Results 11 to 20 of about 244,384 (286)
Matrix metalloproteinase-9 (MMP-9) and its inhibitors in cancer: A minireview
European Journal of Medicinal Chemistry, 2020 Matrix metalloproteinases (MMPs) are zinc dependent proteolytic metalloenzyme. MMP-9 is one of the most complex forms of matrix metalloproteinases. MMP-9 has the ability to degrade the extracellular matrix (ECM) components and has important role in the ...
, Tarun Jha, Sk Abdul Amin
exaly +2 more sources
Marine Drugs, 2009 Matrix metalloproteinases (MMPs) are a family of more than twenty five secreted and membrane-bound zinc-endopeptidases which can degrade extracellular matrix (ECM) components.
Se-Kwon Kim, Kim Se-Kwon
exaly +2 more sources
Metalloproteinases in Medicine, 2016 : The development of therapeutic matrix metalloproteinase (MMP) inhibitors has evolved from broad-spectrum peptidomimetic inhibitors with deleterious side effects, to highly selective agents.
Irit Sagi, Niv Papo
exaly +2 more sources
In-silico identification and optimization of MMP-9 inhibitors for cerebral ischemia using structure based virtual screening, MD simulation, and binding free energy calculations. [PDF]
PLoS ONECerebral ischemia is a leading cause of disability and mortality due to the limited therapies of neuroprotection. Matrix metalloproteinase-9 (MMP-9) plays a major role in cerebral ischemia as it breaks down the components of extracellular matrix, which ...
Jian Zhang +3 more
doaj +2 more sources
ELECTRON WITHDRAWING GROUP EFFECT ON BIOLOGICAL ACTIVITIES OF PYRIMIDINE HYBRIDS AS POTENTIAL ANTI-MATRIX METALLOPROTEINASE-7 [PDF]
Química Nova, 2023 We investigated the effect of both electron donating group and e//lectron withdrawing group on biological activity of pyrimidine-based compounds as metalloproteinase-7 inhibitors and predicting a library of drug-like compounds with potent cytotoxicity ...
Abel Kolawole Oyebamiji +7 more
doaj +1 more source
Matrix metalloproteinases and their inhibitors
Фармакокинетика и Фармакодинамика, 2019 Metalloproteinase was discovered by Gross and Lapierre in 1962 for the first time. Since then, more than 20 enzymes of this family have been characterized, and their functions have been studied in detail.
O. S. Grigorkevich +2 more
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Бюллетень сибирской медицины, 2022 Aim. To study the content of matrix metalloproteinase (MMP)-2, -3, -9 and tissue inhibitors of metalloproteinases (TIMPs) -1, -2, -3, -4 in the aqueous humor of patients with moderate primary open-angle glaucoma (POAG).Materials and methods.
V. V. Chernykh +4 more
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Journal of Orofacial Sciences, 2014 Objectives: The study aims to explore the expression of the matrix metalloproteinases (MMP-2, -9) and their inhibitors (tissue inhibitors of metalloproteinase [TIMP]-1, -2) as well as the correlation between them in the different morphological forms of ...
Natheer Hashim Al-Rawi +2 more
doaj +1 more source
Physiological Reports, 2020 Pelvic organ prolapse (POP) decreases quality of life for many women, but its pathophysiology is poorly understood. We have previously shown that Lysyl oxidase‐like 1 knockout (Loxl1 KO) mice reliably prolapse with age and increased parity, similar to ...
Slater A. Jameson +8 more
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Development of Matrix Metalloproteinase-2 Inhibitors for Cardioprotection
Frontiers in Pharmacology, 2018 The objective of our present study is to develop novel inhibitors for MMP-2 for acute cardioprotection. In a series of pilot studies, novel substituted carboxylic acid derivatives were synthesized based on imidazole and thiazole scaffolds and then tested
Péter Bencsik +23 more
doaj +1 more source