Results 1 to 10 of about 201,590 (310)

Metformin alleviates intervertebral disc degeneration by upregulating MMP-1 expression via the KDM6A/SOX9/miR-202-3p/MMP-1 signaling pathway

Archives of Medical Science, 2021
Introduction MiR-202-3p is involved in the pathogenesis of intervertebral disc degeneration (IDD) via regulating MMP-1 expression in neuronal precursor cells (NPCs).
Xin-Yao Hu, Dong-Zi Cao, Zhi-Hua Wang
doaj   +2 more sources

Secang wood (Caesalpinia sappan L.) nanoemulgel activity as antiaging through suppressing the MMP-1 expression and the collagen degradation [PDF]

Journal of Pharmacy & Pharmacognosy Research, 2022
Context: Aging is closely related to reactive oxygen species (ROS). ROS increases the collagenase enzyme (MMP-1) levels and collagen degradation that causes skin wrinkling.
Ni Putu Linda Laksmiani, Ni Putu Eka Leliqia, Ni Luh Putu Vidya Paramita, I Gusti Kamasan Nyoman Arijana, Ni Putu Ayu Dewi Wijayanti, Putu Ivan Adiwibawa, I Made Harimbawa Putra, I Putu Ari Anggara Catur Pratama   +7 more
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Macrophage Migration Inhibitory Factor Promotes Expression of Matrix Metalloproteinases 1 and 3 in Spinal Cord Astrocytes following Gecko Tail Amputation

Journal of Integrative Neuroscience, 2023
Background: The matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that play a variety of physiological and pathological roles in development, remodeling of tissues and diseases, mainly through degradation of various components of the ...
Haijun Zhang, Chunshuai Sun, Bingqiang He, Xingyuan Zhang, Huifei Hao, Yuxuan Hou, Aicheng Li, Yongjun Wang, Yingjie Wang   +8 more
doaj   +1 more source

Role of Matrix Metalloproteinases and Their Inhibitors in Locally Invasive Papillary Thyroid Cancer

Biomedicines, 2022
Locally invasive papillary thyroid carcinoma (PTC) protrudes beyond the thyroid capsule and invades local structures. Matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) are implicated in local invasion and metastasis in PTC.
Irena Ivković, Zgjim Limani, Antonia Jakovčević, Dražen Huić, Drago Prgomet   +4 more
doaj   +1 more source

MMP-1 serum levels predict coronary atherosclerosis in humans [PDF]

Cardiovascular Diabetology, 2009
Myocardial infarction results as a consequence of atherosclerotic plaque rupture, with plaque stability largely depending on the lesion forming extracellular matrix components. Lipid enriched non-calcified lesions are considered more instable and rupture prone than calcified lesions.
Lehrke, Michael, Greif, Martin, Broedl, Uli C., Lebherz, Corinna, Laubender, Rüdiger P., Becker, Alexander, Ziegler, Franz von, Tittus, Janine, Reiser, Maximilian, Becker, Christoph, Göke, Burkhard, Steinbeck, Gerhard, Leber, Alexander W., Parhofer, Klaus G.   +13 more
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Interdomain Flexibility in Full-length Matrix Metalloproteinase-1 (MMP-1) [PDF]

Journal of Biological Chemistry, 2009
The presence of extensive reciprocal conformational freedom between the catalytic and the hemopexin-like domains of full-length matrix metalloproteinase-1 (MMP-1) is demonstrated by NMR and small angle x-ray scattering experiments. This finding is discussed in relation to the essentiality of the hemopexin-like domain for the collagenolytic activity of ...
BERTINI, IVANO, FRAGAI, MARCO, LUCHINAT, CLAUDIO, MELIKIAN, MAXIME THIERRY OLIVIER, E. Mylonas, SARTI, NIKO, D. Svergun   +6 more
openaire   +3 more sources

Effects of Oral and Topical Application of Centella asiatica Extracts on The UVB-Induced Photoaging of Hairless Rats [PDF]

Journal of Pure and Applied Chemistry Research, 2019
Chronic exposure to UVB irradiation can caused premature skin aging (photoaging), as it can trigger the production of ROS and initiate both oxidative stress in cell membrane and affect the molecular pathway.
Yeny Diah Rahmawati, Aulanni’am Aulanni’am, Sasangka Prasetyawan   +2 more
doaj   +1 more source

The catalytic domain of MMP‐1 studied through tagged lanthanides [PDF]

FEBS Letters, 2011
Pseudocontact shifts (pcs) and paramagnetic residual dipolar couplings (rdc) provide structural information that can be used to assess the adequacy of a crystallographic structure to represent the solution structure of a protein. This can be done by attaching a lanthanide binding tag to the protein.
BERTINI, IVANO, CALDERONE, VITO, CEROFOLINI, LINDA, FRAGAI, MARCO, C. F. Geraldes, P. Hermann, LUCHINAT, CLAUDIO, PARIGI, GIACOMO, J. M. Teixeira   +8 more
openaire   +4 more sources

The effect of micronutrients on postpartum pelvic organ prolapse patients

Majalah Obstetri dan Ginekologi, 2023
HIGHLIGHTS • Serum vitamin D levels were significantly different between POP and in healthy women. • Micronutrient MMP-1 expression is increased in POP patients.   ABSTRACT Objective: Pelvic Organ Prolapse (POP) is when pelvic tissues sink into
Rahajeng, Mukhamad Nooryanto, Muhammad Dzikrifishofa   +2 more
doaj   +1 more source

MMP-1 gene polymorphism in osteoporosis.

European review for medical and pharmacological sciences, 2019
To investigate the correlation of osteoporosis (OP) with matrix metalloproteinase-1 (MMP-1) gene polymorphism.A total of 199 patients as observation group (OP) and 180 healthy subjects (control group) were enrolled in the study, and the general data, the expression levels of serum calcium, serum phosphate and MMP-1 were collected and determined.
Liang, L., Zhu, D.-P., Guo, S.-S., Zhang, D., Zhang, T.   +4 more
openaire   +2 more sources