Results 101 to 110 of about 83,548 (314)

Manipulation of Wnt/β‐Catenin Signaling by Synthetic Frizzled Agonist and LRP Antagonist in Organoid Cultures and In Vivo

Small Methods, EarlyView.
Harnessing synthetic key receptor modulators, this study presents a breakthrough in Wnt/β‐catenin regulation. The FZD agonist RRP‐pbFn bypasses LRP5/6 to drive organoid expansion and tissue regeneration, while the LRP antagonist RRP‐Dkk1c eradicates tumors. These tools enable precise pathway control, advancing regenerative and cancer therapies.
Quanhui Dai, Jiawen Wang, Zihuan Lin, Danni Yu, Hui Yang, Jinsong Wei, Xiaoyu Li, Hao Hu, Chao Ni, Bing Zhao   +9 more
wiley   +1 more source

Platelet and vascular function during coronary thrombolysis with tissue-type plasminogen activator. [PDF]

, 1989
David Kerins, L. Le Roy, Garret A. FitzGerald, Desmond J. Fitzgerald   +3 more
openalex   +1 more source

Brain metastasis in non‐small cell lung cancer: High‐risk factors and predictive models

VIEW, EarlyView.
Artificial intelligence (AI) can integrate of data to predict brain metastases (BM) in non‐small cell lung cancer (NSCLC). AI algorithms are employed to analyze these multifaceted datasets, enabling the identification of complex patterns and correlations that may not be apparent through traditional analytical methods.
Chen Gong, Ben Zhao, Shuangshuang Mao, Qingxu Liu, Yuanyuan Zhao, Yiwen Liu, Yao Luo, Qianxia Li   +7 more
wiley   +1 more source

Elevated plasminogen activators are associated with hematoma progression in spontaneous intracerebral hemorrhage

Brain Hemorrhages, 2020
Endogenous fibrinolysis might lead to hematoma progression in spontaneous intracerebral hemorrhage (ICH). We studied plasma biomarkers of fibrinolysis and hemostasis in twenty-two patients with ICH and nine healthy controls (HC) in a single-center study.
Zhe Kang Law, Michael Desborough, Kamini Rakkar, Philip M. Bath, Ulvi Bayraktutan, Nikola Sprigg   +5 more
doaj  

Thrombolysis in Stroke Patients; Problems and Limitations [PDF]

Iranian Journal of Medical Sciences, 2010
Thrombolysis for stroke is being used in some developingcountries. This study was designed to evaluate the problems ofthrombolysis therapy in Iran. During January-July 2008, all patientswith ischemic stroke admitted to Ghaem Hospital, Mashhad,northeast ...
Kavian Ghandehari,, Mohsen Foroughipour, Ali Pourzahed, Marzieh Taheri, Maryam Abbasi, Shirin Gorjestani, Amir Moghaddam Ahmadi, Mohammad Ali Nahayati   +7 more
doaj  

Quercetin Reduces Vascular Senescence and Inflammation in Symptomatic Male but Not Female Coronary Artery Disease Patients

Aging Cell, EarlyView.
In male patients undergoing CABG surgery, pretreatment with quercetin suppressed inflammaging and its associated inflammation, leading to improved endothelium‐dependent relaxation (measured ex vivo) and reducing new onset of post‐operative atrial fibrillation.
Pauline Mury, Olina Dagher, Annik Fortier, Ariel Diaz, Yoan Lamarche, Pierre‐Emmanuel Noly, Marina Ibrahim, Pierre Pagé, Philippe Demers, Denis Bouchard, Pierre‐Luc Bernier, Nancy Poirier, Emmanuel Moss, Nicolas Durrleman, Hughes Jeanmart, Michel Pellerin, Guillaume Lettre, Nathalie Thorin‐Trescases, Michel Carrier, Eric Thorin   +19 more
wiley   +1 more source

FRACTIONATION OF PLASMINOGEN ACTIVATOR AND PROACTIVATOR IN TISSUE AND BLOOD BY GEL FILTRATION

, 1964
Akikazu Takada, Yumiko Takada, U Okamoto
openalex   +2 more sources

Catabolism of human tissue plasminogen activator in mice [PDF]

, 1985
HE Fuchs, H Jr Berger, SV Pizzo
openalex   +1 more source

Intermittent Supplementation With Fisetin Improves Physical Function and Decreases Cellular Senescence in Skeletal Muscle With Aging: A Comparison to Genetic Clearance of Senescent Cells and Synthetic Senolytic Approaches

Aging Cell, EarlyView.
Supplementation with the natural senolytic agent fisetin attenuated age‐related declines in physical function in mice. Better physical function with fisetin was accompanied by lower expression of cell senescence‐related genes. Fisetin treatment had comparable effects on physical function as genetic clearance of senescent cells and synthetic senolytic ...
Kevin O. Murray, Sophia A. Mahoney, Katelyn R. Ludwig, Jill H. Miyamoto‐Ditmon, Nicholas S. VanDongen, Nirad Banskota, Allison B. Herman, Douglas R. Seals, Robert T. Mankowski, Matthew J. Rossman, Zachary S. Clayton   +10 more
wiley   +1 more source

Ultrasound-targeted transfection of tissue-type plasminogen activator gene carried by albumin nanoparticles to dog myocardium to prevent thrombosis after heart mechanical valve replacement

International Journal of Nanomedicine, 2012
Ji Jun, Ji Shang-Yi, Yang Jian-An, He Xia, Yang Xiao-Han, Ling Wen-Ping, Chen Xiao-LingDepartment of Pathology and Cardiovascular Surgery, Shenzhen Sun Yat-Sen Cardiovascular Hospital, Shenzhen, Guangdong, People's Republic of ChinaBackground ...
Ji J, Ji S-Y, Yang J-A, He X, Yang X-H, Ling W-P, Chen X-L   +6 more
doaj