Role of Matrix Metalloproteinase-2 in Eosinophil-Mediated Airway Remodeling [PDF]
Frontiers in Immunology, 2018 Airway remodeling is responsible for the progressive decline of lung function in bronchial asthma. Matrix metalloproteinase-2 and fibroblast-to-myofibroblast transition are involved in tissue remodeling.
Yu Kuwabara +10 more
doaj +2 more sources
Protective Role of Matrix Metalloproteinase-2 in Allergic Bronchial Asthma [PDF]
Frontiers in Immunology, 2019 Inflammation, reversible obstruction, and hyperresponsiveness of the airways are characteristic findings of bronchial asthma. Several evidence has demonstrated the involvement of matrix metalloproteinase-2 in allergic airway inflammation.
Yoshinori Takahashi +17 more
doaj +3 more sources
Amelioration of Pulmonary Fibrosis by Matrix Metalloproteinase-2 Overexpression. [PDF]
Int J Mol Sci, 2023 三重大学博士(医学)application/pdfIdiopathic pulmonary fibrosis is a progressive and fatal disease with a poor prognosis.Matrix metalloproteinase-2 is involved in the pathogenesis of organ fibrosis.
Inoue R +13 more
europepmc +4 more sources
Modulation of autocrine TNF-α-stimulated matrix metalloproteinase 9 (MMP-9) expression by mitogenactivated protein kinases in THP-1 monocytic cells [PDF]
, 2006 Matrix metalloproteinase 9 (MMP-9) is implicated in various physiological processes by its ability to degrade the extracellular matrix (ECM) and process multiple regulatory proteins. Normally, MMP-9 expression is tightly controlled in cells. Sustained or
Helmut Kolb +9 more
core +1 more source
Matrix metalloproteinases at key junctions in the pathomechanism of stroke [PDF]
, 2011 Matrix metalloproteinases play a crucial role in the remodelling of the extracellular matrix through direct degradation of its structural proteins and control of extracellular signaling.
Kolev, Kraszimir +5 more
core +1 more source
Correlation of Matrix Metalloproteinases and Tissue Inhibitors of Matrix Metalloproteinase Expression in Ileal Carcinoids, Lymph Nodes and Liver Metastasis with Prognosis and Survival [PDF]
, 2009 Purpose: Ileal carcinoids are gut epithelial tumors originating from serotonin-containing enterochromaffin (EC) cells. Therapeutic options for effectively inhibiting the growth and spread of metastatic carcinoids are still limited.
Braun, Thomas +11 more
core +2 more sources
Biomedicines, 2023 Introduction: Urinary bladder cancer is a serious oncological problem that is the cause of many deaths worldwide. The processes of metastasis and origination of local tumor invasion depend on the extracellular matrix (ECM) degradation.
Jacek Kudelski +7 more
doaj +1 more source
Modulation of plasma matrix metalloproteinase 9 and its inhibitors by vitamin D. [PDF]
, 2012 PhDMatrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) are upregulated in a variety of diseases. Hypothesis: As TIMP-1 levels are elevated in liver fibrosis, might a similar process occur in essential hypertension driven left ...
Timms, Peter McLean
core +4 more sources
Contribution of Matrix Metalloproteinase-9 to Cerebral Edema and Functional Outcome following Experimental Subarachnoid Hemorrhage [PDF]
, 2011 Background: Cerebral edema is an important risk factor for death and poor outcome following subarachnoid hemorrhage (SAH). However, underlying mechanisms are still poorly understood.
Karsten Schöller +9 more
core +1 more source
Tumor Biology, 2017 The aim of this study was to correlate matrix metalloproteinase-2 and matrix metalloproteinase-9 expression with the clinicopathological features and outcome of patients with early gastric cancer and to clinically elucidate more information on the role ...
Zhihua Yao +11 more
doaj +1 more source