Results 21 to 30 of about 166,368,995 (207)

Structural insight into the complex formation of latent matrix metalloproteinase 2 with tissue inhibitor of metalloproteinase 2 [PDF]

Proceedings of the National Academy of Sciences, 2002
Matrix metalloproteinases (MMPs) are a family of multidomain enzymes involved in the physiological degradation of connective tissue, as well as in pathological states such as tumor invasion and arthritis. Apart from transcriptional regulation, MMPs are controlled by proenzyme activation and a class of specific tissue inhibitors of metalloproteinases ...
Ekaterina, Morgunova, Ari, Tuuttila, Ulrich, Bergmann, Karl, Tryggvason   +3 more
openaire   +2 more sources

Prognostic Significance of Matrix Metalloproteinase 2 and Tissue Inhibitor of Metalloproteinase 2 Expression in Prostate Cancer [PDF]

Modern Pathology, 2003
Matrix metalloproteinases (MMPs) are proteolytic enzymes capable of degrading the structural support network for normal and malignant cells, promoting neoplastic cell invasion and metastasis. Tissue inhibitors of metalloproteinases (TIMPs) maintain connective tissue integrity by modulating MMP activity.
Jeffrey S, Ross, Prabhjot, Kaur, Christine E, Sheehan, Hugh A G, Fisher, Ronald A, Kaufman, Bhaskar V S, Kallakury   +5 more
openaire   +2 more sources

Salivary molecules of bone remodeling and tissue repair after head and neck radiotherapy

Brazilian Oral Research, 2021
Head and neck radiotherapy causes quantitative and qualitative changes in saliva. The objective of this case-control study was to evaluate the salivary biomarkers associated with bone remodeling and tissue repair in patients submitted to radiotherapy for
Eduardo Morato de OLIVEIRA, Rafael Soares GUIEIRO, Bárbara Lima CRUZ, Maria Cássia Ferreira de AGUIAR, Janine Mayra da SILVA, Tarcília Aparecida SILVA, Patrícia Carlos CALDEIRA   +6 more
doaj   +1 more source

Kind of Sample as Preanalytical Determinant of Matrix Metalloproteinases 2 and 9 and Tissue Inhibitor of Metalloproteinase 2 in Blood [PDF]

Clinical Chemistry, 1998
Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) are interesting new diagnostic tools in oncology, liver diseases, and rheumatoid arthritis (1)(2)(3)(4)(5). However, the preanalytical issue of their determination in blood was only recently shown (6).
Jung, K, Laube, C, Lein, M, Lichtinghagen, R, Tschesche, Harald, Schnorr, D, Loening, SA   +6 more
openaire   +3 more sources

Clinical significance of matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 1 and 2 in Kawasaki disease [PDF]

Korean Journal of Pediatrics, 2010
Purpose : Kawasaki disease (KD) is a systemic vasculitis, a leading cause of pediatric acquired heart disease. Histopathological findings of coronary artery lesion (CAL) in KD indicate destruction of the coronary artery wall with diffuse vasculitis ...
Ki Wook Yun, Sin Weon Sin, Jung Ju Lee, Soo Ahn Chae, In Seok Lim, Eung Sang Choi, Byoung Hoon Yoo, Mi-Kyung Lee   +7 more
doaj   +1 more source

An imbalance between matrix metalloproteinase-2 and tissue inhibitor of matrix metalloproteinase-2 contributes to the development of early diabetic nephropathy [PDF]

Nephrology Dialysis Transplantation, 2006
High glucose and angiotensin-II (Ang-II) levels are the known important mediators of diabetic nephropathy. However, the effects of these mediators on matrix metalloproteinase-2 (MMP-2) and on tissue inhibitor of metalloproteinase-2 (TIMP-2) in proximal tubule cells have yet to be fully examined within the context of early stage diabetic nephropathy.In ...
Sang Youb, Han, Yi Hwa, Jee, Kum Hyun, Han, Young Sun, Kang, Hyoung Kyu, Kim, Jee Young, Han, Young Sik, Kim, Dae Ryong, Cha   +7 more
openaire   +2 more sources

Role of Oxidative Stress and Genetic Polymorphism of Matrix Metalloproteinase-2 and Tissue Inhibitor of Metalloproteinase-2 in COPD

Chronic Obstructive Pulmonary Diseases: Journal of the COPD Foundation, 2023
Article in press withdrawn by publisher.
Poonam, Sangwan, Huma, Quasimi, Jai Gopal, Sharma, Mohammad Anwar, Habib, Mohammad Iqbal, Alam   +4 more
openaire   +2 more sources

The effects of a plant proteinase inhibitor from Enterolobium contortisiliquum on human tumor cell lines [PDF]

, 2011
Supplementary to the efficient inhibition of trypsin, chymotrypsin, plasma kallikrein, and plasmin already described by the EcTI inhibitor from Enterolobium contortisiliquum, it also blocks human neutrophil elastase (K(iapp)=4.3 nM) and prevents phorbol ...
Sampaio, Misako U. [UNIFESP], Oliva, Maria Luiza V. [UNIFESP], Maria Luiza V. Oliva, Mayer, Barbara, Neth, Peter, Andrade de Paula, Claudia Alessandra [UNIFESP], Sampaio, Misako U., Nakahata, Adriana Miti [UNIFESP], Christian Ries, Adriana Miti Nakahata, Andrade de Paula, Claudia Alessandra, Karow, Marisa, Barbara Mayer, Cláudia Alessandra Andrade de Paula, Marisa Karow, Marianne Jochum, Oliva, Maria Luiza V., Jochum, Marianne, Misako U. Sampaio, Ries, Christian, Nakahata, Adriana Miti, Peter Neth   +21 more
core   +1 more source

Relationships between markers of extracellular matrix degradation and systemic inflammatory response among patients with acute myocardial infarction

Сучасні медичні технології, 2020
Despite all the preventive, diagnostic and therapeutic possibilities of our time, diseases of the circulatory system are the leading causes of death among adult population both in the world and in Ukraine.
E. V. Sid, V. V. Litvinenko
doaj   +1 more source

Serum matrix metalloproteinase 2 and tissue inhibitor of matrix metalloproteinases 2 in esophageal cancer patients

Folia Histochemica et Cytobiologica, 2012
The positive expression of MMP-2 and TIMP-2 were found in esophageal cancer (EC) tissue and correlated with cancer stage and clinico-pathological features of tumor and patients' survival. However, little is known about serum levels of those proteins in EC patients. The aim of the present study was to investigate the diagnostic significance of MMP-2 and
Magdalena, Groblewska, Barbara, Mroczko, Miroslaw, Kozlowski, Jacek, Niklinski, Jerzy, Laudanski, Maciej, Szmitkowski   +5 more
openaire   +3 more sources