Results 61 to 70 of about 276,333 (265)

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

A custom preservation solution extends the ex vivo availability of living heart valves for transplantationCentral MessagePerspective

JTCVS Open
Objectives: Although heart valve transplantation delivers living, growth-capable valves, its clinical implementation is restricted by transplant logistics and donor availability.
Elizabeth M. Cordoves, BA, Baoqi Liu, MS, Olivier Pont, BS, V. Reed LaSala, MD, Griffin Welsh Daly, BS, Keith Yeager, MS, Lucie Chicaud, BS, Richard Zhuang, MS, Senay Ustunel, PhD, Kavya Rajesh, MD, Nicole Julia, Sophia Jackman, MD, Sharon Fleischer, PhD, Emile A. Bacha, MD, Emmanuel Zorn, PhD, Giovanni Ferrari, PhD, Gordana Vunjak-Novakovic, PhD, David M. Kalfa, MD, PhD   +17 more
doaj   +1 more source

Clinical results of anterior cruciate ligament reconstruction with ligament remnant tissue preservation: A systematic review

Asia-Pacific Journal of Sports Medicine, Arthroscopy, Rehabilitation and Technology, 2016
Purpose: To clarify the effects of ACL remnant tissue preservation on the clinical outcome of ACL reconstruction. Methods: This is a systematic review.
Yoshie Tanabe, Kazunori Yasuda, Eiji Kondo, Nobuto Kitamura   +3 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Optimization of ultrastructural preservation of human brain for transmission electron microscopy after long post-mortem intervals

Acta Neuropathologica Communications, 2019
Electron microscopy (EM) provides the necessary resolution to visualize the finer structures of nervous tissue morphology, which is important to understand healthy and pathological conditions in the brain.
Mariella Sele, Stefan Wernitznig, Saška Lipovšek, Snježana Radulović, Johannes Haybaeck, Anna Maria Birkl-Toeglhofer, Christina Wodlej, Florian Kleinegger, Stephan Sygulla, Marlene Leoni, Stefan Ropele, Gerd Leitinger   +11 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Use of intraoperative ultrasound in resection of early-stage borderline ovarian tumors: A case series

Gynecologic Oncology Reports
Borderline ovarian tumors (BOTs) commonly occur in women of reproductive age. For patients desiring fertility preservation, cystectomies are recommended as healthy ovarian tissue is spared.
Karthiga Natarajan, Marilyn Boo, Samir A. Saidi   +2 more
doaj   +1 more source

Deciphering pyritization-kerogenization gradient for fish soft-tissue preservation

Scientific Reports, 2017
Soft-tissue preservation provides palaeobiological information that is otherwise lost during fossilization. In Brazil, the Early Cretaceous Santana Formation contains fish with integument, muscles, connective tissues, and eyes that are still preserved ...
Gabriel L. Osés, Setembrino Petri, Cibele G. Voltani, Gustavo M. E. M. Prado, Douglas Galante, Marcia A. Rizzutto, Isaac D. Rudnitzki, Evandro P. da Silva, Fabio Rodrigues, Elidiane C. Rangel, Paula A. Sucerquia, M. L. A. F. Pacheco   +11 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source