Results 31 to 40 of about 244,384 (286)

The Pharmacological TAILS of Matrix Metalloproteinases and Their Inhibitors [PDF]

Pharmaceuticals, 2020
Matrix metalloproteinases (MMPs) have been demonstrated to have both detrimental and protective functions in inflammatory diseases. Several MMP inhibitors, with the exception of Periostat®, have failed in Phase III clinical trials. As an alternative strategy, recent efforts have been focussed on the development of more selective inhibitors or targeting
Nabangshu Das, Colette Benko, Sean E. Gill, Antoine Dufour   +3 more
openaire   +3 more sources

Genetic and morphological aspects of the enterocutaneous fistula development

Клінічна хірургія, 2020
Objective. To analyze the frequency of polymorphic variants of matrix metalloproteinase-2 (C-1306 → T) and tissue inhibitors of metalloproteinase-2 (G303 → A) genes in patients with enterocutaneous fistulas and to identify the connection with ...
Yu. Usenko, Ya. Yu. Voitiv
doaj   +1 more source

The possibilities of using the inhibitors of matrix metalloproteinases for keratoplasty

Трансплантология (Москва), 2023
Introduction. The review is devoted to the actual problem of treating patients with keratolysis. The role of matrix metalloproteinases in the pathogenesis of cornea and corneal graft melting is discussed as well as the practical experience of using ...
K. V. Sirotkina, E. V. Chentsova
doaj   +1 more source

Investigation of the relationship between matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase with SARS CoV-2 infections

Journal of Advanced Biotechnology and Experimental Therapeutics, 2023
SARS-CoV-2 stands for severe acute respiratory syndrome coronavirus 2 which is the causative agent of spreading coronavirus disease 2019 that is known as COVID-19 pandemic, the disease leads to severe acute respiratory illness. Matrix metalloproteinases-
May K. Ismael, Lubna M. Rasuol, Yasir Basim Qaddoori   +2 more
doaj   +1 more source

Clinical Investigation of Matrix Metalloproteinases, Tissue Inhibitors of Matrix Metalloproteinases, and Matrix Metalloproteinase/Tissue Inhibitors of Matrix Metalloproteinase Complexes and Their Networks in Apical Periodontitis [PDF]

Journal of Endodontics, 2016
This clinical study investigated the levels of metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) and respective forms (MMP/TIMP complexes) in apical periodontitis to determine their networks in the development of clinical/radiographic features, thus quantifying the levels of endotoxins (lipopolysaccharides) present in primarily infected ...
Frederico C. Martinho, Flávia F.C. Teixeira, Flávia G.R. Cardoso, Nádia S. Ferreira, Gustavo G. Nascimento, Cláudio A.T. Carvalho, Márcia C. Valera   +6 more
openaire   +3 more sources

Discovery of Sulfated Small Molecule Inhibitors of Matrix Metalloproteinase-8

Biomolecules, 2020
Elevated matrix metalloproteinase-8 (MMP-8) activity contributes to the etiology of many diseases, including atherosclerosis, pulmonary fibrosis, and sepsis. Yet, very few small molecule inhibitors of MMP-8 have been identified.
Shravan Morla, Umesh R. Desai
doaj   +1 more source

The role of metalloproteinase and hypoxia conditions in endometrial cells and embryo implantation

Journal of Current Biomedical Reports, 2020
In the process of implantation, metalloproteinase enzymes play a key role in basement membrane degradation and endometrial extracellular matrix. The activity of these enzymes is impeded by binding Tissue Inhibitors of Metalloproteinase (TIMP). The oxygen
Maryam Mahdavi, Diba Bagheri, Elmira Vanaki, Mehdi Shamsara, Ehsan Hashemi, Saeed Ansari, Mojtaba Dashtizad, Morteza Daliri Joupari   +7 more
doaj   +1 more source

Effects of Topical Intranasal Doxycycline Treatment in the Rat Allergic Rhinitis Model [PDF]

Clinical and Experimental Otorhinolaryngology, 2014
ObjectivesAllergic rhinitis (AR) is a chronic upper respiratory tract disease that inflames the mucous membranes of the nose and occurs when circulating inflammatory cells including eosinophils and basophils migrate to and accumulate in the inflammation ...
Mehmet Ozgür Avincsal, Seda Ozbal, Ahmet Omer Ikiz, Cetin Pekcetin, Enis Alpin Güneri   +4 more
doaj   +1 more source

Salivary profile of matrix metalloproteinase-8, tissue inhibitors of matrix metalloproteinase-1, myeloperoxidase, and nitrous oxide in smokers versus nonsmokers with chronic periodontitis

Journal of International Clinical Dental Research Organization, 2021
Background: Smoking is the second strongest modifiable risk factor for periodontal disease. Tissue destruction might result from matrix metalloproteinase (MMP)/tissue inhibitors of MMP (TIMP) imbalance in the diseased tissues.
Deepti Gattani, Jigyasa Sahu, Nupur Kar, Ritika Gattani   +3 more
doaj   +1 more source

LPS Counter Regulates RNA Expression of Extracellular Proteases and Their Inhibitors in Murine Macrophages

Mediators of Inflammation, 2012
Besides their evident importance in host defense, macrophages have been shown to play a detrimental role in different pathological conditions, including chronic inflammation, atherosclerosis, and cancer.
Andreas Hald, Birgitte Rønø, Leif R. Lund, Kristoffer L. Egerod   +3 more
doaj   +1 more source