Results 111 to 120 of about 495,630 (303)

Fertility Preservation in Women With Malignancy: Future Endeavors

Clinical Medicine Insights: Reproductive Health, 2019
The area of fertility preservation is constantly developing. To date, the only noninvestigational and unequivocally accepted methods for fertility preservation are cryopreservation of embryos and unfertilized oocytes.
Zeev Blumenfeld
doaj   +1 more source

Flesh on the Bones: Animal Bodies in Atlantic Roundhouses [PDF]

, 2011
This volume presents the state of research across Europe to illustrate how comparable interpretative frameworks are used by archaeologists working with both prehistoric and historical ...
Madgwick, Richard, Mulville, J., Parker Pearson, M., Powell, A.   +3 more
core  

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Prevascularized spongy-like hydrogels maintain their angiogenic potential after prolonged hypothermic storage

Bioactive Materials
The chronic shortage of organs and tissues for transplantation represents a dramatic burden on healthcare systems worldwide. Tissue engineering offers a potential solution to address these shortages, but several challenges remain, with prevascularization
Sara Freitas-Ribeiro, Helena Moreira, Lucília P. da Silva, Jennifer Noro, Belém Sampaio-Marques, Paula Ludovico, Mariana Jarnalo, Ricardo Horta, Alexandra P. Marques, Rui L. Reis, Rogério P. Pirraco   +10 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

The Effect Of Intrasocket Reactive Tissue On Alveolar Ridge Preservateion

International Dental Journal
Aim or purpose: The current study aims to evaluate the efficacy of intrasocket reactive tissue for alveolar ridge preservation after extraction in severe periodontal defects. Materials and methods: A total of 61 sites were included into this study, which
Wang Yuanyuan
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Fluid preservation in brain banking: a review

Free Neuropathology
Fluid preservation is nearly universally used in brain banking to store fixed tissue specimens for future research applications. However, the effects of long-term immersion on neural circuitry and biomolecules are not well characterized.
Andrew McKenzie, Oge Nnadi, Kat D. Slagell, Emma L. Thorn, Kurt Farrell, John F. Crary   +5 more
doaj   +1 more source

Redefining stem cells through their use in musculoskeletal tissue preservation, regeneration, and cancer metastases to bone. [PDF]

Bone Rep, 2023
Drissi H, Taipaleenmäki H, Jorgensen C.
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source