Results 21 to 30 of about 244,384 (286)
Extracellular matrix change in patients with various forms of atrial fibrillation
Journal of Education, Health and Sport, 2017 Purpose: We studied the change in serum collagen markers in patients with various forms of atrial fibrillation (AF) Methods: Collagen type C-terminal propeptide (CTPK-I), C-terminal telopeptide of type I collagen (CTTK-I), matrix metalloproteinase I ...
A. V. Goryachiy +5 more
doaj +3 more sources
Frontiers in Immunology, 2018 Pulmonary tuberculosis (TB) is caused by inhalation of Mycobacterium tuberculosis, which damages the bronchial epithelial barrier to establish local infection.
Sara Brilha +8 more
doaj +1 more source
Protease Inhibitor-Dependent Inhibition of Light-Induced Stomatal Opening
Frontiers in Plant Science, 2021 Stomata in the epidermis of plants play essential roles in the regulation of photosynthesis and transpiration. Stomata open in response to blue light (BL) by phosphorylation-dependent activation of the plasma membrane (PM) H+-ATPase in guard cells. Under
Tenghua Wang +10 more
doaj +1 more source
The regulation of matrix metalloproteinases and their inhibitors [PDF]
The International Journal of Biochemistry & Cell Biology, 2008 The matrix metalloproteinases (MMP) are a family of 23 enzymes in man. These enzymes were originally described as cleaving extracellular matrix (ECM) substrates with a predominant role in ECM homeostasis, but it is now clear that they have much wider functionality.
Clark, Ian M. +3 more
openaire +3 more sources
Matrix metalloproteinases and their inhibitors [PDF]
Acta Orthopaedica Scandinavica, 1995 The progressive breakdown of connective tissues of the articular joints is a major feature of the arthritides and becomes an irreversible process leading to permanent loss of function and disability. Recent research has been directed at the analysis of the relative roles of different cell types and the different classes of proteinases that they produce
openaire +2 more sources
Design and Structural Evolution of Matrix Metalloproteinase Inhibitors.
Chemistry, 2019 Matrix metalloproteinases (MMPs) are involved in a multitude of severe diseases. Despite MMPs being considered druggable targets, past drug-discovery programs have not delivered the anticipated clinical benefits.
T. Fischer, Nicole Senn, Rainer Riedl
semanticscholar +1 more source
Peptide-Based Selective Inhibitors of Matrix Metalloproteinase-Mediated Activities
Molecules, 2012 The matrix metalloproteinases (MMPs) exhibit a broad array of activities, some catalytic and some non-catalytic in nature. An overall lack of selectivity has rendered small molecule, active site targeted MMP inhibitors problematic in execution ...
Margaret W. Ndinguri +4 more
doaj +1 more source
Do matrix metalloproteinase and cathepsin K inhibitors work synergistically to reduce dentin erosion? [PDF]
Journal of Applied Oral Science, 2023 Objectives To evaluate the effects of matrix metalloproteinase (MMP) and cathepsin K (catK) inhibitors on resistance to dentin erosion. Methodology A total of 96 dentin specimens (3×3×2 mm) were prepared and randomly assigned into four groups (n=24 ...
Xiujiao LIN +4 more
doaj +1 more source
Journal of Pharmacy and Bioallied Sciences, 2012 Matrix metalloproteinases (MMPs) form a group of more than 20 zinc-dependent enzymes that are crucial in the degradation of the main components in the extracellular matrix, and thereby play important roles in cell migration, wound healing, and tissue ...
Esther Nalini Honibald +4 more
doaj +1 more source
Metalloproteinases and Their Inhibitors: Potential for the Development of New Therapeutics
Cells, 2020 The metalloproteinase (MP) family of zinc-dependent proteases, including matrix metalloproteinases (MMPs), a disintegrin and metalloproteases (ADAMs), and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTSs) plays a crucial role in ...
Maryam Raeeszadeh-Sarmazdeh +2 more
doaj +1 more source