The research on natural snake venom metalloendopeptidase inhibitors (SVMPIs) began in the 18th century with the pioneering work of Fontana on the resistance that vipers exhibited to their own venom.
Viviane A. Bastos +4 more
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Arabidopsis Salicylic Acid-Binding Metalloendopeptidases TOP1 and TOP2 Regulate H2O2 Accumulation and Programmed Cell Death during the Immune Response against the Bacterial Pathogen Pseudomonas syringae [PDF]
, 2013 Salicylic acid is a phytohormone indispensable for plant immunity. Interactions between hosts and pathogens create selective pressures—a cycle whereby hosts evolve novel defenses and alarm systems while their pathogen counterparts evolve enhanced ...
Zampogna, Giulio
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Identification and bioinformatic analysis of neprilysin and neprilysin-like metalloendopeptidases in Drosophila melanogaster. [PDF]
, 2021 The neprilysin (M13) family of metalloendopeptidases comprises highly conserved ectoenzymes that cleave and thereby inactivate many physiologically relevant peptides in the extracellular space.
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gone early, a novel germline factor, ensures the proper size of the stem cell precursor pool in the Drosophila ovary. [PDF]
PLoS ONE, 2014 In order to sustain lifelong production of gametes, many animals have evolved a stem cell-based gametogenic program. In the Drosophila ovary, germline stem cells (GSCs) arise from a pool of primordial germ cells (PGCs) that remain undifferentiated even ...
Shinya Matsuoka +4 more
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, 2021 Marker conservative sequences of astacin-like metalloendopeptidases: The extended motif of the active site and Met turn.
Kuiming Wang (11681760) +7 more
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Diagnostics, 2018 Campylobacters are major enteropathogens worldwide with a substantial financial burden. Matrix metalloproteinases (MMPs) are proteolytic metalloendopeptidases with ability to modify immune response and shown to be upregulated in patients with several ...
Anna Nilsson +5 more
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Journal of Genetic Engineering and Biotechnology, 2019 Background Serratiopeptidase is an alkaline metalloendopeptidase, which acquired wide significance because of its therapeutic applications.
Swathi Nageswara +2 more
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Frontiers in Ecology and Evolution, 2019 Pholcid spiders (Araneae: Pholcidae), officially “cellar spiders” but popularly known as “daddy long-legs,” are renown for the potential of deadly toxic venom, even though venom composition and potency has never formally been studied.
Pamela A. Zobel-Thropp +6 more
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Hemodynamic regulation of metalloendopeptidases EC3.4; 24.15 and EC3.4; 24.16: expression and function in the vascular endothelium [PDF]
, 2005 Hemodynamic forces, namely shear stress and cyclic strain, have been well characterised as modulators of vascular endothelial function, and have been assigned an important role in the maintainence of vascular tone, haemostasis, and regulation of vascular
Cotter, Eoin J.
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Secretion of Metalloendopeptidase 24.15 (EC 3.4.24.15) [PDF]
DNA and Cell Biology, 1999 The metalloendopeptidase EP24.15 (EC3.4.24.15) is a neuropeptide-metabolizing enzyme present in neural and endocrine tissues, presumably functioning extracellularly. Because the majority of the EP24.15 activity is identified in the soluble fraction of cellular homogenates, suggesting that the enzyme is primarily an intracellular protein, we addressed ...
Ferro, E. S. +3 more
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