Results 81 to 90 of about 166,368,995 (207)

The Impact of Differential Expression of Extracellular Matrix Metalloproteinase Inducer, Matrix Metalloproteinase-2, Tissue Inhibitor of Matrix Metalloproteinase-2 and PDGF-AA on the Chronicity of Venous Leg Ulcers [PDF]

European Journal of Vascular and Endovascular Surgery, 2006
Introduction. Alteration in the expression of extracellular matrix metalloproteinase inducer (EMMPRIN), matrix metalloproteinase-2 (MMP-2), tissue inhibitors of matrix metalloproteinases (TIMP-2) and platelet derived growth factor (PDGF-AA) may contribute to poor healing in venous leg ulcers. Aim. The aim of this study is to determine the expression of
Mwaura, B., Mahendran, B., Hynes, N., Defreitas, D., Avalos, G., Adegbola, T., Adham, M., Connolly, C.E., Sultan, S.   +8 more
openaire   +3 more sources

Inhibition of Trophoblast-Induced Spiral Artery Remodeling Reduces Placental Perfusion in Rat Pregnancy. [PDF]

, 2010
Rats harboring the human angiotensinogen and human renin genes develop preeclamptic features in pregnancy. The preeclamptic rats exhibit a deeper trophoblast invasion associated with a reduced resistance index by uterine Doppler.
Muller, DN, Cartwright, JE, Pijnenborg, R, Pijnenborg, R., Stefan Verlohren, Luft, F.C., Mueller, D.N., Lydia Hering, Morton, J., Davidge, ST, Dechend, R, Geusens, N, Robert Pijnenborg, Herse, F, Judith E. Cartwright, Herse, F., Florian Herse, Ralf Dechend, Dudenhausen, J.W., Nele Geusens, Cartwright, J.E., Geusens, N., Verhaegen, I., Jude Morton, Morton, J, Hering, L, Iris Verhaegen, Dominik N. Muller, Dechend, R., Sandra T. Davidge, Joachim W. Dudenhausen, Hering, L., Davidge, S.T., Verlohren, S, Verhaegen, I, Dudenhausen, JW, Friedrich C. Luft, Verlohren, S., Luft, FC   +38 more
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Hydroxysafflor Yellow A Suppresses MRC-5 Cell Activation Induced by TGF-β1 by Blocking TGF-β1 Binding to TβRII

Frontiers in Pharmacology, 2017
Hydroxysafflor yellow A (HSYA) is an active ingredient of Carthamus tinctorius L.. This study aimed to evaluate the effects of HSYA on transforming growth factor-β1 (TGF-β1)-induced changes in proliferation, migration, differentiation, and extracellular ...
Ruiyan Pan, Yadan Zhang, Meng Zheng, Baoxia Zang, Ming Jin   +4 more
doaj   +1 more source

NDRG2 ameliorates hepatic fibrosis by inhibiting the TGF-β1/Smad pathway and altering the MMP2/TIMP2 ratio in rats. [PDF]

PLoS ONE, 2011
Liver fibrosis is a worldwide clinical issue. It has been well established that activated hepatic stellate cells (HSCs) are responsible for excessive extracellular matrix (ECM) deposition in chronically damaged livers.
Jiandong Yang, Jin Zheng, Lin Wu, Ming Shi, Hongtao Zhang, Xing Wang, Ning Xia, Desheng Wang, Xinping Liu, Libo Yao, Yan Li, Kefeng Dou   +11 more
doaj   +1 more source

Interdependence of kallikrein-related peptidases in proteolytic networks [PDF]

