Results 11 to 20 of about 73,119 (252)

The regulation of matrix metalloproteinases and their inhibitors [PDF]

The International Journal of Biochemistry & Cell Biology, 2008
The matrix metalloproteinases (MMP) are a family of 23 enzymes in man. These enzymes were originally described as cleaving extracellular matrix (ECM) substrates with a predominant role in ECM homeostasis, but it is now clear that they have much wider functionality.
Clark, Ian M., Swingler, Tracey E., Sampieri, Clara L., Edwards, Dylan R.   +3 more
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The Pharmacological TAILS of Matrix Metalloproteinases and Their Inhibitors [PDF]

Pharmaceuticals, 2020
Matrix metalloproteinases (MMPs) have been demonstrated to have both detrimental and protective functions in inflammatory diseases. Several MMP inhibitors, with the exception of Periostat®, have failed in Phase III clinical trials. As an alternative strategy, recent efforts have been focussed on the development of more selective inhibitors or targeting
Nabangshu Das, Colette Benko, Sean E. Gill, Antoine Dufour   +3 more
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Clinical Investigation of Matrix Metalloproteinases, Tissue Inhibitors of Matrix Metalloproteinases, and Matrix Metalloproteinase/Tissue Inhibitors of Matrix Metalloproteinase Complexes and Their Networks in Apical Periodontitis [PDF]

Journal of Endodontics, 2016
This clinical study investigated the levels of metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) and respective forms (MMP/TIMP complexes) in apical periodontitis to determine their networks in the development of clinical/radiographic features, thus quantifying the levels of endotoxins (lipopolysaccharides) present in primarily infected ...
Frederico C. Martinho, Flávia F.C. Teixeira, Flávia G.R. Cardoso, Nádia S. Ferreira, Gustavo G. Nascimento, Cláudio A.T. Carvalho, Márcia C. Valera   +6 more
openaire   +3 more sources

Features of the level of matrix metalloproteinase-2, -3, -9 and tissue inhibitors of metalloproteinases-1, -2, -3, -4 in the aqueous humor of patients with primary open-angle glaucoma

Бюллетень сибирской медицины, 2022
Aim. To study the content of matrix metalloproteinase (MMP)-2, -3, -9 and tissue inhibitors of metalloproteinases (TIMPs) -1, -2, -3, -4 in the aqueous humor of patients with moderate primary open-angle glaucoma (POAG).Materials and methods.
V. V. Chernykh, V. I. Konenkov, O. V. Ermakova, N. B. Orlov, A. N. Trunov   +4 more
doaj   +1 more source

Expression of matrix metalloproteinase-2 and 9 with their inhibitors, tissue inhibitors of metalloproteinase-1 and 2 in oral lichen planus

Journal of Orofacial Sciences, 2014
Objectives: The study aims to explore the expression of the matrix metalloproteinases (MMP-2, -9) and their inhibitors (tissue inhibitors of metalloproteinase [TIMP]-1, -2) as well as the correlation between them in the different morphological forms of ...
Natheer Hashim Al-Rawi, Thaer Kassim Al-Kassam, Ahlam Hameed Majeed   +2 more
doaj   +1 more source

Elastin homeostasis is altered with pelvic organ prolapse in cultures of vaginal cells from a lysyl oxidase‐like 1 knockout mouse model

Physiological Reports, 2020
Pelvic organ prolapse (POP) decreases quality of life for many women, but its pathophysiology is poorly understood. We have previously shown that Lysyl oxidase‐like 1 knockout (Loxl1 KO) mice reliably prolapse with age and increased parity, similar to ...
Slater A. Jameson, Ganesh Swaminathan, Shataakshi Dahal, Bruna Couri, Mei Kuang, Anna Rietsch, Robert S. Butler, Anand Ramamurthi, Margot S. Damaser   +8 more
doaj   +1 more source

Development of Matrix Metalloproteinase-2 Inhibitors for Cardioprotection

Frontiers in Pharmacology, 2018
The objective of our present study is to develop novel inhibitors for MMP-2 for acute cardioprotection. In a series of pilot studies, novel substituted carboxylic acid derivatives were synthesized based on imidazole and thiazole scaffolds and then tested
Péter Bencsik, Péter Bencsik, Krisztina Kupai, Anikó Görbe, Anikó Görbe, Éva Kenyeres, Éva Kenyeres, Zoltán V. Varga, János Pálóczi, Renáta Gáspár, László Kovács, Lutz Weber, Ferenc Takács, István Hajdú, István Hajdú, Gabriella Fabó, Sándor Cseh, László Barna, László Barna, Tamás Csont, Csaba Csonka, György Dormán, Péter Ferdinandy, Péter Ferdinandy   +23 more
doaj   +1 more source

Matrix metalloproteinases and their inhibitors [PDF]

Acta Orthopaedica Scandinavica, 1995
The progressive breakdown of connective tissues of the articular joints is a major feature of the arthritides and becomes an irreversible process leading to permanent loss of function and disability. Recent research has been directed at the analysis of the relative roles of different cell types and the different classes of proteinases that they produce
openaire   +2 more sources

Extracellular matrix change in patients with various forms of atrial fibrillation

Journal of Education, Health and Sport, 2017
Purpose: We studied the change in serum collagen markers in patients with various forms of atrial fibrillation (AF) Methods: Collagen type C-terminal propeptide (CTPK-I), C-terminal telopeptide of type I collagen (CTTK-I), matrix metalloproteinase I ...
A. V. Goryachiy, A. I. Gozhenko, E. M. Levchenko, V. V. Goriachyi, M. A. Kuznetsova, M. I. Arapu   +5 more
doaj   +3 more sources

Integrin α2β1 Expression Regulates Matrix Metalloproteinase-1-Dependent Bronchial Epithelial Repair in Pulmonary Tuberculosis

Frontiers in Immunology, 2018
Pulmonary tuberculosis (TB) is caused by inhalation of Mycobacterium tuberculosis, which damages the bronchial epithelial barrier to establish local infection.
Sara Brilha, Sara Brilha, Deborah L. W. Chong, Akif A. Khawaja, Catherine W. M. Ong, Catherine W. M. Ong, Naomi J. Guppy, Joanna C. Porter, Jon S. Friedland   +8 more
doaj   +1 more source