Results 131 to 140 of about 489,905 (329)

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

Investigating urea is an ideal additive to the Accu-OptiClearing delipidation cocktail

Scientific Reports
The brain is a complicated tissue with high lipid content. Different tissue clearing methods have been used to study its complex structures and functions.
Michael Siu-Lun Lai, Wai Man Chick, Rachel Man Hoi Law, Raymond Chuen-Chung Chang   +3 more
doaj   +1 more source

Prevascularized spongy-like hydrogels maintain their angiogenic potential after prolonged hypothermic storage

Bioactive Materials
The chronic shortage of organs and tissues for transplantation represents a dramatic burden on healthcare systems worldwide. Tissue engineering offers a potential solution to address these shortages, but several challenges remain, with prevascularization
Sara Freitas-Ribeiro, Helena Moreira, Lucília P. da Silva, Jennifer Noro, Belém Sampaio-Marques, Paula Ludovico, Mariana Jarnalo, Ricardo Horta, Alexandra P. Marques, Rui L. Reis, Rogério P. Pirraco   +10 more
doaj   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

The Effect Of Intrasocket Reactive Tissue On Alveolar Ridge Preservateion

International Dental Journal
Aim or purpose: The current study aims to evaluate the efficacy of intrasocket reactive tissue for alveolar ridge preservation after extraction in severe periodontal defects. Materials and methods: A total of 61 sites were included into this study, which
Wang Yuanyuan
doaj   +1 more source

Bio banking of indigenous chicken germplasm by cryo-preservation of germline potent early embryonic cells and gonadal tissues

, 2020
Adnan Naim, Swati Mishra, Debasis Nayak
openalex   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Fluid preservation in brain banking: a review

Free Neuropathology
Fluid preservation is nearly universally used in brain banking to store fixed tissue specimens for future research applications. However, the effects of long-term immersion on neural circuitry and biomolecules are not well characterized.
Andrew McKenzie, Oge Nnadi, Kat D. Slagell, Emma L. Thorn, Kurt Farrell, John F. Crary   +5 more
doaj   +1 more source

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

Redefining stem cells through their use in musculoskeletal tissue preservation, regeneration, and cancer metastases to bone. [PDF]

Bone Rep, 2023
Drissi H, Taipaleenmäki H, Jorgensen C.
europepmc   +1 more source