, 2010
Human kallikrein-related peptidases (KLKs) are 15 homologous serine proteases involved in several (patho)physiological processes, including cancer. Secreted as precursors, they are activated upon proteolytic release of a short propeptide. We searched for
Burkhart, Julia M., Schwarz, Amelie, Christian Ries, Utzschneider, Daniel, Karolina Plaza, Debela, M., Amelie Schwarz, Plaza, Karolina, Beaufort, Nathalie, Creutzburg, Sabine, Ries, C., Schmitt, M., Burkhart, J. M., Beaufort, N., Plaza, K., Ries, Christian, Schwarz, A., Sabine Creutzburg, Mekdes Debela, Creutzburg, S., Schmitt, Manfred, Utzschneider, D., Julia M. Burkhart, Magdolen, Viktor, Debela, Mekdes, Viktor Magdolen, Nathalie Beaufort, Magdolen, V., Beaufort, N;Plaza, K;Utzschneider, D;Schwarz, A;Burkhart, JM;Creutzburg, S;Debela, M;Schmitt, M;Ries, C;Magdolen, V   +28 more
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Metalloproteinase and tissue inhibitor of metalloproteinase in tuberculosis and malignant pleural effusion

Egyptian Journal of Chest Disease and Tuberculosis, 2013
Pleural effusions are associated with a number of medical conditions causing fluid accumulation via differing synergistic mechanisms including increased pleural membrane permeability, increased pulmonary capillary pressure, decreased oncotic pleural ...
Nesriene Mohamad El Margoushy, Amany Todary Khaleel   +1 more
doaj   +1 more source

Correlations between papillary thyroid cancer and peripheral blood levels of matrix metalloproteinase-2, matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1, and tissue inhibitor of metalloproteinase-2

Chinese Medical Journal, 2013
Background The relationship between the presence of metalloproteinases and thyroid cancer remains unknown, and many controversies still exist in this field. The objective of this study was to investigate the correlations between papillary thyroid cancer and peripheral blood levels of matrix metalloproteinase-2, matrix ...
Shao-Fei, Zhou, San-Yuan, Hu, Lei, Ma, Lei, Miao, Wei-Zheng, Mao   +4 more
openaire   +2 more sources

Prospective study of matrix metalloproteinase-9 and risk of myocardial infarction and stroke in older men and women [PDF]

, 2009
OBJECTIVES: The endopeptidase matrix metalloproteinase-9 (MMP-9) is implicated in atherosclerotic plaque rupture. We investigate prospective associations between MMP-9 and MI or stroke in an older general population cohort, accounting for established and
Lowe, Gordon, Welsh, P, Thomson, A., Jefferis, B. J., Lennon, L., Lowe, G., Ebrahim, S, Carson, Claire, Jefferis, B.J., Welsh, Paul, Rumley, A., Ebrahim, S., Ebrahim, Shah, Jefferis, Barbara J, Lawlor, Debbie, Jefferis, BJ, Welsh, P., Whincup, Peter, Wannamethee, G, Lawlor, D., Lawlor, D, Wannamethee, G., Rumley, Ann, Whincup, P., Whincup, P, Thomson, Andy, Jefferis, Barbara J., Thomson, A, Lennon, Lucy, Wannamethee, Goya, Carson, C., Rumley, A, Lennon, L, Carson, C, Lowe, G   +34 more
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Urinary matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 1 biomarkers for predicting renal scar in children with urinary tract infection

Urology Research and Practice, 2019
Objective: Urinary tract infection occurs in 1.8–6.6% of children under 6 years old. The aim of this study was to assess the urinary concentrations of matrix metalloproteinase 9 (MMP9) and tissue inhibitor of metalloproteinase 1 (TIMP1), in children with
Seyed Mohammad Abedi, Hamid Mohammadjafari, Alireza Rafiei, Sara Bazi, Pooneh Yazdani   +4 more
doaj   +1 more source

Expression of Tissue Inhibitor of Matrix Metalloproteinases-2 in Healthy Oral Mucosa

Стоматология. Эстетика. Инновации, 2021
Цель. Оценить характер экспрессии тканевого ингибитора матриксных металлопротеиназ-2 (ТИМП-2) в биоптатах здоровой слизистой оболочки полости рта.Материалы и методы. Забор биопсийного материала был выполнен у 30 пациентов. Биоптаты здоровой слизистой оболочки были получены во время дентальной имплантации.Результаты.
openaire   +1 more source