The Rebirth of Matrix Metalloproteinase Inhibitors: Moving Beyond the Dogma [PDF]
Cells, 2019 The pursuit of matrix metalloproteinase (MMP) inhibitors began in earnest over three decades ago. Initial clinical trials were disappointing, resulting in a negative view of MMPs as therapeutic targets.
Gregg B. Fields
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Matrix metalloproteinase inhibitors enhance the efficacy of frontline drugs against Mycobacterium tuberculosis. [PDF]
PLoS Pathogens, 2018 Mycobacterium tuberculosis (Mtb) remains a grave threat to world health with emerging drug resistant strains. One prominent feature of Mtb infection is the extensive reprogramming of host tissue at the site of infection. Here we report that inhibition of
Yitian Xu +12 more
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Integrin α2β1 Expression Regulates Matrix Metalloproteinase-1-Dependent Bronchial Epithelial Repair in Pulmonary Tuberculosis [PDF]
Frontiers in Immunology, 2018 Pulmonary tuberculosis (TB) is caused by inhalation of Mycobacterium tuberculosis, which damages the bronchial epithelial barrier to establish local infection.
Sara Brilha +8 more
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Bone-Seeking Matrix Metalloproteinase Inhibitors for the Treatment of Skeletal Malignancy [PDF]
Pharmaceuticals, 2020 Matrix metalloproteinases (MMPs) are a family of enzymes involved at different stages of cancer progression and metastasis. We previously identified a novel class of bisphosphonic inhibitors, selective for MMPs crucial for bone remodeling, such as MMP-2.
Antonio Laghezza +11 more
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Molecular Imaging Probes Based on Matrix Metalloproteinase Inhibitors (MMPIs) [PDF]
Molecules, 2019 Matrix metalloproteinases (MMPs) are a family of zinc- and calcium-dependent endopeptidases which are secreted or anchored in the cell membrane and are capable of degrading the multiple components of the extracellular matrix (ECM).
Loganathan Rangasamy +6 more
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Discovery and Characterisation of Novel Poly-Histidine-Poly-Glycine Peptides as Matrix Metalloproteinase Inhibitors [PDF]
BiomoleculesFor the first time, two poly-histidine-poly-glycine peptides (pHpG-H5 and pHpG-H7) were identified as promising candidates for matrix metalloproteinase inhibitors. cDNAs encoding pHpG-H5 and pHpG-H7 peptides were isolated from the Atheris squamigera cDNA
He Wang +8 more
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Matrix Metalloproteinase Inhibitors and Their Potential Clinical Application in Periodontitis [PDF]
DiseasesMatrix metalloproteinases (MMPs) are a family of endopeptidases recognized for their involvement in the degradation of the extracellular matrix and their important role in the pathogenesis of periodontitis.
Daniela Mendoza-Juárez +5 more
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MMpI: A WideRange of Available Compounds of Matrix Metalloproteinase Inhibitors. [PDF]
PLoS ONE, 2016 Matrix metalloproteinases (MMPs) are a family of zinc-dependent proteinases involved in the regulation of the extracellular signaling and structural matrix environment of cells and tissues.
Charuvaka Muvva +2 more
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Matrix metalloproteinase inhibitors in restorative dentistry. [PDF]
J Conserv Dent EndodAbstract Matrix metalloproteinases (MMPs) have been identified as agents that disintegrate the collagen structures of dental hybrid layers, resulting in reduced restorative bond strength. Multiple MMP inhibitors (MMPIs) are known to counteract this degenerative mechanism, thereby preserving bond strength and promoting the longevity of resin ...
Perarivalan I +4 more
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Matrix Metalloproteinase Inhibitors in Cancer Therapy: Turning Past Failures Into Future Successes. [PDF]
Mol Cancer Ther, 2018 Winer A, Adams S, Mignatti P.
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