Results 11 to 20 of about 39 (39)

The Genetic Basis of Color Polymorphism in the Orb‐Web Spider Gasteracantha cancriformis

open access: yesEcology and Evolution, Volume 16, Issue 3, March 2026.
This study investigates the genetic basis of coloration in the polymorphic spider Gasteracantha cancriformis using RNA‐seq data from different female color morphs. We assembled a reference transcriptome and identified differentially expressed genes associated with known pigmentation pathways, including carotenoids, melanin, ommochromes, and pteridines.
Paula Torres‐Quintero   +3 more
wiley   +1 more source

Honokiol and Magnolol Exert an Anti‐Inflammatory Effect by Inhibiting JAK2/STAT3/IL17 Signalling in a Rat Model of Ulcerative Colitis: A Combination of Bioinformatics and Experimental Study

open access: yesJournal of Cellular and Molecular Medicine, Volume 30, Issue 6, March 2026.
ABSTRACT Ulcerative colitis (UC) is a chronic, inflammatory bowel disease with limited clinical treatment. Traditional Chinese medicinal ingredients honokiol and magnolol have potential anti‐inflammatory and gastrointestinal protective effects. However, their anti‐inflammatory potential has not been investigated in UC.
Zhaoxu Cai   +5 more
wiley   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

open access: yesMolecular Oncology, Volume 20, Issue 2, Page 331-347, February 2026.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian   +10 more
wiley   +1 more source

Engineering Adaptive Immunity in 3D: A Patient‐Specific Lymphoid Model Using Stromal Networks and Peripheral Blood Mononuclear Cells

open access: yesAdvanced Science, Volume 13, Issue 12, 27 February 2026.
This study presents a 3D lymphoid tissue model engineered from adipose‐derived stem cells differentiated into fibroblastic reticular cell–like networks and co‐cultured with immune cells. The engineered system successfully generates antigen‐specific antibodies and cytokine responses, providing a platform for studying adaptive immunity, vaccine efficacy,
Mei ElGindi, Shaza Karaman, Jeremy Teo
wiley   +1 more source

The Secretome of Human Trophoblast Stem Cells Attenuates Senescence‐Associated Traits

open access: yesAging Cell, Volume 25, Issue 2, February 2026.
Human trophoblast stem cell‐derived secretome/conditioned medium (hTSC‐CM) and the extracellular vesicles (EVs) therein suppress DNA damage and NF‐κB activation in senescent fibroblasts, in turn reducing the production of senescence‐associated secretory phenotype (SASP) factors. This study highlights hTSC‐CM and EVs as potential senotherapeutic agents.
Kotb Abdelmohsen   +18 more
wiley   +1 more source

Secretome Profiling of Young Multipotent Stem Cells Reveals Angiogenic and Immunomodulatory Mechanisms Supporting Aged Neuromuscular Health

open access: yesAging Cell, Volume 25, Issue 2, February 2026.
Young multipotent muscle‐derived stem/progenitor cells (MDSPCs) secrete a unique profile of pro‐angiogenic and immunomodulatory proteins that are diminished with age. Systemic transplantation of young MDSPCs into naturally aged mice activates pathways in neuromuscular tissues, enhancing health and driving molecular, structural, and functional ...
Seth D. Thompson   +5 more
wiley   +1 more source

Echinacoside Improves Pulmonary Vascular Remodeling by Regulating the L‐ and T‐Type Ca2+ Channels in the Prevention and Treatment of Pulmonary Hypertension

open access: yesPulmonary Circulation, Volume 16, Issue 1, January 2026.
ABSTRACT The typical pathology of pulmonary hypertension (PH) is characterized by pulmonary vasoconstriction and irreversible pulmonary vascular remodeling. Vascular remodeling is the process of structural changes and cellular rearrangement of blood vessels due to injury and is a significant factor in conditions such as PH.
Yuefu Zhao   +10 more
wiley   +1 more source

Genomic Connectivity and Adaptation Signals of the Freshwater Sponge Ephydatia muelleri Across Its Distribution

open access: yesJournal of Biogeography, Volume 53, Issue 1, January 2026.
ABSTRACT Aim Genetic connectivity and local adaptation were examined across the distribution of the freshwater sponge Ephydatia muelleri. Because it occupies an exceptional breadth of freshwater environments across a broad geographic range, this species offers key insights into biogeographic processes shaping genetic structure and adaptation in inland ...
Laura de la Cruz‐Castillejo   +18 more
wiley   +1 more source

Multiomics Reveals the Molecular Mechanism of Collagen Synthesis by Hydrolyzed Collagen Supplementation of Large Yellow Croaker (Larimichthys crocea)

open access: yesAquaculture Nutrition, Volume 2026, Issue 1, 2026.
This study investigated the effects of dietary hydrolyzed collagen supplementation on muscle quality and its underlying molecular mechanisms in large yellow croaker (Larimichthys crocea) (initial weight: 332.27 ± 3.79 g) over a 128‐day feeding trial.
Fangle Tong   +7 more
wiley   +1 more source
Some of the next articles are maybe not open access.

The astacin family of metalloendopeptidases

Protein Science, 1995
Judith S Bond, Robert J Beynon, J S Bond
exaly  

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