Results 111 to 120 of about 156,767 (359)

Angiogenesis as a Therapeutic Target of (Poly)phenols: Tackling Cancer and Vascular‐Related Complications

open access: yesMolecular Nutrition &Food Research, EarlyView.
(Poly)phenols constitute a source of natural therapeutic molecules capable of targeting angiogenesis in different scenarios. This review summarizes the current evidence of the role of (poly)phenols in modulating angiogenesis. The reader can find a compilation of preclinical and human investigations describing pro‐ and anti‐angiogenic effects of these ...
María Ángeles Ávila‐Gálvez   +5 more
wiley   +1 more source

Intravenous Thrombolysis, Time Window, Dosage, and Off-Label

open access: yesCaspian Journal of Neurological Sciences, 2018
Despite the development of Intravenous thrombolysis with tissue Plasminogen Activator (IVtPA) guidelines in each affiliated stroke center, protocol violations may be observed in each hospital with IVtPA facilities.
Kavian Ghandehari   +6 more
doaj  

Oscillating gradient spin echo diffusion time effects implicate variations in neurite beading for the heterogeneous reduced diffusion in human acute ischemic stroke lesions

open access: yesMagnetic Resonance in Medicine, EarlyView.
Abstract Purpose Monte Carlo simulations and short diffusion time measurements have suggested neurite beading and swelling as the underlying mechanism of reduced diffusion in acute stroke, although the observed diffusion time dependence is often heterogeneous and not yet fully understood.
Mi Zhou   +11 more
wiley   +1 more source

The Ly49E receptor inhibits the immune control of acute Trypanosoma cruzi infection [PDF]

open access: yes, 2016
The protozoan parasite Trypanosoma cruzi circulates in the blood upon infection and invades various cells. Parasites intensively multiply during the acute phase of infection and persist lifelong at low levels in tissues and blood during the chronic phase.
Almeida   +48 more
core   +2 more sources

A comprehensive review on adaptive plasticity and recovery mechanisms post‐acquired brain injury

open access: yesNeuroprotection, EarlyView.
This figure illustrates the dynamic process of neurogenesis following brain injury, focusing on the roles of neural stem and progenitor cells at the injury site. Key mechanisms include axonal sprouting, synaptogenesis, dendritic remodeling, and brain‐derived neurotrophic factor signaling via TrkB receptors.
Ravi Kumar Rajan
wiley   +1 more source

The NLRP3 inhibitor NT‐0796 enhances and sustains GLP‐1R agonist‐mediated weight loss in a murine diet‐induced obesity model

open access: yesObesity, EarlyView.
In mouse diet‐induced obesity models, the brain penetrant NLRP3 inhibitor NT‐0796 enhances and sustains the efficacy of the GLP‐1RA semaglutide, leading to a complete reversal of obesity. This correlates with reduced peripheral inflammation and anti‐neuroinflammatory activities, including a reduction in hypothalamic gliosis suggesting further benefits ...
Peter Thornton   +6 more
wiley   +1 more source

Human tissue-type plasminogen activator

open access: yesThrombosis and Haemostasis, 2014
SummaryTissue-type plasminogen activator (t-PA ) plays an important role in the removal of intravascular fibrin deposits and has several physiological roles and pathological activities in the brain. Its production by many other cell types suggests that t-PA has additional functions outside the vascular and central nervous system.
Sylvie Dunoyer-Geindre   +1 more
openaire   +4 more sources

Reducing Surgery for Pediatric Posttonsillectomy Hemorrhage Using Tranexamic Acid: A Quality Improvement Initiative

open access: yesOtolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective Evaluate the use of tranexamic acid (TXA) and observation as a management option for pediatric patients presenting with posttonsillectomy hemorrhage (PTH). Study Design Retrospective analysis of a prospectively implemented quality improvement initiative with a historical control comparison group. Setting Tertiary children's hospital.
Laura A. Petrauskas   +12 more
wiley   +1 more source

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