Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis
FEBS Open Bio, EarlyView.Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho +4 more
wiley +1 more source
Exceptional soft tissue preservation reveals a cnidarian affinity for a Cambrian phosphatic tubicolous enigma. [PDF]
Proc Biol Sci, 2022 Zhang G, Parry LA, Vinther J, Ma X.
europepmc +1 more source
YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
A Technical Note of Improvement of the Elnady Technique for Tissue Preservation in Veterinary Anatomy. [PDF]
Animals (Basel), 2022 Bernal V +4 more
europepmc +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Periodontal granulation tissue preservation in surgical periodontal disease treatment: a pilot prospective cohort study. [PDF]
J Periodontal Implant Sci, 2022 Moreno Rodríguez JA, Ortiz Ruiz AJ.
europepmc +1 more source
FEBS Open Bio, EarlyView.Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin +3 more
wiley +1 more source
Fertility preservation in patients with ovarian tumours − a single centre experience
Gynecologic Oncology ReportsObjective: A report of the 15 years’-experience in fertility preservation in women with ovarian tumours, at the Fertility Preservation Centre of the Unidade Local de Saúde Coimbra, the only Centre in Portugal performing fertility preservation techniques ...
Alexandra Almeida-Santos +2 more
doaj +1 more source
A Minimalistic Technique for Neural Tissue Preservation and Neuroanatomical Education: Quantitative Study of the Elnady Technique on Human Cadaveric Specimens. [PDF]
Cureus, 2022 Reihl S +5 more
europepmc +1 more source
FEBS Open Bio, EarlyView.KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura +19 more
wiley +1 more source