Results 11 to 20 of about 3,395 (135)

gone early, a novel germline factor, ensures the proper size of the stem cell precursor pool in the Drosophila ovary. [PDF]

PLoS ONE, 2014
In order to sustain lifelong production of gametes, many animals have evolved a stem cell-based gametogenic program. In the Drosophila ovary, germline stem cells (GSCs) arise from a pool of primordial germ cells (PGCs) that remain undifferentiated even ...
Shinya Matsuoka, Swati Gupta, Emiko Suzuki, Yasushi Hiromi, Miho Asaoka   +4 more
doaj   +1 more source

Safety evaluation of the food enzyme containing metalloendopeptidase and leucyl aminopeptidase activities from the non-genetically modified <i>Aspergillus oryzae</i> strain HBI-POP01. [PDF]

EFSA J
Abstract The food enzyme containing metalloendopeptidase (EC 3.4.24) and leucyl aminopeptidase (EC 3.4.11.1) activities is produced with the non‐genetically modified Aspergillus oryzae strain HBI‐POP01 by HBI Enzymes Inc. The food enzyme was considered free from viable cells of the production organism.
EFSA Panel on Food Enzymes (FEZ), Zorn H, Barat Baviera JM, Bolognesi C, Catania F, Gadermaier G, Greiner R, Mayo B, Mortensen A, Roos YH, Solano MLM, Van Loveren H, Vernis L, Criado A, Aguilera J, Andryszkiewicz M, Cavanna D, Fernández-Fraguas C, di Piazza G, Liu Y.   +19 more
europepmc   +2 more sources

Natural Inhibitors of Snake Venom Metalloendopeptidases: History and Current Challenges

Toxins, 2016
The research on natural snake venom metalloendopeptidase inhibitors (SVMPIs) began in the 18th century with the pioneering work of Fontana on the resistance that vipers exhibited to their own venom.
Viviane A. Bastos, Francisco Gomes-Neto, Jonas Perales, Ana Gisele C. Neves-Ferreira, Richard H. Valente   +4 more
doaj   +1 more source

Enhanced Systemic Response of Matrix Metalloproteinases and Their Regulators in Campylobacter and Salmonella Patients

Diagnostics, 2018
Campylobacters are major enteropathogens worldwide with a substantial financial burden. Matrix metalloproteinases (MMPs) are proteolytic metalloendopeptidases with ability to modify immune response and shown to be upregulated in patients with several ...
Anna Nilsson, Taina Tervahartiala, David Lennebratt, Anders Lannergård, Timo Sorsa, Hilpi Rautelin   +5 more
doaj   +1 more source

Purification, characterization, and structural elucidation of serralysin-like alkaline metalloprotease from a novel source

Journal of Genetic Engineering and Biotechnology, 2019
Background Serratiopeptidase is an alkaline metalloendopeptidase, which acquired wide significance because of its therapeutic applications.
Swathi Nageswara, Girijasankar Guntuku, Bhagya Lakshmi Yakkali   +2 more
doaj   +1 more source

Not so Dangerous After All? Venom Composition and Potency of the Pholcid (Daddy Long-Leg) Spider Physocyclus mexicanus

Frontiers in Ecology and Evolution, 2019
Pholcid spiders (Araneae: Pholcidae), officially “cellar spiders” but popularly known as “daddy long-legs,” are renown for the potential of deadly toxic venom, even though venom composition and potency has never formally been studied.
Pamela A. Zobel-Thropp, Jennifer Mullins, Charles Kristensen, Brent A. Kronmiller, Cynthia L. David, Linda A. Breci, Greta J. Binford   +6 more
doaj   +1 more source

Purification of Advanced Therapeutics by Flow‐Through Pseudo‐Affinity Chromatography: Bi‐Specific mABs, Fc Fusion Proteins, and Adeno‐Associated Viruses

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Modern biopharmaceutical manufacturing requires purification platforms capable of processing structurally and functionally diverse products while addressing the challenge of removing persistent and high‐risk host cell proteins (HCPs).
Wenning Chu, Eduardo Barbieri, Arianna Minzoni, Shriarjun Shastry, Jacob P. LeBarre, Qingbo Shu, Taufika Williams, Xuanwen Li, Divya Chandra, Xuankuo Xu, Jerome Bill, David Roush, Joseph Taris, Patrick Gilbert, Andre Kiesewetter, Oliver Rammo, Michael Schulte, Christopher Major, Trina Mouchahoir, Steven Cramer, Cristiana Boi, Ruben G. Carbonell, Abraham Lenhoff, Stefano Menegatti   +23 more
wiley   +1 more source

Secretion of Metalloendopeptidase 24.15 (EC 3.4.24.15) [PDF]

DNA and Cell Biology, 1999
The metalloendopeptidase EP24.15 (EC3.4.24.15) is a neuropeptide-metabolizing enzyme present in neural and endocrine tissues, presumably functioning extracellularly. Because the majority of the EP24.15 activity is identified in the soluble fraction of cellular homogenates, suggesting that the enzyme is primarily an intracellular protein, we addressed ...
Ferro, E. S., Tullai, J. W., Glucksman, M. J., Roberts, J. L.   +3 more
openaire   +3 more sources

From biology to biotechnology: Host‐regulation factors from parasitoid wasps are a source of bioactive molecules with translational potential

Insect Molecular Biology, EarlyView.
Parasitoid wasps deploy maternal and embryonic factors to reprogramme host physiology. Venom, calyx fluid, polydnaviruses, teratocytes and larval secretions act in a coordinated, compartmentalised manner. Host‐regulation factors are promising sources of insecticidal, antimicrobial and bioinspired translational molecules.
Ciro Pedro G. Pinto, Andrew A. Walker, Glenn F. King   +2 more
wiley   +1 more source

Phage-based decontamination: Exploring resistance, disinfectant tolerance, and virulence trade-offs in Acinetobacter baumannii

Ecotoxicology and Environmental Safety
Increasing multidrug resistance in Acinetobacter baumannii necessitates a better understanding of how phage resistance influences bacterial fitness, disinfectant tolerance, and virulence.
Yi-Ting Chen, Li-Kuang Chen, Ruei-Sen Jiang, Kai-Chih Chang, Chun-Chieh Tseng   +4 more
doaj   +1 more source