Results 1 to 10 of about 157,031 (257)

Development of Matrix Metalloproteinase-2 Inhibitors for Cardioprotection [PDF]

Frontiers in Pharmacology, 2018
The objective of our present study is to develop novel inhibitors for MMP-2 for acute cardioprotection. In a series of pilot studies, novel substituted carboxylic acid derivatives were synthesized based on imidazole and thiazole scaffolds and then tested
Péter Bencsik, Péter Bencsik, Krisztina Kupai, Anikó Görbe, Anikó Görbe, Éva Kenyeres, Éva Kenyeres, Zoltán V. Varga, János Pálóczi, Renáta Gáspár, László Kovács, Lutz Weber, Ferenc Takács, István Hajdú, István Hajdú, Gabriella Fabó, Sándor Cseh, László Barna, László Barna, Tamás Csont, Csaba Csonka, György Dormán, Péter Ferdinandy, Péter Ferdinandy   +23 more
doaj   +5 more sources

Investigating salivary matrix metalloproteinase-2 and matrix metalloproteinase-9 activity in fixed orthodontic-induced gingival enlargement [PDF]

Dental Research Journal
Background: Gingival enlargement (GE) is a common clinical observation among orthodontic patients, yet its underlying causes remain unclear. This study aims to investigate the potential involvement of salivary matrix metalloproteinase (MMP)-2 and MMP-9 ...
Narges Ziaei, Amir Kiani, Ehsan Mohammadi-Noori, Shahram Arishi, Shima Golmohammadi   +4 more
doaj   +2 more sources

Chlorotoxin does not target matrix metalloproteinase-2 in glioblastoma. [PDF]

PLoS ONE
Glioblastoma aggressively invades surrounding tissue by expressing matrix metalloproteinase-2 (MMP-2). Therefore, effective inhibition of MMP-2 is a desirable target for treatment.
Eli Blaney, Meron Demeke, Seraphine Kamayirese, Louise Monga, Laura A Hansen, Charles R Watts, Sándor Lovas   +6 more
doaj   +2 more sources

Contribution of Matrix Metalloproteinase-2 and Matrix Metalloproteinase-9 to Upper Tract Urothelial Cancer Risk in Taiwan [PDF]

Life
Matrix metalloproteinase (MMP)-2 and -9, which degrade type IV collagen, are linked to cancer invasion and metastasis. Gene polymorphisms in MMP-2 and MMP-9 can influence their function, impacting cancer development and progression.
Bo-Ren Wang, Hung-Huan Ma, Chao-Hsiang Chang, Cheng-Hsi Liao, Wen-Shin Chang, Mei-Chin Mong, Ya-Chen Yang, Jian Gu, Da-Tian Bau, Chia-Wen Tsai   +9 more
doaj   +2 more sources

Prognostic impact of matrix metalloproteinase 2 (MMP-2) and matrix metalloproteinase 9 (MMP-9) in Egyptian breast cancer patients [PDF]

International Journal of Immunopathology and Pharmacology
This study aims to investigate the diagnostic and prognostic relevance of MMP-2 and MMP-9 as biomarkers for breast cancer, as well as their association with clinicopathological factors.
Fayrouz A Fouad, Mohamed A Khali, Inas Moaz, Hossam Elmasry, Nada Gheta, Asala Abdeen, Mariam Tantawi, Ganna Elkholy, Shaimaa Rihan, Mahmoud M Kamel, Ayman EL-Meghawry EL-Kenawy, Youssef AS Abdel-Moneim, Abdallah M Gameel   +12 more
doaj   +2 more sources

Expression of RECK and matrix metalloproteinase-2 in ameloblastoma [PDF]

BMC Cancer, 2009
Background Ameloblastoma is a frequent odontogenic benign tumor characterized by local invasiveness, high risk of recurrence and occasional metastasis and malignant transformation.
Xie Hong-Liang, Xu Zhi-Ying, Zhang Jin, Zhang Bin   +3 more
doaj   +3 more sources

Prognostic values of matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 expression in bladder cancer [PDF]

Cancer, 1998
Matrix metalloproteinase-2 (MMP-2), which degrades the extracellular matrix or the basement membrane, has an essential role in tumor invasion and metastasis. To evaluate the roles of MMP-2, its inhibitor (tissue inhibitor of metalloproteinase-2 [TIMP-2]), and its activator (membrane-type matrix metalloproteinase-1 [MT1-MMP]) in tumor invasion or as a ...
Susumu Kagawa, Masaaki Nishitani, Yasushi Kurokawa   +2 more
exaly   +3 more sources

Prognostic value of matrix metalloproteinase-2 protein and matrix metalloproteinase-9 protein in colorectal cancer: a meta-analysis [PDF]

BMC Cancer
Introduction Matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) are critical components of the extracellular matrix (ECM) in colorectal cancer (CRC). We aimed to evaluate the prognostic value of MMP-2 and MMP-9 in patients with CRC.
Yusha Wang, Yuhao Wei, Jing Huang, Xinke Li, Diqing You, Li Wang, Xuelei Ma   +6 more
doaj   +2 more sources

The role of MMP-2 and MMP-9 in the metastasis and development of hypopharyngeal carcinoma

Brazilian Journal of Otorhinolaryngology, 2021
Introduction: The role of matrix metalloproteinase-2 and 9 in the metastasis and development of hypopharyngeal carcinoma has not been clarified. Objectives: To observe the relationship between matrix metalloproteinase-2, matrix metalloproteinase-9 and ...
Zhe Song, Junfu Wang, Qinghong Su, Meng Luan, Xuemei Chen, Xiaoqun Xu   +5 more
doaj   +1 more source

Regulation of Matrix Metalloproteinase-2 and Matrix Metalloproteinase-9 in Abdominal Aortic Aneurysm

Cardiology Discovery, 2023
Abdominal aortic aneurysm (AAA) is a degenerative disease characterized by destruction and progressive expansion of the abdominal aortic wall. An AAA is typically defined as an enlargement of the abdominal aorta with diameter ≥3 cm or ≥50% greater than ...
Shuo Wang, Dan Liu, Xiaolin Zhang, Xiaoxiang Tian   +3 more
doaj   +1 more source