Results 81 to 90 of about 495,630 (303)

Preservation Of Living Tissue Of Young Permanent Teeth

International Dental Journal
Introduction: The child reported spontaneous pain in the right lower posterior teeth for three days,and had a towering tooth tip broken to seek treatment.
Qiao Wang
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Freezing and chemical preservatives alter the stable isotope values of carbon and nitrogen of the Asiatic clam (Corbicula fluminea) [PDF]

, 2011
We tested the impacts of most common sample preservation methods used for aquatic sample materials on the stable isotope ratios of carbon and nitrogen in clams, a typical baseline indicator organism for many aquatic food web studies utilising stable ...
Aurélia Martino, B Fry, B Kelly, BJ Peterson, CJ Sweeting, DM Post, Dorothée Kopp, Frédéric Santoul, H Feuchtmayr, HC Sarakinos, J Dannheim, J Syväranta, J Syväranta, Jari Syväranta, KL Bosley, LM Barrow, M Ventura, MM Mullin, MS Edwards, NO Ogawa, Régis Céréghino, S Carabel, S Kaehler   +22 more
core   +5 more sources

Silurian brachiopods with soft-tissue preservation

Nature, 2005
'Articulated' rhynchonelliformean brachiopods are abundant shelly fossils, but the direct fossil record of their soft parts was hitherto confined to a single pyritized trace possibly representing a lophophore. Anatomical knowledge of extinct rhynchonelliformeans relies heavily on analogies to extant species; these analogies are untested for stem-group ...
Sutton, MD, Briggs, D, Siveter, D, Siveter, D   +3 more
openaire   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Evaluating ultrastructural preservation quality in banked brain tissue

Free Neuropathology
The ultrastructural analysis of postmortem brain tissue can provide important insights into cellular architecture and disease-related changes. For example, connectomics studies offer a powerful emerging approach for understanding neural circuit ...
Macy Garrood, Alicia Keberle, Allison Sowa, William Janssen, Emma Thorn, Claudia De Sanctis, Kurt Farrell, John Crary, Andrew McKenzie   +8 more
doaj   +1 more source

Large-scale associations between the leukocyte transcriptome and BOLD responses to speech differ in autism early language outcome subtypes. [PDF]

, 2018
Heterogeneity in early language development in autism spectrum disorder (ASD) is clinically important and may reflect neurobiologically distinct subtypes.
A Battle, A Krishnan, A Perry, A Schroeder, A Sugathan, A Venter, AJ Willsey, AM Wetherby, AR McIntosh, AR Pfenning, AT Hilliard, BS Abrahams, C Demopoulos, C Lord, CR Genovese, Cynthia Carter Barnes, DA Rossignol, DH Geschwind, DH Geschwind, DL Vargas, E Redcay, E Redcay, EA Boyle, EJ Greenblatt, Eric Courchesne, F Happé, G Dehaene-Lambertz, G Hickok, G Konopka, G Konopka, H Tager-Flusberg, HR Cremers, I Voineagu, J Cotney, JA Kosmicki, JA Miller, JC Darnell, JD Storey, JI Berman, JT Morgan, K Gotham, K Pierce, K Pierce, K Pierce, Karen Pierce, L Hippolyte, Linda Lopez, Lisa Eyler, LT Eyler, M Chikina, M Lek, MC Lai, MC Oldham, MCN Marchetto, ME Ritchie, Michael V. Lombardo, MM Kjelgaard, MV Lombardo, Nathan E. Lewis, NN Parikshak, NN Parikshak, NR Wray, P Du, P Howlin, P Langfelder, P Langfelder, P Szatmari, R Bernier, RC Gentleman, Richard A. I. Bethlehem, RJ Kelleher III, S Kapur, S Rubeis De, S Sandin, SJ Sanders, T Pramparo, T Pramparo, T Yarkoni, Tiziano Pramparo, Vahid Gazestani, Varun Warrier, X Liu, X Nuttle   +82 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Fossilized skin reveals coevolution with feathers and metabolism in feathered dinosaurs and early birds [PDF]

, 2018
Feathers are remarkable evolutionary innovations that are associated with complex adaptations of the skin in modern birds. Fossilised feathers in non-avian dinosaurs and basal birds provide insights into feather evolution, but how associated ...
Benton, Michael J., Foley, Tara, Hone, David W. E., Johnson, Diane, Kearns, Stuart L., McNamara, Maria E., Orr, Patrick J., Rogers, Chris S., Toulouse, André, Xu, Xing, Zhang, Fucheng, Zhou, Zhonghe   +11 more
core   +5 more sources