Results 151 to 160 of about 4,666,864 (263)
The cell-adhesion molecule Echinoid promotes tissue survival and separately restricts tissue overgrowth. [PDF]
DevelopmentSpitzer DC +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source
Effect of Ice Seeding on Slow Freezing of Ovarian Tissue
Zhileng xuebaoOvarian tissue cryopreservation is an important method for female fertility preservation. Slow freezing of ovarian tissue results in poor follicular survival and low retransplantation efficiency.
Ye Na +4 more
doaj
Breast Cancer Tissue Bank Blood Samples
This BCTB subcollection consists of blood samples taken from breast cancer patients and others. It is further broken down into a number of blood components.
core
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
Study of the Effect of Ice Seeding on Slow Freezing of Ovarian Tissue
Zhileng xuebaoOvarian tissue cryopreservation is an important method of female fertility preservation, slow freezing of ovarian tissue has poor follicular survival and low retransplantation efficency.
叶娜 +4 more
doaj