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Tissue Activator of Plasminogen
Nature, 1964SINCE Astrup and Permin1 reported that animal tissue cells contain an activator of plasminogen, various authors have confirmed their results, and comparisons of the activator content of different human2 and animal tissues3,4 have been published. Most authors have used whole tissue or aqueous tissue extracts and have estimated activity by the fibrin ...
Charles H. Lack, S. Yousuf Ali
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New England Journal of Medicine, 1988
TISSUE plasminogen activator (t-PA) is a naturally occurring protein that catalyzes the conversion of the inactive proenzyme plasminogen into the active serine protease plasmin.
John A. Oates +3 more
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TISSUE plasminogen activator (t-PA) is a naturally occurring protein that catalyzes the conversion of the inactive proenzyme plasminogen into the active serine protease plasmin.
John A. Oates +3 more
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Plasminogen activation by tissue plasminogen activator in the presence of platelets
Thrombosis Research, 1988Platelets were found to provide a surface for activation of plasminogen by the tissue-type plasminogen activator (t-PA) at an optimum concentration and to potentiate the generation of plasmin by the amidolytic method, fibrin lysis time and fibrin plate method.
Katsumi Deguchi, Shigeru Shirakawa
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Activation of Bovine Plasminogen by the Plasminogen Activator in Animal Tissue
Thrombosis and Haemostasis, 1960Summary1. The activation of bovine plasminogen by means of the plasminogen activator from pig heart tissue has been studied on heated fibrin and on casein.2. Small, but varying, amounts of activator can be extracted from crude activator powder during the experiment and interfere therefore with estimations on normal, plasminogen containing fibrin.3. The
Takeshi Abe, Tage Astrup
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Tissue Plasminogen Activator (t-PA)
Therapeutic Drug Monitoring, 1993Tissue plasminogen activator (t-PA) developed from recombinant DNA technology is a highly effective thrombolytic agent. Its main clinical application is in the treatment of acute myocardial infarction (MI), with most beneficial results occurring in patients treated early after the onset of symptoms. When t-PA was compared with other thrombolytic agents,
Jayesh Madhani +2 more
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The Plasminogen Activator in Animal Tissue
Acta Physiologica Scandinavica, 1956Summary.1. The plasminogen activator in pig heart tissue and pig lung tissue has been isolated in soluble form and partially purified.2. The tissue activator is a fairly thermostable substance especially at acid reaction.3. The tissue activator represents a type of plasminogen activator different from the activator found in urine or produced in blood ...
Tage Astrup, Ida Sterndorff
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The potentiating effect of platelet on plasminogen activation by tissue plasminogen activator
Thrombosis Research, 1985A new role for platelets in fibrinolysis is proposed. Platelets (euglobulin from platelet rich plasma and from human platelet extract) may potentiate plasminogen activation by tissue plasminogen activator (tPA). The potentiating activity was detected by both chromogenic substrate and fibrin plate analysis. The fibrinolysis-potentiating substance in the
F. W. Dunn +6 more
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European Journal of Clinical Pharmacology, 1992
Defibrotide, a polydeoxyribonucleotide of mammalian origin, has been shown to reduce the blood level of the plasminogen activator inhibitor, and so to increase the activity of tissue plasminogen activator without any adverse effect. A randomized, double-blind, placebo-controlled study has been done in 22 patients, 14 with peripheral vascular disease, 6
VIOLI, Francesco +5 more
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Defibrotide, a polydeoxyribonucleotide of mammalian origin, has been shown to reduce the blood level of the plasminogen activator inhibitor, and so to increase the activity of tissue plasminogen activator without any adverse effect. A randomized, double-blind, placebo-controlled study has been done in 22 patients, 14 with peripheral vascular disease, 6
VIOLI, Francesco +5 more
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Differences in the activation rates of plasminogen by tissue plasminogen activator and urokinase
Thrombosis Research, 1987The activation of a native form of plasminogen (Glu-plg) by tissue plasminogen activator(t-PA) was enhanced when the plasma was clotted by the addition of thrombin or thrombin plus Ca++. Cross-linking of fibrin in the clotted plasma did not inhibit the fibrin-associated enhancement of the activation of plasminogen by t-PA.
Masaru Cho +3 more
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