Results 21 to 30 of about 73,119 (252)

Protease Inhibitor-Dependent Inhibition of Light-Induced Stomatal Opening

Frontiers in Plant Science, 2021
Stomata in the epidermis of plants play essential roles in the regulation of photosynthesis and transpiration. Stomata open in response to blue light (BL) by phosphorylation-dependent activation of the plasma membrane (PM) H+-ATPase in guard cells. Under
Tenghua Wang, Tenghua Wang, Wenxiu Ye, Wenxiu Ye, Yin Wang, Yin Wang, Maoxing Zhang, Maoxing Zhang, Yusuke Aihara, Toshinori Kinoshita, Toshinori Kinoshita   +10 more
doaj   +1 more source

Perioceutics: Matrix metalloproteinase inhibitors as an adjunctive therapy for inflammatory periodontal disease

Journal of Pharmacy and Bioallied Sciences, 2012
Matrix metalloproteinases (MMPs) form a group of more than 20 zinc-dependent enzymes that are crucial in the degradation of the main components in the extracellular matrix, and thereby play important roles in cell migration, wound healing, and tissue ...
Esther Nalini Honibald, Sebeena Mathew, Jeyantha Padmanaban, Elanchezhiyan Sundaram, Renuka Devi Ramamoorthy   +4 more
doaj   +1 more source

Do matrix metalloproteinase and cathepsin K inhibitors work synergistically to reduce dentin erosion? [PDF]

Journal of Applied Oral Science, 2023
Objectives To evaluate the effects of matrix metalloproteinase (MMP) and cathepsin K (catK) inhibitors on resistance to dentin erosion. Methodology A total of 96 dentin specimens (3×3×2 mm) were prepared and randomly assigned into four groups (n=24 ...
Xiujiao LIN, Xinwen TONG, Hui YANG, Yiying CHEN, Hao YU   +4 more
doaj   +1 more source

Peptide-Based Selective Inhibitors of Matrix Metalloproteinase-Mediated Activities

Molecules, 2012
The matrix metalloproteinases (MMPs) exhibit a broad array of activities, some catalytic and some non-catalytic in nature. An overall lack of selectivity has rendered small molecule, active site targeted MMP inhibitors problematic in execution ...
Margaret W. Ndinguri, Manishabrata Bhowmick, Dorota Tokmina-Roszyk, Trista K. Robichaud, Gregg B. Fields   +4 more
doaj   +1 more source

Metalloproteinases and Their Inhibitors: Potential for the Development of New Therapeutics

Cells, 2020
The metalloproteinase (MP) family of zinc-dependent proteases, including matrix metalloproteinases (MMPs), a disintegrin and metalloproteases (ADAMs), and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTSs) plays a crucial role in ...
Maryam Raeeszadeh-Sarmazdeh, Linh D. Do, Brianne G. Hritz   +2 more
doaj   +1 more source

Genetic and morphological aspects of the enterocutaneous fistula development

Клінічна хірургія, 2020
Objective. To analyze the frequency of polymorphic variants of matrix metalloproteinase-2 (C-1306 → T) and tissue inhibitors of metalloproteinase-2 (G303 → A) genes in patients with enterocutaneous fistulas and to identify the connection with ...
Yu. Usenko, Ya. Yu. Voitiv
doaj   +1 more source

The possibilities of using the inhibitors of matrix metalloproteinases for keratoplasty

Трансплантология (Москва), 2023
Introduction. The review is devoted to the actual problem of treating patients with keratolysis. The role of matrix metalloproteinases in the pathogenesis of cornea and corneal graft melting is discussed as well as the practical experience of using ...
K. V. Sirotkina, E. V. Chentsova
doaj   +1 more source

The role of metalloproteinase and hypoxia conditions in endometrial cells and embryo implantation

Journal of Current Biomedical Reports, 2020
In the process of implantation, metalloproteinase enzymes play a key role in basement membrane degradation and endometrial extracellular matrix. The activity of these enzymes is impeded by binding Tissue Inhibitors of Metalloproteinase (TIMP). The oxygen
Maryam Mahdavi, Diba Bagheri, Elmira Vanaki, Mehdi Shamsara, Ehsan Hashemi, Saeed Ansari, Mojtaba Dashtizad, Morteza Daliri Joupari   +7 more
doaj   +1 more source

Investigation of the relationship between matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase with SARS CoV-2 infections

Journal of Advanced Biotechnology and Experimental Therapeutics, 2023
SARS-CoV-2 stands for severe acute respiratory syndrome coronavirus 2 which is the causative agent of spreading coronavirus disease 2019 that is known as COVID-19 pandemic, the disease leads to severe acute respiratory illness. Matrix metalloproteinases-
May K. Ismael, Lubna M. Rasuol, Yasir Basim Qaddoori   +2 more
doaj   +1 more source

Discovery of Sulfated Small Molecule Inhibitors of Matrix Metalloproteinase-8

Biomolecules, 2020
Elevated matrix metalloproteinase-8 (MMP-8) activity contributes to the etiology of many diseases, including atherosclerosis, pulmonary fibrosis, and sepsis. Yet, very few small molecule inhibitors of MMP-8 have been identified.
Shravan Morla, Umesh R. Desai
doaj   +1 more source