Matrix Metalloproteinase-9 (MMP-9) as a Cancer Biomarker and MMP-9 Biosensors: Recent Advances [PDF]
Sensors, 2018 As one of the most widely investigated matrix metalloproteinases (MMPs), MMP-9 is a significant protease which plays vital roles in many biological processes. MMP-9 can cleave many extracellular matrix (ECM) proteins to regulate ECM remodeling.
Hao Huang
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The Role of MMP-9 and MMP-9 Inhibition in Different Types of Thyroid Carcinoma
Molecules, 2023 Matrix metalloproteinase-9 (MMP-9), one of the most investigated and studied biomarkers of the MMPs family, is a zinc-dependent proteolytic metalloenzyme whose primary function is degrading the extracellular matrix (ECM).
Zhenshengnan Li +6 more
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The usefulness of MMP-9, TIMP-1 and MMP-9/TIMP-1 ratio for diagnosis and assessment of COPD severity [PDF]
European Journal of Medical Research, 2023 Background Inflammation, oxidative stress and an imbalance between proteases and protease inhibitors are recognized pathophysiological features of chronic obstructive pulmonary disease (COPD).
Sanja Dimic-Janjic +12 more
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Does the functional polymorphism-1562C/T of MMP-9 gene influence brain disorders?
Frontiers in Cellular Neuroscience, 2023 Metalloproteinase-9 (MMP-9) is one of the most strongly expressed matrix metalloproteinases (MMPs) in the brain. The MMP-9 activity in the brain is strictly regulated, and any disruptions in this regulation contribute to a development of many disorders ...
Sylwia Pabian-Jewuła, Marcin Rylski
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BMC Microbiology, 2023 Metalloproteinases (MMPs) are remarkable zinc-dependent endopeptidases, critical for degrading components of the extracellular matrix, thus actively influencing cell migration.
Brenda Furtado Costa +6 more
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Inhibition of MMP-9-dependent Degradation of Gelatin, but Not Other MMP-9 Substrates, by the MMP-9 Hemopexin Domain Blades 1 and 4 [PDF]
Journal of Biological Chemistry, 2016 Degradation and remodeling of the extracellular matrix by matrix metalloproteinases (MMPs) plays important roles in normal development, inflammation, and cancer. MMP-9 efficiently degrades the extracellular matrix component gelatin, and the hemopexin domain of MMP-9 (PEX9) inhibits this degradation.
Ugarte Berzal, Estefanía +4 more
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Zaporožskij Medicinskij Žurnal, 2020 Aim – to study the features of immunohistochemical expression of MMP-9, TIMP-1, MMP/TIMP ratio in the cerebral cortex in diabetes mellitus type 2. Materials and methods.
V. O. Shavrin , Yu. M. Avramenko
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Localization Of MMP-2 And MMP-9 In Canine Mammary Gland During Pregnancy [PDF]
Journal of Biomedical & Clinical Research, 2014 The mammary gland is unique in its development because most of its branching occurs in adolescent rather than in prenatal development. During early pregnancy extensive ductal side branching occurs while during the second half, secretory lobuloalveolar ...
Despina Pupaki +3 more
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Functional MMP-9 polymorphisms modulate plasma MMP-9 levels in multiple sclerosis patients [PDF]
Journal of Neuroimmunology, 2012 We have described that MMP-9 C(-1562)T and (CA)(n) polymorphisms contribute to multiple sclerosis (MS). Here, we evaluate whether plasma MMP-9 levels are related to disease severity, drug therapy resistance and polymorphisms. For sub-study 1, 36 patients with MS and 35 controls were recruited.
Fernandes, Karla Simone da Silva +6 more
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Changes of Serum Concentrations of Alkaline Phosphatase and Metalloproteinase-9 in an Ovariectomized Wistar Rat Model of Osteoporosis [PDF]
Journal of Biomedical & Clinical Research, 2017 Osteoporosis is a systemic skeletal disease characterized by decreased bone mass, destruction of the microarchitectonics of bone structure and a high risk for fracture. One of the criteria for altered bone homeostasis includes the changes in serum levels
Alexander Blagev +5 more
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