Results 31 to 40 of about 794,000 (393)

Expression and prognostic impact of matrix metalloproteinase-2 (MMP-2) in astrocytomas

PLoS ONE, 2017
Astrocytomas are the most frequent primary brain tumors in adults, and despite aggressive treatment patients often experience recurrence. Survival decreases with increasing tumor grade, and especially patients with grade IV glioblastoma have poor ...
R. K. Ramachandran, M. D. Sørensen, C. Aaberg-Jessen, S. K. Hermansen, B. Kristensen   +4 more
semanticscholar   +1 more source

Sphingosine 1-phosphate receptor 1 is required for MMP-2 function in bone marrow mesenchymal stromal cells: implications for cytoskeleton assembly and proliferation [PDF]

, 2018
Bone marrow-derived mesenchymal stromal cell- (BM-MSC-) based therapy is a promising option for regenerative medicine. An important role in the control of the processes influencing the BM-MSC therapeutic efficacy, namely, extracellular matrix remodelling
Anderloni, Giulia, Chellini, Flaminia, Frati, Alessia, Matteini, Francesca, Meacci, Elisabetta, Nosi, Daniele, Pierucci, Federica, Sassoli, Chiara, Tani, Alessia, Vestri, Ambra, Zecchi-Orlandini, Sandra   +10 more
core   +4 more sources

Cleavage of the leptin receptor by matrix metalloproteinase–2 promotes leptin resistance and obesity in mice

Science Translational Medicine, 2018
Matrix metalloproteinase–2 inhibition rescued leptin receptor expression in the hypothalamus and reduced fat accumulation in rodent models of obesity.
R. Mazor, D. Friedmann-Morvinski, T. Alsaigh, O. Kleifeld, E. Kistler, L. Rousso-Noori, Cheng Huang, Joyce B. Li, I. Verma, G. Schmid-Schönbein   +9 more
semanticscholar   +1 more source

Attenuation of urokinase activity during experimental ischaemia protects the cerebral barrier from damage through regulation of matrix metalloproteinase-2 and NAD(P)H oxidase [PDF]

, 2014
Ischaemic injury impairs the integrity of the blood–brain barrier (BBB). In this study, we investigated the molecular causes of this defect with regard to the putative correlations among NAD(P)H oxidase, plasminogen–plasmin system components, and matrix ...
Ahn, Allen, Allen, Allen, Asahi, Asahi, Asahi, Baramova, Barr, Bayraktutan, Brouns, Cavdar, Chen, Chen, Cho, Chrissobolis, Ear, Eltzschig, Fuhrman, Hacke, Haworth, Hayashi, Hayashi, Higazi, Hong, Hosomi, Irigoyen, Kleikers, Kleinschnitz, Liu, Lucivero, Margaill, Nakase, Persidsky, Raat, Rosenberg, Selemidis, Shao, Shuaib, Suofu, Tahanian, Thornton, Tsuji, Walder, Wang, Wang   +45 more
core   +2 more sources

Amentoflavone, a potent natural matrix metalloproteinase 2 inhibitor

Natural Product Research, 2023
Gelatinase A (MMP-2) has been studied and proven to play a vital role in the intrusion and metastasis of cancer. Flavonoids influence on molecular and cellular functions of MMP-2 and thus a systematic investigation of flavonoids against the metalloproteolytic activity of MMP-2 has been performed in this study.
Seri Jo, Mi-Sun Kim, Hwa-Young Kim, Suwon Kim, Heejin Kam, Haein Choi, Dong Hae Shin   +6 more
openaire   +2 more sources

Expression of matrix metalloproteinase-2 and 9 with their inhibitors, tissue inhibitors of metalloproteinase-1 and 2 in oral lichen planus

Journal of Orofacial Sciences, 2014
Objectives: The study aims to explore the expression of the matrix metalloproteinases (MMP-2, -9) and their inhibitors (tissue inhibitors of metalloproteinase [TIMP]-1, -2) as well as the correlation between them in the different morphological forms of ...
Natheer Hashim Al-Rawi, Thaer Kassim Al-Kassam, Ahlam Hameed Majeed   +2 more
doaj   +1 more source

Matrix metalloproteinases in liver injury, repair and fibrosis. [PDF]

