Results 21 to 30 of about 151,446 (258)

Inhibition of matrix metalloproteinase-2 by PARP inhibitors [PDF]

Biochemical and Biophysical Research Communications, 2009
Matrix metalloproteinase-2 (MMP-2), a ubiquitously expressed zinc-dependent endopeptidase, and poly(ADP-ribosyl) polymerase (PARP), a nuclear enzyme regulating DNA repair, are activated by nitroxidative stress associated with various pathologies. As MMP-2 plays a detrimental role in heart injuries resulting from enhanced nitroxidative stress, where ...
Adrian C, Nicolescu, Andrew, Holt, Arulmozhi D, Kandasamy, Pal, Pacher, Richard, Schulz   +4 more
openaire   +2 more sources

Serum matrix metalloproteinase 2 and tissue inhibitor of matrix metalloproteinases 2 in esophageal cancer patients

Folia Histochemica et Cytobiologica, 2012
The positive expression of MMP-2 and TIMP-2 were found in esophageal cancer (EC) tissue and correlated with cancer stage and clinico-pathological features of tumor and patients' survival. However, little is known about serum levels of those proteins in EC patients. The aim of the present study was to investigate the diagnostic significance of MMP-2 and
Magdalena, Groblewska, Barbara, Mroczko, Miroslaw, Kozlowski, Jacek, Niklinski, Jerzy, Laudanski, Maciej, Szmitkowski   +5 more
openaire   +3 more sources

Relationships between MMP-2, MMP-9, and ADAMDEC1 serum and tissue levels in patients with colorectal cancer [PDF]

Annals of Coloproctology
Purpose Colorectal cancer (CRC) is the most common malignancy of the gastrointestinal system globally. Identifying specific gene expression patterns indicative of early-stage CRC could enable early diagnosis and rapid treatment initiation.
Zahra Mozooni, Kiana Khajeh Amiri, Nafiseh Golestani, Alireza Shahmohammadi, Sara Minaeian, Leyla Bahadorizadeh   +5 more
doaj   +1 more source

Increased Matrix Metalloproteinase-2 and Matrix Metalloproteinase-3 Concentrations in Corneal Epithelium of Patients with Recurrent Corneal Erosions

Journal of Ophthalmology, 2022
Purpose. To assess the role of selected matrix metalloproteinases in defective corneal re-epithelization in patients with recurrent corneal erosions. Subjects.
Katarzyna Jadczyk-Sorek, Wojciech Garczorz, Beata Bubała-Stachowicz, Tomasz Francuz, Ewa Mrukwa-Kominek   +4 more
doaj   +1 more source

Molecular interactions of tannic acid and matrix metalloproteinases 2 and 9

Computational and Structural Biotechnology Journal, 2023
Tannic acid (TA) has antibacterial, antioxidant, and anti-inflammatory properties and acts as an adhesive, hemostatic, and crosslinking agent in hydrogels.
Ya-Tang Chiang, Yu-Bai Xiao, Shan-hui Hsu, Shu-Wei Chang, Chia-Ching Chou   +4 more
doaj   +1 more source

Expression of matrix metalloproteinase-2 and matrix metalloproteinase-9 in recurrent chronic rhinosinusitis with nasal polyposis

Kaohsiung Journal of Medical Sciences, 2013
Matrix metalloproteinase (MMP) is involved in the upper airway remodeling process. We hypothesized that MMP had an additive effect on the formation of recurrent nasal polyp.
Ling-Feng Wang, Chen-Yu Chien, Feng-Yu Chiang, Chee-Yin Chai, Chih-Feng Tai   +4 more
doaj   +1 more source

In vivo and in vitro efficacy of crocin against Echinococcus multilocularis

Parasites & Vectors, 2021
Background Alveolar echinococcosis (AE) is a fatal zoonosis caused by the larvae of Echinococcus multilocularis. However, current chemotherapy treatment options are based on benzimidazoles [albendazole (ABZ) and mebendazole], which have limited efficacy.
Chuanchuan Liu, Haining Fan, Lu Guan, Ri-li Ge, Lan Ma   +4 more
doaj   +1 more source

Matrix metalloproteinase 2 and tissue inhibitor of matrix metalloproteinases 2 in the diagnosis of colorectal adenoma and cancer patients.

Folia Histochemica et Cytobiologica, 2011
The aim of the study was to assess the importance of the measurement of matrix metalloproteinase 2 (MMP-2) and tissue inhibitor of matrix metalloproteinases 2 (TIMP-2) in patients with colorectal cancer (CRC) in relation to clinicopathological features of tumor and patients' survival.
Magdalena Groblewska, Barbara Mroczko, Mariusz Gryko, Boguslaw Kędra, Maciej Szmitkowski   +4 more
openaire   +5 more sources

Biomarkers of Skin Graft Healing in Venous Leg Ulcers

Acta Dermato-Venereologica, 2022
There is a need for biomarkers that predict the success of transplantation of venous leg ulcers (with autologous split-thickness skin grafts). The primary objective of this exploratory study was to investigate the association between split-thickness skin
Klaus Kirketerp-Møller, Petra Doerfler, Nicole Schoefmann, Barbara Wolf-Winiski, Omid Niazi, Vibeke Pless, Tonny Karlsmark, Magnus Ågren   +7 more
doaj   +1 more source

Common matrix metalloproteinase-2 gene variants and altered susceptibility to breast cancer and associated features in Tunisian women

Tumor Biology, 2019
A role for matrix metalloproteinase polymorphisms in breast cancer development and progression was proposed, but with inconclusive results. We assessed the relation of matrix metalloproteinase-2 variants with breast cancer and related phenotypes in ...
Azza F Habel, Rabeb M Ghali, Hanen Bouaziz, Amira Daldoul, Mariem Hadj-Ahmed, Amina Mokrani, Sonia Zaied, Monia Hechiche, Khaled Rahal, Besma Yacoubi-Loueslati, Wassim Y Almawi   +10 more
doaj   +1 more source