Results 1 to 10 of about 183,240 (268)

Metformin alleviates intervertebral disc degeneration by upregulating MMP-1 expression via the KDM6A/SOX9/miR-202-3p/MMP-1 signaling pathway [PDF]

Archives of Medical Science, 2021
Introduction MiR-202-3p is involved in the pathogenesis of intervertebral disc degeneration (IDD) via regulating MMP-1 expression in neuronal precursor cells (NPCs).
Xin-Yao Hu, Dong-Zi Cao, Zhi-Hua Wang
doaj   +2 more sources

Secang wood (Caesalpinia sappan L.) nanoemulgel activity as antiaging through suppressing the MMP-1 expression and the collagen degradation [PDF]

Journal of Pharmacy & Pharmacognosy Research, 2022
Context: Aging is closely related to reactive oxygen species (ROS). ROS increases the collagenase enzyme (MMP-1) levels and collagen degradation that causes skin wrinkling.
Ni Putu Linda Laksmiani, Ni Putu Eka Leliqia, Ni Luh Putu Vidya Paramita, I Gusti Kamasan Nyoman Arijana, Ni Putu Ayu Dewi Wijayanti, Putu Ivan Adiwibawa, I Made Harimbawa Putra, I Putu Ari Anggara Catur Pratama   +7 more
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Macrophage Migration Inhibitory Factor Promotes Expression of Matrix Metalloproteinases 1 and 3 in Spinal Cord Astrocytes following Gecko Tail Amputation

Journal of Integrative Neuroscience, 2023
Background: The matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that play a variety of physiological and pathological roles in development, remodeling of tissues and diseases, mainly through degradation of various components of the ...
Haijun Zhang, Chunshuai Sun, Bingqiang He, Xingyuan Zhang, Huifei Hao, Yuxuan Hou, Aicheng Li, Yongjun Wang, Yingjie Wang   +8 more
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Role of Matrix Metalloproteinases and Their Inhibitors in Locally Invasive Papillary Thyroid Cancer

Biomedicines, 2022
Locally invasive papillary thyroid carcinoma (PTC) protrudes beyond the thyroid capsule and invades local structures. Matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) are implicated in local invasion and metastasis in PTC.
Irena Ivković, Zgjim Limani, Antonia Jakovčević, Dražen Huić, Drago Prgomet   +4 more
doaj   +1 more source

Stimulation of MMP-1 and CCL2 by NAMPT in PDL Cells [PDF]

Mediators of Inflammation, 2013
Periodontitis is an inflammatory disease caused by pathogenic microorganisms and characterized by the destruction of the periodontium. Obese individuals have an increased risk of periodontitis, and elevated circulating levels of adipokines, such as nicotinamide phosphoribosyltransferase (NAMPT), may be a pathomechanistic link between both diseases. The
Marjan Nokhbehsaim, Sigrun Eick, Andressa Vilas Boas Nogueira, Per Hoffmann, Stefan Herms, Holger Fröhlich, Søren Jepsen, Andreas Jäger, Joni Augusto Cirelli, James Deschner   +9 more
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The Effect of MMP-1 on Wound Healing and Scar Formation

Aesthetic Plastic Surgery, 2021
In this study, we investigated the effect of matrix metalloproteinase-1 (MMP-1) on wound healing on skin in a model produced in rats.Sixteen Sprague-Dawley male rats were included in the study. The four full-thickness skin wound was created on the dorsal area of each rat with 4.4 mm punch. The rats were randomly divided into two groups.
Elif Seda Keskin, Ekrem Ramazan Keskin, Muhammed Beşir Öztürk, Dogan Çakan   +3 more
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Effects of Oral and Topical Application of Centella asiatica Extracts on The UVB-Induced Photoaging of Hairless Rats [PDF]

Journal of Pure and Applied Chemistry Research, 2019
Chronic exposure to UVB irradiation can caused premature skin aging (photoaging), as it can trigger the production of ROS and initiate both oxidative stress in cell membrane and affect the molecular pathway.
Yeny Diah Rahmawati, Aulanni’am Aulanni’am, Sasangka Prasetyawan   +2 more
doaj   +1 more source

The clinical significance of MMP-1 expression in oesophageal carcinoma [PDF]

British Journal of Cancer, 2001
Matrix metalloproteinase-1 (MMP-1) is involved in the degradation of interstitial collagen and thus thought to play a role in invasion of carcinoma. We investigated 51 oesophageal carcinoma patients to clarify the significance of MMP-1. MMP-1 mRNA was demonstrated to be expressed exclusively in almost all carcinoma tissue specimens (T) (94.1%) by ...
Yamashita, K, Mori, M, Kataoka, A, Inoue, H, Sugimachi, K   +4 more
openaire   +2 more sources

MMP-1 gene polymorphism in osteoporosis.

European review for medical and pharmacological sciences, 2019
To investigate the correlation of osteoporosis (OP) with matrix metalloproteinase-1 (MMP-1) gene polymorphism.A total of 199 patients as observation group (OP) and 180 healthy subjects (control group) were enrolled in the study, and the general data, the expression levels of serum calcium, serum phosphate and MMP-1 were collected and determined.
Liang, L., Zhu, D.-P., Guo, S.-S., Zhang, D., Zhang, T.   +4 more
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Influence of variations across the MMP-1 and -3 genes on the serum levels of MMP-1 and -3 and disease activity in rheumatoid arthritis [PDF]

Genes & Immunity, 2011
Matrix metalloproteinases (MMPs) are involved in joint destruction in rheumatoid arthritis (RA), and are strongly associated with levels of inflammation. To understand the relationship between MMP-1 and -3 variants and MMP levels in RA, we investigated the genotypic and haplotypic relationships of the MMP-1 and -3 genes with circulating levels of these
Y, Chen, N B, Nixon, P T, Dawes, D L, Mattey   +3 more
openaire   +2 more sources