, 2015
The liver is a large highly vascularized organ with a central function in metabolic homeostasis, detoxification, and immunity. Due to its roles, the liver is frequently exposed to various insults which can cause cell death and hepatic dysfunction ...
Baber, John, Coito, Ana J, Duarte, Sergio, Fujii, Takehiro   +3 more
core   +1 more source

The extracellular matrix degradation markers as predictors of left ventricular systolic dysfunction among patients with STEMI

Сучасні медичні технології, 2021
The purpose of the study. To determine predictor value of the extracellular matrix degradation markers relative to the occurrence of left ventricular systolic dysfunction among patients with STEMI determined. Materials and methods.
I. M. Fushtey, E. V. Sid
doaj   +1 more source

The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) family [PDF]

, 2015
The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) enzymes are secreted, multi-domain matrix-associated zinc metalloendopeptidases that have diverse roles in tissue morphogenesis and patho-physiological remodeling, in ...
A Colige, A Didangelos, A Luque, A Moncada-Pazos, A Noel, A Tan Ide, AC Jonsson-Rylander, AC Nicholson, AJ Fosang, B Joe, BH Koo, BH Koo, BV Nusgens, C Casal, C Esselens, C Gendron, C Kintakas, C Lopez-Otin, C Ricciardelli, CB Kern, CG Viloria, CH Mjaatvedt, CJ Liu, CJ Liu, CL Jacobi, CM Dancevic, CN Brocker, CR Flannery, D Wagsater, DL Russell, DL Silver, DR Edwards, DR McCulloch, DT Jones, Dylan R Edwards, EA Lin, EC Arner, ED Karagiannis, EM Majerus, F Guo, F Vazquez, FG Brunet, FX Gomis-Ruth, FX Gomis-Ruth, G Gao, G Gao, G Hashimoto, G Murphy, GC Choi, GE Lind, GG Levy, GJ Wayne, Grant N Wheeler, H Enomoto, H Jin, H Stanton, H Stanton, HL Lung, HM Brown, I Abbaszade, I Peluso, Ines Desanlis, J Dubail, J Dubail, J Felsenstein, J Hofsteenge, J Huxley-Jones, J Huxley-Jones, J Morales, JA Pyun, JC Adams, JC Rodriguez-Manzaneque, JC Rodriguez-Manzaneque, JC Rodriguez-Manzaneque, JD Sandy, JM Longpre, K Demircan, K Fujikawa, K Gopalakrishnan, K Kuno, K Kuno, K Stankunas, K Tamura, K Yamamoto, K Yamamoto, L Angerer, L Faivre, L Mittaz, L Mosyak, L Troeberg, L Troeberg, L Troeberg, L Wagstaff, LA Collins-Racie, LE Dupuis, LM Ricketts, M Cudic, M Hour El, M Kashiwagi, M Krampert, M Llamazares, MA Aldahmesh, MD Tortorella, MN Vankemmelbeke, N Dagoneau, N Hattori, N Rocks, N Rocks, N Stupka, NH Lim, NV Lee, NV Lee, P Wang, PH Lo, PJ Koshy, PS Chockalingam, R Kelwick, RC Salter, RH Song, Richard Kelwick, RL Robker, RP Somerville, RP Somerville, RS Patel, S Abdul-Majeed, S Gerhardt, S Kumar, S Kumar, S Nandadasa, S Porter, S Porter, SS Apte, SS Glasson, T Fontanil, T Shindo, TN Wight, U Auf Dem Keller, W Du, W Zeng, WE Kutz, WM Wang, X Lu, X Pu, XL Zheng, YJ Liu, YP Hsu   +145 more
core   +1 more source

ELISA study of matrix metalloproteinases 2, 7, 9 and their type 2 tissue inhibitor in the tumors of gastric cancer patients: clinical and pathologic correlations

Alʹmanah Kliničeskoj Mediciny, 2018
Background: Over the last 10 years the incidence of gastric cancer has declined significantly. Nevertheless, it remains one of the most prevalent malignancies both in Russia and worldwide.
E. S. Gershtein, A. A. Ivannikov, V. L. Chang, N. A. Ognerubov, М. M. Davydov, I. S. Stilidi, N. E. Kushlinskii   +6 more
doaj   +1 more source