Results 111 to 120 of about 489,905 (329)

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

A custom preservation solution extends the ex vivo availability of living heart valves for transplantationCentral MessagePerspective

JTCVS Open
Objectives: Although heart valve transplantation delivers living, growth-capable valves, its clinical implementation is restricted by transplant logistics and donor availability.
Elizabeth M. Cordoves, BA, Baoqi Liu, MS, Olivier Pont, BS, V. Reed LaSala, MD, Griffin Welsh Daly, BS, Keith Yeager, MS, Lucie Chicaud, BS, Richard Zhuang, MS, Senay Ustunel, PhD, Kavya Rajesh, MD, Nicole Julia, Sophia Jackman, MD, Sharon Fleischer, PhD, Emile A. Bacha, MD, Emmanuel Zorn, PhD, Giovanni Ferrari, PhD, Gordana Vunjak-Novakovic, PhD, David M. Kalfa, MD, PhD   +17 more
doaj   +1 more source

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

3-Dimensional Volumetric Analysis of Double Socket-shield for Maximum Tissue Preservation at Immediate Implant Replacement of Multi-Rooted Teeth, A Case Report [PDF]

, 2018
Maher Abdullatif Walid
openalex   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Surgical Aspects of Ovarian Tissue Removal and Ovarian Tissue Transplantation for Fertility Preservation [PDF]

, 2016
M.W. Beckmann, Ralf Dittrich, Sebastian Findeklee, Laura Lotz   +3 more
openalex   +1 more source

Improved preservation of ovarian tissue morphology that is compatible with antigen detection using a fixative mixture of formalin and acetic acid [PDF]

, 2021
Babatomisin V. Adeniran, Bríet Bjarkadóttir, Ruth Appeltant, Sheila Lane, Suzannah A. Williams   +4 more
openalex   +1 more source

The implementation of persuasive technology principles in mobile application development: a qualitative study [PDF]

, 2017
Preceding studies of persuasive technology have mentioned several benefits on the implementation of persuasive design features of the Persuasive System Design (PSD) model such as creating users' engagement and acceptance and continuous usage.
Shafin, Noor Afifah
core  

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Use of intraoperative ultrasound in resection of early-stage borderline ovarian tumors: A case series

Gynecologic Oncology Reports
Borderline ovarian tumors (BOTs) commonly occur in women of reproductive age. For patients desiring fertility preservation, cystectomies are recommended as healthy ovarian tissue is spared.
Karthiga Natarajan, Marilyn Boo, Samir A. Saidi   +2 more
doaj   +1 more source