Results 21 to 30 of about 700,907 (294)

Role of Gene Polymorphisms of Matrix Metalloproteinases-2, -3 and -13 in the Development of Coronary Artery Atherosclerosis in Patients with Primary Polyosteoarthrosis

Архивъ внутренней медицины, 2020
The aim of the research. To assess the influence of polymorphisms of the matrix metalloproteinase genes — 2 (rs2285053), — 3 (rs3025058), and — 13 (rs2252070) on the development of coronary atherosclerosis in patients with primary osteoarthritis ...
O. O. Portyannikova, E. N. Romanova, A. V. Govorin, S. M. Tsvinger   +3 more
doaj   +1 more source

The intestinal sutures insufficiency: factors of risk and prognostication, based on genetic investigations

Клінічна хірургія, 2022
Objective. To improve the results of treatment in patients, suffering insufficiency of sutures of intestinal anastomoses, using analysis of rate in the genes polymorphous variants of the matrix metalloproteinase Type 2 (C-1306 →T) and the tissue ...
O. Yu. Usenko, Ya. Yu. Voitiv
doaj   +1 more source

Gelatinases A and B activities in the serum of patients with various coronary artery disease stages [PDF]

Vojnosanitetski Pregled, 2010
Background/Aim. The main characteristic of matrix metalloproteinases (MMPs) is the degradation of extracellular matrix. Synthesis of MMPs has been reported in coronary atherosclerotic lesions in patients with coronary disease (CD) suggesting a pathogenic
Radenković Sandra, Brajović Milan, Konjević Gordana, Gopčević Kristina   +3 more
doaj   +1 more source

The Role of Matrix Metalloproteinase-2 and Matrix Metalloproteinase-9 in Antibody-Induced Arthritis [PDF]

The Journal of Immunology, 2002
Abstract Matrix metalloproteinases (MMPs) are a large group of enzymes responsible for matrix degradation. Among them, the family of gelatinases (MMP-2/gelatinase A and MMP-9/gelatinase B) is overproduced in the joints of patients with rheumatoid arthritis.
Takeshi, Itoh, Hidetoshi, Matsuda, Masatoshi, Tanioka, Kenji, Kuwabara, Shigeyoshi, Itohara, Ryuji, Suzuki   +5 more
openaire   +2 more sources

The Significance of Matrix Metalloproteinase 9 (MMP-9) and Metalloproteinase 2 (MMP-2) in Urinary Bladder Cancer

Biomedicines, 2023
Introduction: Urinary bladder cancer is a serious oncological problem that is the cause of many deaths worldwide. The processes of metastasis and origination of local tumor invasion depend on the extracellular matrix (ECM) degradation.
Jacek Kudelski, Anna Tokarzewicz, Monika Gudowska-Sawczuk, Barbara Mroczko, Piotr Chłosta, Marta Bruczko-Goralewska, Przemysław Mitura, Grzegorz Młynarczyk   +7 more
doaj   +1 more source

MMP-2 together with MMP-9 overexpression correlated with lymph node metastasis and poor prognosis in early gastric carcinoma

Tumor Biology, 2017
The aim of this study was to correlate matrix metalloproteinase-2 and matrix metalloproteinase-9 expression with the clinicopathological features and outcome of patients with early gastric cancer and to clinically elucidate more information on the role ...
Zhihua Yao, Tian Yuan, Haiying Wang, Shuna Yao, Yan Zhao, Ying Liu, Shuiling Jin, Junfeng Chu, Yuanlin Xu, Wenping Zhou, Shujun Yang, Yanyan Liu   +11 more
doaj   +1 more source

Expression and prognostic impact of matrix metalloproteinase-2 (MMP-2) in astrocytomas

PLoS ONE, 2017
Astrocytomas are the most frequent primary brain tumors in adults, and despite aggressive treatment patients often experience recurrence. Survival decreases with increasing tumor grade, and especially patients with grade IV glioblastoma have poor ...
R. K. Ramachandran, M. D. Sørensen, C. Aaberg-Jessen, S. K. Hermansen, B. Kristensen   +4 more
semanticscholar   +1 more source

Cleavage of the leptin receptor by matrix metalloproteinase–2 promotes leptin resistance and obesity in mice

Science Translational Medicine, 2018
Matrix metalloproteinase–2 inhibition rescued leptin receptor expression in the hypothalamus and reduced fat accumulation in rodent models of obesity.
R. Mazor, D. Friedmann-Morvinski, T. Alsaigh, O. Kleifeld, E. Kistler, L. Rousso-Noori, Cheng Huang, Joyce B. Li, I. Verma, G. Schmid-Schönbein   +9 more
semanticscholar   +1 more source

Microtubule-Dependent Matrix Metalloproteinase-2/Matrix Metalloproteinase-9 Exocytosis [PDF]

Cancer Research, 2004
Abstract Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that cleave and degrade a wide spectrum of extracellular matrix components. By enhancing turnover of extracellular matrix, MMP activity is also known to play a key role in tumor cell invasion.
Eva-Maria Schnaeker, Rainer Ossig, Thomas Ludwig, Rita Dreier, Hans Oberleithner, M. Wilhelmi, Stefan W. Schneider   +6 more
openaire   +1 more source

Expression of matrix metalloproteinase-2 and 9 with their inhibitors, tissue inhibitors of metalloproteinase-1 and 2 in oral lichen planus

Journal of Orofacial Sciences, 2014
Objectives: The study aims to explore the expression of the matrix metalloproteinases (MMP-2, -9) and their inhibitors (tissue inhibitors of metalloproteinase [TIMP]-1, -2) as well as the correlation between them in the different morphological forms of ...
Natheer Hashim Al-Rawi, Thaer Kassim Al-Kassam, Ahlam Hameed Majeed   +2 more
doaj   +1 more source