Results 121 to 130 of about 599,368 (371)
Human Tissue Plasminogen Activator [PDF]
, 2000 Tissue plasminogen activator (tPA) has long been considered the flagship product of the biotechnology industry. This protein is a popular treatment for heart attacks, coronary heart disease, and stroke.
Audette, Melissa +2 more
core +1 more source
Early increases in plasminogen activator activity following partial hepatectomy in humans [PDF]
, 2004 Background Increases in urokinase-like plasminogen activator (uPA) activity are reported to be amongst the earliest events occurring in remnant liver following partial hepatectomy in rats, and have been proposed as a key component of the regenerative ...
Bird, N.C. +3 more
core +2 more sources
Annals of Neurology, EarlyView.Objectives Intravenous thrombolysis (IVT) is contraindicated for acute ischemic stroke (AIS) patients taking direct oral anticoagulants (DOACs) within 48 hours before index stroke. Limited data exist on off‐label use of IVT for these patients. We compared the safety and outcomes of IVT in AIS patients with DOAC treatment and patients with no OAC before
Marius Matusevicius +11 more
wiley +1 more source
Erythrocyte-Inspired Discoidal Polymeric Nanoconstructs carrying Tissue Plasminogen Activator for the Enhanced Lysis of Blood Clots [PDF]
arXiv, 2019 Tissue plasminogen activator (tPA) is the sole approved therapeutic molecule for the treatment of acute ischemic stroke. Yet, only a small percentage of patients could benefit from this life-saving treatment because of medical contraindications and severe side effects, including brain hemorrhage, associated with delayed administration.
arxiv
Systemic effects of tissue plasminogen activator-associated fibrinolysis and its relation to thrombin generation in orthotopic liver transplantation [PDF]
, 1989 Orthotopic liver transplantation is frequently associated with hyperfibrinolysis, the origin and clinical relevance of which is largely unknown. In 20 orthotopic liver transplantations, we studied the occurrence and systemic effects of hyperfibrinolysis.
Bontempo, FA +5 more
core +1 more source
Journal of Diabetes, Volume 14, Issue 12, Page 806-814, December 2022., 2022 Highlights Metformin activates GDF15 expression, which reduces appetite with induction of weight loss in both diabetic and non‐diabetic patients. GDF15 level is linked and correlated with the progression of diabetic complications including thrombosis, diabetic nephropathy, diabetic neuropathy, and diabetic retinopathy. Abstract Type 2 diabetes mellitus
Hayder M. Al‐kuraishy +8 more
wiley +1 more source
Numerical study of cancer cell invasion dynamics using adaptive mesh refinement: the urokinase model [PDF]
arXiv, 2014 In the present work we investigate the chemotactically and proteolytically driven tissue invasion by cancer cells. The model employed is a system of advection-reaction-diffusion equations that features the role of the serine protease urokinase-type plasminogen activator.
arxiv
Basic &Clinical Pharmacology &Toxicology, Volume 132, Issue 1, Page 83-97, January 2023., 2023 Abstract Exposure to fine particulate matter (PM2.5) from incomplete fossil fuel combustion (coal, oil, gas and diesel) has been linked to increased morbidity and mortality due to metabolic diseases. PM2.5 exaggerate adipose inflammation and insulin resistance in mice with diet‐induced obesity.
Bendik C. Brinchmann +9 more
wiley +1 more source
Theory of mechano-chemical patterning in biphasic biological tissues [PDF]
, 2018 The formation of self-organized patterns is key to the morphogenesis of multicellular organisms, although a comprehensive theory of biological pattern formation is still lacking. Here, we propose a minimal model combining tissue mechanics to morphogen turnover and transport in order to explore new routes to patterning.
arxiv +1 more source
New England Journal of Medicine, 1997 BACKGROUND Among physicians who treat patients with acute myocardial infarction, there is controversy about the magnitude of the clinical benefit of primary (i.e., immediate) coronary angioplasty as compared with thrombolytic therapy.
M. Simoons, S. Ellis
semanticscholar +1 more source