Results 1 to 10 of about 30,209,850 (267)

Secang wood (Caesalpinia sappan L.) nanoemulgel activity as antiaging through suppressing the MMP-1 expression and the collagen degradation [PDF]

Journal of Pharmacy & Pharmacognosy Research, 2022
Context: Aging is closely related to reactive oxygen species (ROS). ROS increases the collagenase enzyme (MMP-1) levels and collagen degradation that causes skin wrinkling.
Ni Putu Linda Laksmiani, Ni Putu Eka Leliqia, Ni Luh Putu Vidya Paramita, I Gusti Kamasan Nyoman Arijana, Ni Putu Ayu Dewi Wijayanti, Putu Ivan Adiwibawa, I Made Harimbawa Putra, I Putu Ari Anggara Catur Pratama   +7 more
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Macrophage Migration Inhibitory Factor Promotes Expression of Matrix Metalloproteinases 1 and 3 in Spinal Cord Astrocytes following Gecko Tail Amputation

Journal of Integrative Neuroscience, 2023
Background: The matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that play a variety of physiological and pathological roles in development, remodeling of tissues and diseases, mainly through degradation of various components of the ...
Haijun Zhang, Chunshuai Sun, Bingqiang He, Xingyuan Zhang, Huifei Hao, Yuxuan Hou, Aicheng Li, Yongjun Wang, Yingjie Wang   +8 more
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Metformin alleviates intervertebral disc degeneration by upregulating MMP-1 expression via the KDM6A/SOX9/miR-202-3p/MMP-1 signaling pathway

Archives of Medical Science, 2021
Introduction MiR-202-3p is involved in the pathogenesis of intervertebral disc degeneration (IDD) via regulating MMP-1 expression in neuronal precursor cells (NPCs).
Xin-Yao Hu, Dong-Zi Cao, Zhi-Hua Wang
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Effects of Oral and Topical Application of Centella asiatica Extracts on The UVB-Induced Photoaging of Hairless Rats [PDF]

Journal of Pure and Applied Chemistry Research, 2019
Chronic exposure to UVB irradiation can caused premature skin aging (photoaging), as it can trigger the production of ROS and initiate both oxidative stress in cell membrane and affect the molecular pathway.
Yeny Diah Rahmawati, Aulanni’am Aulanni’am, Sasangka Prasetyawan   +2 more
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Role of Matrix Metalloproteinases and Their Inhibitors in Locally Invasive Papillary Thyroid Cancer

Biomedicines, 2022
Locally invasive papillary thyroid carcinoma (PTC) protrudes beyond the thyroid capsule and invades local structures. Matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) are implicated in local invasion and metastasis in PTC.
Irena Ivković, Zgjim Limani, Antonia Jakovčević, Dražen Huić, Drago Prgomet   +4 more
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The effect of micronutrients on postpartum pelvic organ prolapse patients

Majalah Obstetri dan Ginekologi, 2023
HIGHLIGHTS • Serum vitamin D levels were significantly different between POP and in healthy women. • Micronutrient MMP-1 expression is increased in POP patients.   ABSTRACT Objective: Pelvic Organ Prolapse (POP) is when pelvic tissues sink into
Rahajeng, Mukhamad Nooryanto, Muhammad Dzikrifishofa   +2 more
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Anticatabolic and Anti-Inflammatory Effects of Myricetin 3-O-β-d-Galactopyranoside in UVA-Irradiated Dermal Cells via Repression of MAPK/AP-1 and Activation of TGFβ/Smad

Molecules, 2020
UV irradiation is one of the main causes of extrinsic skin aging. UV-mediated skin aging, also known as photoaging, causes excessive breakdown of extracellular matrix which leads skin to lose its elasticity and strength.
Jung Hwan Oh, Fatih Karadeniz, Jung Im Lee, So Young Park, Youngwan Seo, Chang-Suk Kong   +5 more
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Molecular Mechanisms of Inhibitory Effects of Bovine Lactoferrin on Invasion of Oral Squamous Cell Carcinoma

Pharmaceutics, 2023
Lactoferrin (LF), an iron-binding glycoprotein, has been reported to have anticancer properties. However, the molecular mechanisms behind its anticancer effects on oral squamous cell carcinoma (OSCC) have not yet been elucidated.
Chanbora Chea, Mutsumi Miyauchi, Toshihiro Inubushi, Kana Okamoto, Sivmeng Haing, Takashi Takata   +5 more
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Soya-cerebroside reduces IL-1β-induced MMP-1 production in chondrocytes and inhibits cartilage degradation: implications for the treatment of osteoarthritis

Food and Agricultural Immunology, 2019
Osteoarthritis (OA) commonly affects the synovial joint and is characterized by degradation of articular cartilage, which is largely mobilized by increased matrix metalloproteinase (MMP) activity.
Shan-Chi Liu, Chun-Hao Tsai, Tung-Ying Wu, Chang-Hai Tsai, Fuu-Jen Tsai, Jing-Gung Chung, Chih-Yang Huang, Jai-Sing Yang, Yuan-Man Hsu, Mei-Chin Yin, Yang-Chang Wu, Chih-Hsin Tang   +11 more
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The Anterior-Based Muscle-Sparing Approach for Conversion Total Hip Arthroplasty is Safe and Effective

Arthroplasty Today
Background: Total hip arthroplasty (THA) after prior hip or acetabular fracture fixation is considered higher risk than primary THA, as studies have shown reduced implant survival and higher infection rates.
Catherine M. Call, MD, Johanna Mackenzie, MPH, Zoë A. Walsh, MPH, Bailey Shevenell, BA, George Babikian, MD, Brian J. McGrory, MD, MS, Adam J. Rana, MD   +6 more
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