Results 91 to 100 of about 495,630 (303)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Biopreservation of hepatocytes: current concepts on hypothermic preservation, cryopreservation, and vitrification [PDF]

, 2013
Isolated liver cells (primarily isolated hepatocytes) have found important applications in science and medicine over the past 40 years in a wide range of areas, including physiological studies, investigations on liver metabolism, organ preservation and ...
Balaban, Cecilia Lucía, Fuller, Barry J., Guibert, Edgardo Elvio, Petrenko, Alexander Y., Rodriguez, Joaquin Valentin, Somov, Alexander Y.   +5 more
core  

Principles of Pituitary Surgery [PDF]

, 2018
Key Points 1. Understand the principles of pituitary surgery including the key-elements of surgical planning and decision-making 2. Identify the technical nuances distinguishing the endoscopic from the microscopic transsphenoidal approach 3.
Evans, James J., Farag, MD, Alexander, Farrell, MD, Christopher J, Nyquist, MD, Gurston G., Rosen, Marc, MD   +4 more
core   +2 more sources

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

A custom preservation solution extends the ex vivo availability of living heart valves for transplantationCentral MessagePerspective

JTCVS Open
Objectives: Although heart valve transplantation delivers living, growth-capable valves, its clinical implementation is restricted by transplant logistics and donor availability.
Elizabeth M. Cordoves, BA, Baoqi Liu, MS, Olivier Pont, BS, V. Reed LaSala, MD, Griffin Welsh Daly, BS, Keith Yeager, MS, Lucie Chicaud, BS, Richard Zhuang, MS, Senay Ustunel, PhD, Kavya Rajesh, MD, Nicole Julia, Sophia Jackman, MD, Sharon Fleischer, PhD, Emile A. Bacha, MD, Emmanuel Zorn, PhD, Giovanni Ferrari, PhD, Gordana Vunjak-Novakovic, PhD, David M. Kalfa, MD, PhD   +17 more
doaj   +1 more source

Texture profile analysis reveals a stiffer ovarian cortex after testosterone therapy : a pilot study [PDF]

, 2019
Purpose: The importance of the surrounding ovarian stromal cells and extracellular matrix in the development and maturation of follicles has recently gained attention.
De Roo, Chloë, De Sutter, Petra, Declercq, Heidi, T'Sjoen, Guy, Tilleman, Kelly, Vercruysse, Chris, Weyers, Steven   +6 more
core   +2 more sources

Insights into a long life without cancer: The case of the bowhead whale

Molecular Oncology, EarlyView.
Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Optimization of ultrastructural preservation of human brain for transmission electron microscopy after long post-mortem intervals

Acta Neuropathologica Communications, 2019
Electron microscopy (EM) provides the necessary resolution to visualize the finer structures of nervous tissue morphology, which is important to understand healthy and pathological conditions in the brain.
Mariella Sele, Stefan Wernitznig, Saška Lipovšek, Snježana Radulović, Johannes Haybaeck, Anna Maria Birkl-Toeglhofer, Christina Wodlej, Florian Kleinegger, Stephan Sygulla, Marlene Leoni, Stefan Ropele, Gerd Leitinger   +11 more
doaj   +1 more source